MYNN_DANRE
ID MYNN_DANRE Reviewed; 810 AA.
AC Q7ZVR6;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Myoneurin;
GN Name=mynn; ORFNames=zgc:55724;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC045441; AAH45441.1; -; mRNA.
DR RefSeq; NP_956062.1; NM_199768.1.
DR AlphaFoldDB; Q7ZVR6; -.
DR SMR; Q7ZVR6; -.
DR STRING; 7955.ENSDARP00000016471; -.
DR PaxDb; Q7ZVR6; -.
DR GeneID; 327167; -.
DR KEGG; dre:327167; -.
DR CTD; 55892; -.
DR ZFIN; ZDB-GENE-030131-5378; mynn.
DR eggNOG; KOG1721; Eukaryota.
DR InParanoid; Q7ZVR6; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q7ZVR6; -.
DR PRO; PR:Q7ZVR6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR017956; AT_hook_DNA-bd_motif.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR000637; HMGI/Y_DNA-bd_CS.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR PRINTS; PR00929; ATHOOK.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00354; HMGI_Y; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..810
FT /note="Myoneurin"
FT /id="PRO_0000248220"
FT DOMAIN 24..91
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT DNA_BIND 254..266
FT /note="A.T hook 1"
FT DNA_BIND 318..330
FT /note="A.T hook 2"
FT DNA_BIND 361..373
FT /note="A.T hook 3"
FT ZN_FING 472..494
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 500..522
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 528..551
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 557..579
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 585..607
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 613..635
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 641..663
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 122..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 428..432
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 192..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..328
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..348
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..373
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..408
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..458
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 810 AA; 91120 MW; 26FC0A3A97CCC965 CRC64;
MPHITHSEFL LEQLKRQRER SFLCDCTVSI GQAQYRAHHN VLAAFSEYFS TQSVDAGRED
PTITLDPESV SSAIFEKLLT YIYTGDLNMD REEIESVQKA ASYLGMPEVV ARCTLSQDNI
KNVGSPMRQA EYEDPRSPLS PDDYEPLEPI SEVEERELLR EDRAGDDLVS MDEAQSSSEQ
TPQRVGKRGR KPKTRLYEDE FEVETISAQR GRGRGRGRPR GRPRVRPLSS DSTDQSPAHQ
AMSPNGSSTS RGSGRPRGRP RVRPLSTANE DPRNVEDDPA ANKDQEVEKG NEEQKKETGE
KDDGKNDTDN PEEVTAFKRG RGRPRIKPVS TEDQTTNSEN VTTNAEDGSE PAKTKDSEGT
GRKRGRPRSK PVSSEDPESV ISVEISGEEA GEETSQDAEK HTEEGTEDSE SNPGNSVRIS
KRKRILSRKL KESQAGDEEE EEEEEMDDEF ENDNEDWAGE EEVKPVQDKH RPICNICGNL
FSEMSSLRRH MRIHKGLKPY QCTLCTRSFR QGNQLKTHMR IHTGEKPFTC TSCDSRFAQK
CQLVYHCRMH HGEEKPYKCE FCGAAFATSS NLKIHIRKHS GEKPYECGEC GKRFTQASTL
MYHKRRHTGE KPYICDTCGM AFAVSSSLIA HNRKHTGVTP YICLDCGKPC LTAGELRKHM
DVHNDIYSLK KHSILKHNVV PELETTQTSK TDPTQCPLNI PIDHQGLIAR VRSALVDSQD
HEIQMEPPLP ILPPETSLTI QQSAEPQMII QHADGSEPSM IFQHAEASEA PMLIQHGEPG
EQVSYVVEQY EIPATAEMEH TQIVIVQTID
