MYO13_ARATH
ID MYO13_ARATH Reviewed; 1493 AA.
AC F4IUG9; Q9SK73;
DT 26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 03-AUG-2022, entry version 70.
DE RecName: Full=Myosin-13;
DE AltName: Full=Myosin XI G;
DE Short=AtXIG;
GN Name=XI-G; Synonyms=XIG; OrderedLocusNames=At2g20290; ORFNames=F11A3.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=10984423; DOI=10.1242/jcs.113.19.3353;
RA Hodge T., Cope M.J.;
RT "A myosin family tree.";
RL J. Cell Sci. 113:3353-3354(2000).
RN [4]
RP GENE FAMILY.
RX PubMed=11516337; DOI=10.1186/gb-2001-2-7-research0024;
RA Reddy A.S., Day I.S.;
RT "Analysis of the myosins encoded in the recently completed Arabidopsis
RT thaliana genome sequence.";
RL Genome Biol. 2:RESEARCH0024.1-RESEARCH0024.17(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=21233331; DOI=10.1104/pp.110.170720;
RA Peremyslov V.V., Mockler T.C., Filichkin S.A., Fox S.E., Jaiswal P.,
RA Makarova K.S., Koonin E.V., Dolja V.V.;
RT "Expression, splicing, and evolution of the myosin gene family in plants.";
RL Plant Physiol. 155:1191-1204(2011).
CC -!- FUNCTION: Myosin heavy chain that is required for the cell cycle-
CC regulated transport of various organelles and proteins for their
CC segregation. Functions by binding with its tail domain to receptor
CC proteins on organelles and exerting force with its N-terminal motor
CC domain against actin filaments, thereby transporting its cargo along
CC polarized actin cables (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- DOMAIN: IQ domain mediates interaction with calmodulin. {ECO:0000250}.
CC -!- DOMAIN: The tail domain is a globular cargo-binding domain.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. Plant myosin class XI subfamily.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD21759.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC006569; AAD21759.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06990.1; -; Genomic_DNA.
DR PIR; D84587; D84587.
DR RefSeq; NP_179619.2; NM_127588.3.
DR AlphaFoldDB; F4IUG9; -.
DR SMR; F4IUG9; -.
DR STRING; 3702.AT2G20290.1; -.
DR iPTMnet; F4IUG9; -.
DR PaxDb; F4IUG9; -.
DR PRIDE; F4IUG9; -.
DR ProteomicsDB; 251336; -.
DR EnsemblPlants; AT2G20290.1; AT2G20290.1; AT2G20290.
DR GeneID; 816548; -.
DR Gramene; AT2G20290.1; AT2G20290.1; AT2G20290.
DR KEGG; ath:AT2G20290; -.
DR Araport; AT2G20290; -.
DR TAIR; locus:2039007; AT2G20290.
DR eggNOG; KOG0160; Eukaryota.
DR HOGENOM; CLU_000192_3_1_1; -.
DR InParanoid; F4IUG9; -.
DR OrthoDB; 311886at2759; -.
DR PRO; PR:F4IUG9; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; F4IUG9; baseline and differential.
DR Genevisible; F4IUG9; AT.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISS:TAIR.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030048; P:actin filament-based movement; TAS:TAIR.
DR GO; GO:0048767; P:root hair elongation; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd15475; MyosinXI_CBD; 1.
DR CDD; cd01384; MYSc_Myo11; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR037975; MyosinXI_CBD.
DR InterPro; IPR036018; MYSc_Myo11.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 5.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; SSF52540; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 4.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Motor protein;
KW Myosin; Nucleotide-binding; Reference proteome; Repeat.
