ID   MYLK_MELGA              Reviewed;         154 AA.
AC   P56276;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Telokin;
OS   Meleagris gallopavo (Wild turkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Meleagridinae; Meleagris.
OX   NCBI_TaxID=9103;
RN   [1]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS).
RC   TISSUE=Gizzard;
RX   PubMed=1404391; DOI=10.1016/0022-2836(92)90226-a;
RA   Holden H.M., Ito M., Hartshorne D.J., Rayment I.;
RT   "X-ray structure determination of telokin, the C-terminal domain of myosin
RT   light chain kinase, at 2.8-A resolution.";
RL   J. Mol. Biol. 227:840-851(1992).
CC   -!- FUNCTION: Corresponds to the C-terminus of smooth muscle myosin light
CC       chain kinase.
CC   -!- SUBUNIT: Binds calmodulin. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC       protein kinase family. {ECO:0000305}.
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DR   PDB; 1FHG; X-ray; 2.00 A; A=1-154.
DR   PDB; 1TLK; X-ray; 2.80 A; A=1-154.
DR   PDBsum; 1FHG; -.
DR   PDBsum; 1TLK; -.
DR   AlphaFoldDB; P56276; -.
DR   SMR; P56276; -.
DR   EvolutionaryTrace; P56276; -.
DR   Proteomes; UP000001645; Unplaced.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   Pfam; PF07679; I-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00408; IGc2; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Calmodulin-binding; Immunoglobulin domain;
KW   Reference proteome.
FT   CHAIN           1..154
FT                   /note="Telokin"
FT                   /id="PRO_0000086407"
FT   DOMAIN          42..133
FT                   /note="Ig-like C2-type"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          134..154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..154
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   STRAND          40..46
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          51..54
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          59..69
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          72..77
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          85..92
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          97..104
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   HELIX           107..109
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          111..119
FT                   /evidence="ECO:0007829|PDB:1FHG"
FT   STRAND          122..133
FT                   /evidence="ECO:0007829|PDB:1FHG"
SQ   SEQUENCE   154 AA;  16944 MW;  66F5996028B8345B CRC64;
     ISGMSGRKAS GSSPTSPINA NKVENEDAFL EEVAEEKPHV KPYFTKTILD MDVVEGSAAR
     FDCKVEGYPD PEVMWFKDDN PVKESRHFQI DYDEEGNCSL TISEVCGDDD AKYTCKAVNS
     LGEATCTAEL LVETMGKEGE GEGEGEEDEE EEEE