MYO16_HUMAN
ID MYO16_HUMAN Reviewed; 1858 AA.
AC Q9Y6X6; A6H8Y0; A8MTX3; Q5VYX4; Q5VYX5; Q5VYX6; Q6ZS13; Q8N3C2; Q8N948;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 3.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Unconventional myosin-XVI;
DE AltName: Full=Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3;
DE AltName: Full=Unconventional myosin-16;
GN Name=MYO16 {ECO:0000312|HGNC:HGNC:29822};
GN Synonyms=KIAA0865 {ECO:0000312|EMBL:BAA74888.2},
GN MYO16B {ECO:0000312|HGNC:HGNC:29822}, NYAP3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAA74888.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-831.
RC TISSUE=Brain {ECO:0000312|EMBL:BAA74888.2};
RX PubMed=10048485; DOI=10.1093/dnares/5.6.355;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 5:355-364(1998).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAC04608.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 1-995 (ISOFORMS 1/3), AND VARIANTS THR-385 AND
RP ALA-831.
RC TISSUE=Brain {ECO:0000312|EMBL:BAC04608.1};
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3] {ECO:0000305, ECO:0000312|EMBL:CAD39107.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-831.
RC TISSUE=Brain;
RA Yamakawa H., Kikuno R.F., Nagase T., Ohara O.;
RT "Multiplex amplification and cloning of 5'-ends of cDNA by ligase-free
RT recombination: preparation of full-length cDNA clones encoding motor
RT proteins.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AL136132}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ALA-831.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-935 (ISOFORMS 1/2/3), AND
RP VARIANT ALA-831.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP INTERACTION WITH KIRREL3.
RX PubMed=25902260; DOI=10.1371/journal.pone.0123106;
RA Liu Y.F., Sowell S.M., Luo Y., Chaubey A., Cameron R.S., Kim H.G.,
RA Srivastava A.K.;
RT "Autism and intellectual disability-associated KIRREL3 interacts with
RT neuronal proteins MAP1B and MYO16 with potential roles in
RT neurodevelopment.";
RL PLoS ONE 10:E0123106-E0123106(2015).
RN [8]
RP VARIANT HIS-1168.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity.
CC Unconventional myosins serve in intracellular movements. Their highly
CC divergent tails are presumed to bind to membranous compartments, which
CC would be moved relative to actin filaments. May be involved in
CC targeting of the catalytic subunit of protein phosphatase 1 during
CC brain development. Activates PI3K and concomitantly recruits the WAVE1
CC complex to the close vicinity of PI3K and regulates neuronal
CC morphogenesis (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Binds PPP1CA and/or PPP1CC. Binds F-actin in an ATP-sensitive
CC manner. Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with
CC components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction
CC mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By
CC similarity). Interacts with KIRREL3 (PubMed:25902260).
CC {ECO:0000250|UniProtKB:Q5DU14, ECO:0000250|UniProtKB:Q9ERC1,
CC ECO:0000269|PubMed:25902260}.
CC -!- INTERACTION:
CC Q9Y6X6; Q8IZU9: KIRREL3; NbExp=4; IntAct=EBI-310686, EBI-16427312;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9ERC1}.
CC Note=Found in puncta in soma and processes of astrocytes and
CC dissociated cerebellar cells with the morphology of migrating granule
CC cells. {ECO:0000250|UniProtKB:Q9ERC1}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1 {ECO:0000269|PubMed:10048485};
CC IsoId=Q9Y6X6-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:14702039};
CC IsoId=Q9Y6X6-2; Sequence=VSP_052451;
CC Name=3 {ECO:0000269|PubMed:15057823};
CC IsoId=Q9Y6X6-3; Sequence=VSP_052449, VSP_052450;
CC Name=4 {ECO:0000269|PubMed:15057823};
CC IsoId=Q9Y6X6-4; Sequence=VSP_052447, VSP_052448, VSP_052449,
CC VSP_052450;
CC -!- PTM: Phosphorylated on tyrosine residues by FYN upon stimulation with
CC CNTN5. {ECO:0000250}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the TRAFAC class
CC myosin-kinesin ATPase superfamily. Myosin family. {ECO:0000305}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the NYAP family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA74888.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC04608.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87143.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB020672; BAA74888.2; ALT_INIT; mRNA.
