MYNN_MOUSE
ID MYNN_MOUSE Reviewed; 610 AA.
AC Q99MD8; Q6P1G7; Q8BT55; Q922I4; Q9CSA0; Q9CXJ8;
DT 05-SEP-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 2.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Myoneurin;
GN Name=Mynn;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=10873615; DOI=10.1006/bbrc.2000.2862;
RA Alliel P.M., Seddiqi N., Goudou D., Cifuentes-Diaz C., Romero N.,
RA Velasco E., Rieger F., Perin J.-P.;
RT "Myoneurin, a novel member of the BTB/POZ-zinc finger family highly
RT expressed in human muscle.";
RL Biochem. Biophys. Res. Commun. 273:385-391(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=14694499; DOI=10.1002/mus.10526;
RA Cifuentes-Diaz C., Bitoun M., Goudou D., Seddiqi N., Romero N., Rieger F.,
RA Perin J.-P., Alliel P.M.;
RT "Neuromuscular expression of the BTB/POZ and zinc finger protein
RT myoneurin.";
RL Muscle Nerve 29:59-65(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:14694499}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q99MD8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99MD8-2; Sequence=VSP_020220;
CC Name=3;
CC IsoId=Q99MD8-3; Sequence=VSP_020218, VSP_020219;
CC -!- TISSUE SPECIFICITY: Mainly expressed in the neuromuscular system.
CC Located in and around synaptic myonuclei in adult muscle. Expression is
CC dysregulated after nerve injury. Also found in the cerebellum, testis,
CC heart, brain and liver. {ECO:0000269|PubMed:10873615,
CC ECO:0000269|PubMed:14694499}.
CC -!- DEVELOPMENTAL STAGE: Expression is developmentally regulated in muscle
CC and is associated with neuromuscular junctions during the late
CC embryonic period. {ECO:0000269|PubMed:14694499}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AF349561; AAK18605.1; -; mRNA.
DR EMBL; AK014315; BAB29266.1; -; mRNA.
DR EMBL; AK019238; BAC25584.2; -; mRNA.
DR EMBL; AK013445; BAB28858.1; -; mRNA.
DR EMBL; AK136107; BAE22823.1; -; mRNA.
DR EMBL; BC007477; AAH07477.1; -; mRNA.
DR EMBL; BC065084; AAH65084.1; -; mRNA.
DR CCDS; CCDS17284.1; -. [Q99MD8-1]
DR CCDS; CCDS79891.1; -. [Q99MD8-2]
DR RefSeq; NP_001276550.1; NM_001289621.1. [Q99MD8-2]
DR RefSeq; NP_001276551.1; NM_001289622.1.
DR RefSeq; NP_001276552.1; NM_001289623.1.
DR RefSeq; NP_085034.2; NM_030557.3. [Q99MD8-1]
DR AlphaFoldDB; Q99MD8; -.
DR SMR; Q99MD8; -.
DR BioGRID; 219802; 24.
DR IntAct; Q99MD8; 1.
DR STRING; 10090.ENSMUSP00000041034; -.
DR iPTMnet; Q99MD8; -.
DR PhosphoSitePlus; Q99MD8; -.
DR EPD; Q99MD8; -.
DR MaxQB; Q99MD8; -.
DR PaxDb; Q99MD8; -.
DR PeptideAtlas; Q99MD8; -.
DR PRIDE; Q99MD8; -.
DR ProteomicsDB; 293599; -. [Q99MD8-1]
DR ProteomicsDB; 293600; -. [Q99MD8-2]
DR Antibodypedia; 18640; 254 antibodies from 26 providers.
DR DNASU; 80732; -.
DR Ensembl; ENSMUST00000047502; ENSMUSP00000041034; ENSMUSG00000037730. [Q99MD8-2]
DR Ensembl; ENSMUST00000192715; ENSMUSP00000141951; ENSMUSG00000037730. [Q99MD8-1]
DR Ensembl; ENSMUST00000195396; ENSMUSP00000141623; ENSMUSG00000037730. [Q99MD8-3]
DR Ensembl; ENSMUST00000195751; ENSMUSP00000141450; ENSMUSG00000037730. [Q99MD8-3]
DR GeneID; 80732; -.
