MYO1A_RAT
ID MYO1A_RAT Reviewed; 842 AA.
AC Q62774;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Unconventional myosin-Ia;
DE AltName: Full=Brush border myosin I;
DE Short=BBM-I;
DE Short=BBMI;
DE AltName: Full=Myosin I heavy chain;
DE Short=MIHC;
DE Flags: Fragment;
GN Name=Myo1a; Synonyms=Bbmi, Myhl;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Liver, and Testis;
RX PubMed=7779104; DOI=10.1006/bbrc.1995.1815;
RA Balish M.F., Coluccio L.M.;
RT "Identification of brush border myosin-I in liver and testis.";
RL Biochem. Biophys. Res. Commun. 211:331-339(1995).
CC -!- FUNCTION: Involved in directing the movement of organelles along actin
CC filaments. {ECO:0000305}.
CC -!- PTM: Phosphorylated by ALPK1. {ECO:0000250|UniProtKB:Q9UBC5}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
CC -!- CAUTION: Represents an unconventional myosin. This protein should not
CC be confused with the conventional myosin-1 (MYH1). {ECO:0000305}.
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DR EMBL; U25148; AAA89132.1; -; mRNA.
DR AlphaFoldDB; Q62774; -.
DR SMR; Q62774; -.
DR STRING; 10116.ENSRNOP00000005575; -.
DR jPOST; Q62774; -.
DR PaxDb; Q62774; -.
DR PRIDE; Q62774; -.
DR UCSC; RGD:3135; rat.
DR RGD; 3135; Myo1a.
DR eggNOG; KOG0164; Eukaryota.
DR InParanoid; Q62774; -.
DR PhylomeDB; Q62774; -.
DR Proteomes; UP000002494; Unplaced.
DR GO; GO:0015629; C:actin cytoskeleton; IDA:RGD.
DR GO; GO:0016324; C:apical plasma membrane; ISO:RGD.
DR GO; GO:0009925; C:basal plasma membrane; ISO:RGD.
DR GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0005903; C:brush border; IDA:RGD.
DR GO; GO:0031252; C:cell leading edge; IDA:RGD.
DR GO; GO:0030864; C:cortical actin cytoskeleton; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0031941; C:filamentous actin; ISS:UniProtKB.
DR GO; GO:0030426; C:growth cone; IDA:RGD.
DR GO; GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
DR GO; GO:0045121; C:membrane raft; IDA:RGD.
DR GO; GO:0005902; C:microvillus; ISS:UniProtKB.
DR GO; GO:0016459; C:myosin complex; TAS:RGD.
DR GO; GO:0043005; C:neuron projection; IDA:RGD.
DR GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0044853; C:plasma membrane raft; ISO:RGD.
DR GO; GO:0051015; F:actin filament binding; ISO:RGD.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030030; P:cell projection organization; ISO:RGD.
DR GO; GO:0030034; P:microvillar actin bundle assembly; NAS:RGD.
DR GO; GO:0030033; P:microvillus assembly; ISO:RGD.
DR GO; GO:0032880; P:regulation of protein localization; IMP:RGD.
DR GO; GO:0007605; P:sensory perception of sound; ISS:UniProtKB.
DR GO; GO:0051648; P:vesicle localization; ISS:UniProtKB.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd01378; MYSc_Myo1; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036072; MYSc_Myo1.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00015; IQ; 3.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; ATP-binding; Calmodulin-binding; Motor protein; Myosin;
KW Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat.
FT CHAIN <1..>842
FT /note="Unconventional myosin-Ia"
FT /id="PRO_0000123440"
FT DOMAIN <1..686
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 689..712
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 713..733
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 735..764
FT /note="IQ 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT REGION 563..585
FT /note="Actin-binding"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT BINDING 93..100
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT NON_TER 1
FT NON_TER 842
SQ SEQUENCE 842 AA; 97211 MW; DDAFDCB66308316B CRC64;
GVEDLILLEP LDEESLIKNL QLRYEKKEIY TYIGNVVISM NPYQQLPIYG PEFIAKYRDY
TFYELKPHIY ALANVAYQSL KDRDRDQCIL ITGESGAGKT EASKLVMSYV AAVCGKGEQV
NSVKEQLLQS NPVLEAFGNA KTIRNDNSSR FGKYMDIEFD FKGSPLGGVI TNYLLEKSRV
VKQLKGERNF HIFYQLLAGA DTQLLKALKL EEDARGYAYL NGEVSRVNGM DDASNFRAVQ
NAMAVIGFSE EEIRQVLEVT ALVLKLGNVK LAGEFQANGL PASGVCDGKG IQEIGEMMGL
NSVELEKALS SRTMETGKEK VVTVLNVIQA QYARDALAKN IYSRLFDWIV NRINESIKVG
TGEKRKVMGV LDIYGFEILE DNSFEQFVIN YCNEKLQQVF IELTLKEEQE EYKREGIPWT
KVEYFDNGII CDLIEHSQRG ILAMLDEECL RPGVVSDTTF LAKLNQLFSK HSHYESKVTQ
NAQRQYDRTM GLSCFRICHY AGKVTYDVTS FIDKNNDLLF RDLSQTMWKA QHPLLHSLFP
RGNPKEASPK RPPTAGTQFK NSVAILMKNL YSKNPNYIRC IKPNDQQQQG RFTSELVMVQ
ARYLGLLENV RVRRAGYAFR QAYKPFLERY RLLSRSTWPR WNGEDREGVE KVLGSLILSS
EELAYGRTKI FIRSPKTLFY LEEQRRLRLQ QLATLIQKVY RGWRCRTHYQ QMRKSQILLS
AWFRGNKQKK HYGKIRSSVL LIQAFVRGWK ARKNYRKYFR SGARITLANF IYQSITQKFL
LNLKKNLPST KVLDNTWPAA PYRCFNTANQ ELQHLFYQWK CKKYRDQLSP KQVQTLREKL
CA