DR EMBL; AK095691; BAC04608.1; ALT_INIT; mRNA.
DR EMBL; AB290159; BAG06713.1; -; mRNA.
DR EMBL; AL136132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL157771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL161431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL353143; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL390918; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK127806; BAC87143.1; ALT_INIT; mRNA.
DR EMBL; BC146791; AAI46792.1; -; mRNA.
DR EMBL; AL834447; CAD39107.2; -; mRNA.
DR CCDS; CCDS32008.1; -. [Q9Y6X6-1]
DR RefSeq; NP_055826.1; NM_015011.1. [Q9Y6X6-1]
DR RefSeq; XP_011519364.1; XM_011521062.1. [Q9Y6X6-1]
DR AlphaFoldDB; Q9Y6X6; -.
DR SMR; Q9Y6X6; -.
DR BioGRID; 116666; 11.
DR ELM; Q9Y6X6; -.
DR IntAct; Q9Y6X6; 10.
DR MINT; Q9Y6X6; -.
DR STRING; 9606.ENSP00000401633; -.
DR iPTMnet; Q9Y6X6; -.
DR PhosphoSitePlus; Q9Y6X6; -.
DR BioMuta; MYO16; -.
DR DMDM; 152112422; -.
DR EPD; Q9Y6X6; -.
DR MassIVE; Q9Y6X6; -.
DR MaxQB; Q9Y6X6; -.
DR PaxDb; Q9Y6X6; -.
DR PeptideAtlas; Q9Y6X6; -.
DR PRIDE; Q9Y6X6; -.
DR ProteomicsDB; 86817; -. [Q9Y6X6-1]
DR ProteomicsDB; 86818; -. [Q9Y6X6-2]
DR ProteomicsDB; 86819; -. [Q9Y6X6-3]
DR ProteomicsDB; 86820; -. [Q9Y6X6-4]
DR Antibodypedia; 42542; 79 antibodies from 20 providers.
DR DNASU; 23026; -.
DR Ensembl; ENST00000251041.10; ENSP00000251041.5; ENSG00000041515.16. [Q9Y6X6-3]
DR Ensembl; ENST00000356711.7; ENSP00000349145.2; ENSG00000041515.16. [Q9Y6X6-1]
DR GeneID; 23026; -.
DR KEGG; hsa:23026; -.
DR UCSC; uc001vqt.1; human. [Q9Y6X6-1]
DR CTD; 23026; -.
DR DisGeNET; 23026; -.
DR GeneCards; MYO16; -.
DR HGNC; HGNC:29822; MYO16.
DR HPA; ENSG00000041515; Tissue enhanced (brain).
DR MIM; 615479; gene.
DR neXtProt; NX_Q9Y6X6; -.
DR OpenTargets; ENSG00000041515; -.
DR PharmGKB; PA162396437; -.
DR VEuPathDB; HostDB:ENSG00000041515; -.
DR eggNOG; KOG0161; Eukaryota.
DR eggNOG; KOG0515; Eukaryota.
DR GeneTree; ENSGT00940000158920; -.
DR HOGENOM; CLU_013794_0_0_1; -.
DR InParanoid; Q9Y6X6; -.
DR PhylomeDB; Q9Y6X6; -.
DR TreeFam; TF332267; -.
DR PathwayCommons; Q9Y6X6; -.
DR SignaLink; Q9Y6X6; -.
DR BioGRID-ORCS; 23026; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; MYO16; human.
DR GenomeRNAi; 23026; -.
DR Pharos; Q9Y6X6; Tbio.
DR PRO; PR:Q9Y6X6; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q9Y6X6; protein.
DR Bgee; ENSG00000041515; Expressed in cortical plate and 98 other tissues.
DR ExpressionAtlas; Q9Y6X6; baseline and differential.
DR Genevisible; Q9Y6X6; HS.