FT CHAIN 1..1493
FT /note="Myosin-13"
FT /id="PRO_0000422868"
FT DOMAIN 18..67
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01190"
FT DOMAIN 72..741
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 744..773
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 767..796
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 792..821
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 813..842
FT /note="IQ 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 836..865
FT /note="IQ 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 859..888
FT /note="IQ 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1161..1444
FT /note="Dilute"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00503"
FT REGION 504..538
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 540..563
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 598..622
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 622..644
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 1085..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 889..1057
FT /evidence="ECO:0000255"
FT COMPBIAS 1085..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 166..173
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
FT BINDING 219..227
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1493 AA; 169073 MW; 152B08980A2953A2 CRC64;
MVFKVFSFVA FMACSTVKVG SIVWVQDPEE AWIDGEVVEV NGEDIKVQCT SGKTVVAKGS
NTYPKDMEVP PSGVDDMTTL AYLHEPGVLQ NLKSRYYIDE IYTYTGNILI AVNPFKQLPN
LYNDHMMAQY KGAALGELSP HPFAVADAAY RQMINEGISQ SILVSGESGA GKTETAKMLM
KYLAKMGGRA VSDRRTVEDQ VLESNPVLEA FGNAKTVKNN NSSRFGKFVE IQFDQRGRIS
GAAIRTYLLE RSRVCQVSDP ERNYHCFYML CAAPPEDKRK LKLNDPTEFR YLNQSHCIKL
DGVDDSKEYT KTREAMGIVG INLEEQEAIF RVVAAILHLG NIEFAIGEEP DSSVPTDESK
KYLKIAAELF MCDEQALEDS LCKRIMVTPE ETISRCLDPN SAALSRDALA KFVYSRLFDW
IVNKINNSIG QDPDSKDMIG VLDIYGFESF KTNSFEQFCI NLTNEKLQQH FTQHVLKMEQ
EEYTKEEIEW SQITFPDNRY VLELIEKKRG GIIALLDEAC MFPRSTHKTF SQKLYETLKD
NKYFSKPKLS RTDFTICHYA GDVTYQTEQF LEKNKDYVVA EHQALLGASR CTFIAGLFPP
LVEDANKQSK FSSIASQFKQ QLASLIEGLN TTEPHYIRCV KPNNLLKPSI FENQNSLQQL
RCGGVMETIR VCRAGYPTRK HFDEFLDRFG ILDSATLDKS SDEKAACKKL LETVGLNGFQ
IGKTKVFLKA GQMAELDDRR TEVLGRAACI IQWKFRSYLT RQSFIMLRNA AINIQAVYRG
QVARYRFENL RREAAALKIQ RALRIHLDRK RSYIEAVVTV QSGLRGMAAR VVLRRKTKAT
TVIQSHCRRL RAELHYKKLK KAAITTQSAW RARLARKELR KLKTDARDTV VLQAAKSMLA
EKVEELTWRL DLEKRMRVDM EVSKAQENAK LQLALEEIQL QFEETKVSLL KEVEAAKKTA
AIVPVVKEVP VVDTVLMEKL TSENEKLKSL VTSLELKIDE TEKKFEETKK ISEERLKKAL
DAENKIDNLK TAMHNLEEKL KEVKLENNFL KESVLTTPVK TASGRFLSTP LKNLQNGLFT
SEESQLSGAE FTTPPRIQES GSDTKSRGSH IDPQHEDVDA LINSVTKNVG FSQGKPVAAF
TIYKCLLHWK SFEAERTNVF DRLVQMIGSA IKDEDNDANL AYWLSNTSTL LFMLQQSLKS
GGTGATPLRQ SPSLVRWMTK GFRSPAAEAI RPVDAKDPAL HFKQQLEAYV EKILGIIWDN
LKKELNTVLA LCIQAPKTFK GNALISITTA NYWQDIIEGL DALLSTLKES FVPPVLIQKI
FSQAFSLINV QVCNSLVTRP DNCSFINGEY LKSGLEKLEK WCCETKEEYA GSSWDELKHT
RQAVGFLLIH KKYNISYDEI ANDLCPNLQI QQHFKLCTLY KDEIYNTKSV SQDVIASMTG
VMTDSSDFLL KEDSSNIISL SIDDLCSSMQ DKDFAQVKPA EELLENPSFI FLH
