MYL6_PIG
ID MYL6_PIG Reviewed; 151 AA.
AC P60662; P16475; P24572; P24573; Q12790;
DT 29-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Myosin light polypeptide 6;
DE AltName: Full=17 kDa myosin light chain;
DE Short=LC17;
DE AltName: Full=Myosin light chain 3;
DE Short=MLC-3;
DE AltName: Full=Myosin light chain alkali 3;
DE Short=Myosin light chain A3;
DE AltName: Full=Smooth muscle and nonmuscle myosin light chain alkali 6;
GN Name=MYL6;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP PROTEIN SEQUENCE (ISOFORMS NON-MUSCLE AND SMOOTH MUSCLE).
RC TISSUE=Aorta;
RX PubMed=1500421; DOI=10.1093/oxfordjournals.jbchem.a123839;
RA Hasegawa Y., Ueda Y., Watanabe M., Morita F.;
RT "Studies on amino acid sequences of two isoforms of 17-kDa essential light
RT chain of smooth muscle myosin from porcine aorta media.";
RL J. Biochem. 111:798-803(1992).
CC -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium.
CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC Interacts with SPATA6. {ECO:0000250|UniProtKB:Q60605}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=Non-muscle; Synonyms=MLC3nm, LC17A, LC17-nm;
CC IsoId=P60662-1, P16475-1;
CC Sequence=Displayed;
CC Name=Smooth muscle; Synonyms=MLC3sm, LC17B, LC17-sm;
CC IsoId=P60662-2, P24572-1;
CC Sequence=VSP_009737;
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DR PIR; JX0214; JX0214.
DR PIR; JX0215; JX0215.
DR RefSeq; NP_001157469.1; NM_001163997.1. [P60662-1]
DR RefSeq; XP_005655646.1; XM_005655589.2. [P60662-2]
DR RefSeq; XP_005655689.1; XM_005655632.2.
DR RefSeq; XP_013843762.1; XM_013988308.1.
DR AlphaFoldDB; P60662; -.
DR SMR; P60662; -.
DR STRING; 9823.ENSSSCP00000000402; -.
DR PaxDb; P60662; -.
DR PeptideAtlas; P60662; -.
DR PRIDE; P60662; -.
DR Ensembl; ENSSSCT00005013083; ENSSSCP00005007736; ENSSSCG00005007961. [P60662-1]
DR Ensembl; ENSSSCT00015090225; ENSSSCP00015036884; ENSSSCG00015066226. [P60662-1]
DR Ensembl; ENSSSCT00045031659; ENSSSCP00045021919; ENSSSCG00045018573. [P60662-1]
DR Ensembl; ENSSSCT00055014064; ENSSSCP00055011063; ENSSSCG00055006918. [P60662-2]
DR Ensembl; ENSSSCT00065073327; ENSSSCP00065031944; ENSSSCG00065053463. [P60662-1]
DR GeneID; 396807; -.
DR KEGG; ssc:396807; -.
DR CTD; 4637; -.
DR eggNOG; KOG0030; Eukaryota.
DR HOGENOM; CLU_061288_13_0_1; -.
DR InParanoid; P60662; -.
DR OrthoDB; 1470794at2759; -.
DR TreeFam; TF351553; -.
DR Reactome; R-SSC-445355; Smooth Muscle Contraction.
DR Reactome; R-SSC-5627123; RHO GTPases activate PAKs.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P60662; SS.
DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0000146; F:microfilament motor activity; IDA:HGNC-UCL.
DR GO; GO:0008307; F:structural constituent of muscle; IDA:HGNC-UCL.
DR GO; GO:0006936; P:muscle contraction; IC:HGNC-UCL.
DR GO; GO:0030049; P:muscle filament sliding; IC:HGNC-UCL.
DR CDD; cd00051; EFh; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR SMART; SM00054; EFh; 2.
DR SUPFAM; SSF47473; SSF47473; 1.
DR PROSITE; PS50222; EF_HAND_2; 2.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Direct protein sequencing;
KW Motor protein; Muscle protein; Myosin; Phosphoprotein; Reference proteome;
KW Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT CHAIN 2..151
FT /note="Myosin light polypeptide 6"
FT /id="PRO_0000198692"
FT DOMAIN 7..42
FT /note="EF-hand 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 84..119
FT /note="EF-hand 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT DOMAIN 119..151
FT /note="EF-hand 3"
FT /evidence="ECO:0000305"
FT MOD_RES 2
FT /note="N-acetylcysteine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT MOD_RES 57
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT MOD_RES 81
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P60660"
FT VAR_SEQ 143..151
FT /note="AFVRHILSG -> ELVRMVLNG (in isoform Smooth muscle)"
FT /evidence="ECO:0000303|PubMed:1500421"
FT /id="VSP_009737"
SQ SEQUENCE 151 AA; 16930 MW; A2B7B4F41179523D CRC64;
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM
NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM
TEEEVEMLVA GHEDSNGCIN YEAFVRHILS G