DR GO; GO:0005737; C:cytoplasm; ISS:HGNC-UCL.
DR GO; GO:0016459; C:myosin complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HGNC-UCL.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:HGNC-UCL.
DR GO; GO:0005886; C:plasma membrane; ISS:HGNC-UCL.
DR GO; GO:0051015; F:actin filament binding; ISS:HGNC-UCL.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:InterPro.
DR GO; GO:0019903; F:protein phosphatase binding; IBA:GO_Central.
DR GO; GO:0021549; P:cerebellum development; ISS:HGNC-UCL.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:HGNC-UCL.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; ISS:HGNC.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0014065; P:phosphatidylinositol 3-kinase signaling; IBA:GO_Central.
DR CDD; cd14878; MYSc_Myo16; 1.
DR Gene3D; 1.25.40.20; -; 2.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036042; MYSc_Myo16.
DR InterPro; IPR039482; NYAP_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF15439; NYAP_N; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF48403; SSF48403; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 1: Evidence at protein level;
KW Actin-binding; Alternative splicing; ANK repeat; ATP-binding; Cytoplasm;
KW Motor protein; Myosin; Nucleotide-binding; Phosphoprotein;
KW Reference proteome; Repeat.
FT CHAIN 1..1858
FT /note="Unconventional myosin-XVI"
FT /id="PRO_0000289136"
FT REPEAT 59..88
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 92..121
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 125..154
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 158..189
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 191..217
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REPEAT 221..250
FT /note="ANK 6"
FT /evidence="ECO:0000255"
FT REPEAT 254..283
FT /note="ANK 7"
FT /evidence="ECO:0000255"
FT DOMAIN 401..1145
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 1147..1176
FT /note="IQ"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 373..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1111..1377
FT /note="Involved in CYFIP1- and NCKAP1-binding"
FT /evidence="ECO:0000250"
FT REGION 1219..1250
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1307
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1326..1409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1448..1674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1821..1844
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..390
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1219..1248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1329..1346
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1474..1498
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1548
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1568..1596
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1702..1731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1763..1778
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 497..504
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT VAR_SEQ 1..192
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15057823"
FT /id="VSP_052447"
FT VAR_SEQ 206..225
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15057823"
FT /id="VSP_052448"
FT VAR_SEQ 936..940
