ID   MYL6_RAT                Reviewed;         151 AA.
AC   Q64119;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 141.
DE   RecName: Full=Myosin light polypeptide 6;
DE   AltName: Full=17 kDa myosin light chain;
DE            Short=LC17;
DE   AltName: Full=Myosin light chain 3;
DE            Short=MLC-3;
DE   AltName: Full=Myosin light chain alkali 3;
DE            Short=Myosin light chain A3;
DE   AltName: Full=Smooth muscle and nonmuscle myosin light chain alkali 6;
GN   Name=Myl6;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Heart;
RX   PubMed=7733921; DOI=10.1006/bbrc.1995.1533;
RA   Iwai N., Shimoike H., Kinoshita M.;
RT   "Genes up-regulated in hypertrophied ventricle.";
RL   Biochem. Biophys. Res. Commun. 209:527-534(1995).
RN   [2]
RP   PROTEIN SEQUENCE OF 14-21; 80-94 AND 99-110, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Hippocampus;
RA   Lubec G., Chen W.-Q.;
RL   Submitted (APR-2007) to UniProtKB.
CC   -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium.
CC   -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains.
CC       Interacts with SPATA6. {ECO:0000250|UniProtKB:Q60605}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Smooth muscle; Synonyms=MLC3sm, LC17B, LC17-sm;
CC         IsoId=Q64119-2; Sequence=Displayed;
CC       Name=Non-muscle; Synonyms=MLC3nm, LC17A, LC17-nm;
CC         IsoId=Q64119-1; Sequence=Not described;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; S77858; AAB34126.1; -; mRNA.
DR   RefSeq; NP_001094453.1; NM_001100983.1. [Q64119-2]
DR   AlphaFoldDB; Q64119; -.
DR   SMR; Q64119; -.
DR   BioGRID; 263744; 3.
DR   IntAct; Q64119; 1.
DR   MINT; Q64119; -.
DR   STRING; 10116.ENSRNOP00000065932; -.
DR   iPTMnet; Q64119; -.
DR   PhosphoSitePlus; Q64119; -.
DR   jPOST; Q64119; -.
DR   PRIDE; Q64119; -.
DR   RGD; 1305620; Myl6.
DR   eggNOG; KOG0030; Eukaryota.
DR   InParanoid; Q64119; -.
DR   PRO; PR:Q64119; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016459; C:myosin complex; TAS:HGNC-UCL.
DR   GO; GO:0016460; C:myosin II complex; IBA:GO_Central.
DR   GO; GO:0016461; C:unconventional myosin complex; TAS:BHF-UCL.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0003774; F:cytoskeletal motor activity; TAS:HGNC-UCL.
DR   GO; GO:0000146; F:microfilament motor activity; ISS:HGNC-UCL.
DR   GO; GO:0008307; F:structural constituent of muscle; ISS:HGNC-UCL.
DR   GO; GO:0006936; P:muscle contraction; TAS:HGNC-UCL.
DR   GO; GO:0030049; P:muscle filament sliding; TAS:HGNC-UCL.
DR   GO; GO:0007519; P:skeletal muscle tissue development; TAS:HGNC-UCL.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   SMART; SM00054; EFh; 3.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50222; EF_HAND_2; 3.
PE   1: Evidence at protein level;
KW   Acetylation; Alternative splicing; Direct protein sequencing;
KW   Motor protein; Muscle protein; Myosin; Phosphoprotein; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P60660"
FT   CHAIN           2..151
FT                   /note="Myosin light polypeptide 6"
FT                   /id="PRO_0000198693"
FT   DOMAIN          7..42
FT                   /note="EF-hand 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          84..119
FT                   /note="EF-hand 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   DOMAIN          119..151
FT                   /note="EF-hand 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00448"
FT   MOD_RES         2
FT                   /note="N-acetylcysteine"
FT                   /evidence="ECO:0000250|UniProtKB:P60660"
FT   MOD_RES         57
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P60660"
FT   MOD_RES         81
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:P60660"
SQ   SEQUENCE   151 AA;  16975 MW;  25B244E6860947D3 CRC64;
     MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK VLGNPKSDEM
     NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG NGTVMGAEIR HVLVTLGEKM
     TEEEVEMLVA GHEDSNGCIN YEELLRMVLN G