DR KEGG; mmu:80732; -.
DR UCSC; uc008oux.2; mouse. [Q99MD8-1]
DR UCSC; uc008ouz.2; mouse. [Q99MD8-2]
DR CTD; 55892; -.
DR MGI; MGI:1931415; Mynn.
DR VEuPathDB; HostDB:ENSMUSG00000037730; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161266; -.
DR HOGENOM; CLU_022540_1_0_1; -.
DR InParanoid; Q99MD8; -.
DR OMA; TNCDAKF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q99MD8; -.
DR TreeFam; TF330787; -.
DR BioGRID-ORCS; 80732; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Mynn; mouse.
DR PRO; PR:Q99MD8; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q99MD8; protein.
DR Bgee; ENSMUSG00000037730; Expressed in metanephric loop of Henle and 249 other tissues.
DR Genevisible; Q99MD8; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IEP:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF54695; SSF54695; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..610
FT /note="Myoneurin"
FT /id="PRO_0000248218"
FT DOMAIN 24..89
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT ZN_FING 302..324
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..381
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 387..409
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 415..437
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 443..465
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 471..493
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 499..522
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 156..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 174..190
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 257..262
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 157..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..188
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..541
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 46..60
FT /note="SEYFGAIYRSTSENN -> IGMLKKSIRLLTISK (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020218"
FT VAR_SEQ 61..610
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_020219"
FT VAR_SEQ 468..495
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_020220"
FT CONFLICT 127
FT /note="T -> A (in Ref. 2; BAB28858)"
FT /evidence="ECO:0000305"
FT CONFLICT 130
FT /note="S -> I (in Ref. 2; BAC25584)"
FT /evidence="ECO:0000305"
FT CONFLICT 168
FT /note="K -> Q (in Ref. 2; BAB29266)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="A -> G (in Ref. 2; BAB29266)"
FT /evidence="ECO:0000305"
FT CONFLICT 440
FT /note="E -> G (in Ref. 1; AAK18605)"
FT /evidence="ECO:0000305"
FT CONFLICT 512
FT /note="K -> E (in Ref. 2; BAC25584)"
FT /evidence="ECO:0000305"
FT CONFLICT 518
FT /note="K -> E (in Ref. 2; BAC25584)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 610 AA; 68593 MW; 0FB8DC19C0501935 CRC64;
MQYSHHCEHL LERLNKQREA GFLCDCTVVI GEFQFKAHRN VLASFSEYFG AIYRSTSENN
VFLDQSQVKA DGFQKLLEFI YTGTLNLDSW NVKEIHQAAD YLKVEEVVTK CKIKMEDFAF
IASPSSTEIS SITGNIELNQ QACLLTLRDY NNREKSEVST DSVQANPKPR ALTKKSSQSK
KKKKAFSSQK PGQSKAVQYP SDVLESASVE LFLETSKLSS PVVEQIIQGN DSSELELTSV
VENTFPTQDI VQTVTVKRKR RKSQSHCALK EHSMSNIASV KSPYELENAG EELDARFSKA
KPMCNTCGKV FSEASSLRRH MRIHKGVKPY VCHLCGKAFT QCNQLKTHVR THTGERPYKC
ELCDKGFAQK CQLVFHSRMH HGEEKPYKCD VCNLQFATSS NLKIHARKHS GEKPYVCDRC
GQRFAQASTL TYHVRRHTGE KPYVCDTCGK AFAVSSSLIT HSRKHTGEKP YICGICGKSF
ISSGELNKHF RSHTGERPFI CELCGNSYTD IKNLKKHKTK VHSGTDKNPD CSVDDHAVSE
QDSVQRSPLS ETLDVKPSDM TLPLALPLGT EDHQMLLPVT DSQSPASDTL LRSTVNGYSE
PQLIFLQQLY
