MYO1A_BOVIN
ID MYO1A_BOVIN Reviewed; 1043 AA.
AC P10568; Q2KJJ6; Q9TS38;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1989, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Unconventional myosin-Ia;
DE AltName: Full=Brush border 110 kDa protein;
DE AltName: Full=Brush border myosin I;
DE Short=BBM-I;
DE Short=BBMI;
DE AltName: Full=Myosin I heavy chain;
DE Short=MIHC;
GN Name=MYO1A; Synonyms=MYHL;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3667594; DOI=10.1016/s0021-9258(18)47842-8;
RA Hoshimaru M., Nakanishi S.;
RT "Identification of a new type of mammalian myosin heavy chain by molecular
RT cloning. Overlap of its mRNA with preprotachykinin B mRNA.";
RL J. Biol. Chem. 262:14625-14632(1987).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Crossbred X Angus; TISSUE=Ileum;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-789.
RC TISSUE=Liver;
RX PubMed=1587791; DOI=10.1093/oxfordjournals.jbchem.a123754;
RA Kawakami H., Moriyoshi K., Utsumi T., Nakanishi S.;
RT "Structural organization and expression of the gene for bovine myosin I
RT heavy chain.";
RL J. Biochem. 111:302-309(1992).
CC -!- FUNCTION: Involved in directing the movement of organelles along actin
CC filaments. {ECO:0000305}.
CC -!- PTM: Phosphorylated by ALPK1. {ECO:0000250|UniProtKB:Q9UBC5}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
CC -!- CAUTION: Represents an unconventional myosin. This protein should not
CC be confused with the conventional myosin-1 (MYH1). {ECO:0000305}.
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DR EMBL; J02819; AAA30658.1; -; mRNA.
DR EMBL; BC105312; AAI05313.1; -; mRNA.
DR PIR; A29483; A29483.
DR RefSeq; NP_776820.1; NM_174395.3.
DR RefSeq; XP_005206567.1; XM_005206510.3.
DR AlphaFoldDB; P10568; -.
DR SMR; P10568; -.
DR STRING; 9913.ENSBTAP00000019518; -.
DR PaxDb; P10568; -.
DR PeptideAtlas; P10568; -.
DR PRIDE; P10568; -.
DR Ensembl; ENSBTAT00000019518; ENSBTAP00000019518; ENSBTAG00000014655.
DR Ensembl; ENSBTAT00000075941; ENSBTAP00000068102; ENSBTAG00000014655.
DR GeneID; 281936; -.
DR KEGG; bta:281936; -.
DR CTD; 4640; -.
DR VEuPathDB; HostDB:ENSBTAG00000014655; -.
DR VGNC; VGNC:31816; MYO1A.
DR eggNOG; KOG0164; Eukaryota.
DR GeneTree; ENSGT00940000160660; -.
DR HOGENOM; CLU_000192_7_7_1; -.
DR InParanoid; P10568; -.
DR OMA; IKPNEYQ; -.
DR OrthoDB; 122881at2759; -.
DR TreeFam; TF312960; -.
DR Proteomes; UP000009136; Chromosome 5.
DR Bgee; ENSBTAG00000014655; Expressed in jejunum and 82 other tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0005903; C:brush border; ISS:UniProtKB.
DR GO; GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031941; C:filamentous actin; ISS:UniProtKB.
DR GO; GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0005902; C:microvillus; ISS:UniProtKB.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044853; C:plasma membrane raft; IEA:Ensembl.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030033; P:microvillus assembly; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR GO; GO:0051648; P:vesicle localization; ISS:UniProtKB.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR010926; Myosin_TH1.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF06017; Myosin_TH1; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 3.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51757; TH1; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; ATP-binding; Calmodulin-binding; Motor protein; Myosin;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN 1..1043
FT /note="Unconventional myosin-Ia"
FT /id="PRO_0000123437"
FT DOMAIN 8..694
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 697..719
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 720..742
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 743..772
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 858..1042
FT /note="TH1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01093"
FT REGION 571..593
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT BINDING 101..108
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT CONFLICT 242
FT /note="A -> D (in Ref. 2; AAI05313)"
FT /evidence="ECO:0000305"
FT CONFLICT 708
FT /note="Missing (in Ref. 3)"
FT /evidence="ECO:0000305"
FT CONFLICT 822
FT /note="R -> S (in Ref. 2; AAI05313)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1043 AA; 118869 MW; 581BE91EA508DB3C CRC64;
MTLLEGSVGV EDLVLLEPLE QESLIRNLQL RYEKKEIYTY IGNVLVSVNP YQQLPIYDLE
FVAKYRDYTF YELKPHIYAL ANMAYQSLRD RDRDQCILIT GESGAGKTEA SKLVMSYVAA
VCGKGEQVNS VKEQLLQSNP VLEAFGNAKT IRNNNSSRFG KYMDIEFDFK GFPLGGVITN
YLLEKSRVVK QLEGERNFHI FYQLLAGADA QLLKALKLER DTGGYAYLNP DTSRVDGMDD
DANFKVLQSA MTVIGFSDEE IRQVLEVAAL VLKLGNVELI NEFQANGVPA SGIRDGRGVQ
EIGELVGLNS VELERALCSR TMETAKEKVV TTLNVIQAQY ARDALAKNIY SRLFNWLVNR
INESIKVGTG EKRKVMGVLD IYGFEILEDN SFEQFVINYC NEKLQQVFIE MTLKEEQEEY
KREGIPWVKV EYFDNGIICN LIEHNQRGIL AMLDEECLRP GVVSDSTFLA KLNQLFSKHS
HYESKVTQNA QRQYDHSMGL SCFRICHYAG KVTYNVNSFI DKNNDLLFRD LSQAMWKARH
PLLRSLFPEG DPKQASLKRP PTAGAQFKSS VTTLMKNLYS KNPNYIRCIK PNEHQQRGHF
SFELVSVQAQ YLGLLENVRV RRAGYAYRQA YGSFLERYRL LSRSTWPRWN GGDQEGVEKV
LGELSMSSEE LAFGKTKIFI RSPKTLFYLE EQRRLRLQQL ATLIQKTYRG WRCRTHYQLM
RKSQIVISSW FRGNMQKKHY RKMKASALLI QAFVRGWKAR KNYRKYFRSG AALILSNFIY
KSMVQKFLLG LKNDLPSPSI LDKKWPSAPY KYFNTANHEL QRLFHQWKCK KFRDQLSPKQ
VEVLREKLCA SELFKGKKAS YPQSVPIPFH GDYIGLQRNP KLQKLKGGEE GPILMAETVV
KVNRGNAKTS SRILLLTKGH VIITDMKNPQ AKTVIPLNSL AGVSVTSFKD GLFSLHLSEI
SSVGSKGEFL LVSEHVIELL TKICRATLDA TQMQLPVTVT EEFSVKFKEG SLTVKVIQGP
GGGGTGKLSF KKKGSRCLEV TVQ