FT /note="TSENV -> RGRCF (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15057823"
FT /id="VSP_052449"
FT VAR_SEQ 941..1858
FT /note="Missing (in isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15057823"
FT /id="VSP_052450"
FT VAR_SEQ 1091..1858
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_052451"
FT VARIANT 181
FT /note="D -> E (in dbSNP:rs911973)"
FT /id="VAR_050214"
FT VARIANT 339
FT /note="V -> I (in dbSNP:rs405397)"
FT /id="VAR_050215"
FT VARIANT 385
FT /note="M -> T (in dbSNP:rs16973313)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_032584"
FT VARIANT 831
FT /note="P -> A (in dbSNP:rs3825491)"
FT /evidence="ECO:0000269|PubMed:10048485,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.3"
FT /id="VAR_032585"
FT VARIANT 1168
FT /note="L -> H (found in a renal cell carcinoma sample;
FT somatic mutation)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064737"
FT VARIANT 1171
FT /note="I -> M (in dbSNP:rs157024)"
FT /id="VAR_050216"
FT CONFLICT 555
FT /note="K -> E (in Ref. 6; CAD39107)"
FT /evidence="ECO:0000305"
FT CONFLICT 953
FT /note="T -> A (in Ref. 2; BAC87143)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1858 AA; 206129 MW; B2D821DD53BD109E CRC64;
MEIDQCLLES LPLGQRQRLV KRMRCEQIKA YYEREKAFQK QEGFLKRLKH AKNPKVHFNL
TDMLQDAIIH HNDKEVLRLL KEGADPHTLV SSGGSLLHLC ARYDNAFIAE ILIDRGVNVN
HQDEDFWTPM HIACACDNPD IVLLLVLAGA NVLLQDVNGN IPLDYAVEGT ESSSILLTYL
DENGVDLTSL RQMKLQRPMS MLTDVKHFLS SGGNVNEKND EGVTLLHMAC ASGYKEVVSL
ILEHGGDLNI VDDQYWTPLH LAAKYGQTNL VKLLLMHQAN PHLVNCNEEK ASDIAASEFI
EEMLLKAEIA WEEKMKEPLS ASTLAQEEPY EEIIHDLPVL SSKLSPLVLP IAKQDSLLEK
DIMFKDATKG LCKQQSQDSI PENPMMSGST KPEQVKLMPP APNDDLATLS ELNDGSLLYE
IQKRFGNNQI YTFIGDILLL VNPYKELPIY SSMVSQLYFS SSGKLCSSLP PHLFSCVERA
FHQLFREQRP QCFILSGERG SGKSEASKQI IRHLTCRAGA SRATLDSRFK HVVCILEAFG
HAKTTLNDLS SCFIKYFELQ FCERKQQLTG ARIYTYLLEK SRLVSQPLGQ SNFLIFYLLM
DGLSAEEKYG LHLNNLCAHR YLNQTIQDDA STGERSLNRE KLAVLKRALN VVGFSSLEVE
NLFVILAAIL HLGDIRFTAL NEGNSAFVSD LQLLEQVAGM LQVSTDELAS ALTTDIQYFK
GDMIIRRHTI QIAEFFRDLL AKSLYSRLFS FLVNTMNSCL HSQDEQKSMQ TLDIGILDIF
GFEEFQKNEF EQLCVNMTNE KMHHYINEVL FLHEQVECVQ EGVTMETAYS PGNQNGVLDF
FFQKPSGFLT LLDEESQMIW SVESNFPKKL QSLLESSNTN AVYSPMKDGN GNVALKDHGT
AFTIMHYAGR VMYDVVGAIE KNKDSLSQNL LFVMKTSENV VINHLFQSKL SQTGSLVSAY
PSFKFRGHKS ALLSKKMTAS SIIGENKNYL ELSKLLKKKG TSTFLQRLER GDPVTIASQL
RKSLMDIIGK LQKCTPHFIH CIRPNNSKLP DTFDNFYVSA QLQYIGVLEM VKIFRYGYPV
RLSFSDFLSR YKPLADTFLR EKKEQSAAER CRLVLQQCKL QGWQMGVRKV FLKYWHADQL
NDLCLQLQRK IITCQKVIRG FLARQHLLQR ISIRQQEVTS INSFLQNTED MGLKTYDALV
IQNASDIARE NDRLRSEMNA PYHKEKLEVR NMQEEGSKRT DDKSGPRHFH PSSMSVCAAV
DGLGQCLVGP SIWSPSLHSV FSMDDSSSLP SPRKQPPPKP KRDPNTRLSA SYEAVSACLS
AAREAANEAL ARPRPHSDDY STMKKIPPRK PKRSPNTKLS GSYEEISGSR PGDARPAGAP
GAAARVLTPG TPQCALPPAA PPGDEDDSEP VYIEMLGHAA RPDSPDPGES VYEEMKCCLP
DDGGPGAGSF LLHGASPPLL HRAPEDEAAG PPGDACDIPP PFPNLLPHRP PLLVFPPTPV
TCSPASDESP LTPLEVKKLP VLETNLKYPV QPEGSSPLSP QYSKSQKGDG DRPASPGLAL
FNGSGRASPP STPPPPPPPP GPPPAPYRPC AHLAFPPEPA PVNAGKAGPS AEAPKVHPKP
NSAPVAGPCS SFPKIPYSPV KATRADARKA GSSASPPAPY SPPSSRPLSS PLDELASLFN
SGRSVLRKSA AGRKIREAEG FETNMNISSR DDPSTSEITS ETQDRNANNH GIQLSNSLSS
AITAENGNSI SNGLPEEDGY SRLSISGTGT STFQRHRDSH TTQVIHQLRL SENESVALQE
LLDWRRKLCE EGQDWQQILH HAEPRVPPPP PCKKPSLLKK PEGASCNRLP SELWDTTI
