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MYO9_ARATH
ID   MYO9_ARATH              Reviewed;        1538 AA.
AC   F4HXP9; Q9FRR5;
DT   26-JUN-2013, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Myosin-9;
DE   AltName: Full=Myosin XI C;
DE            Short=AtXIC;
GN   Name=XI-C; Synonyms=XIC; OrderedLocusNames=At1g08730; ORFNames=F22O13.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1078-1538.
RC   STRAIN=cv. Columbia;
RX   PubMed=14993207; DOI=10.1101/gr.1515604;
RA   Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA   Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA   Weissenbach J., Salanoubat M.;
RT   "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT   combined approach to evaluate and improve Arabidopsis genome annotation.";
RL   Genome Res. 14:406-413(2004).
RN   [4]
RP   GENE FAMILY.
RX   PubMed=10984423; DOI=10.1242/jcs.113.19.3353;
RA   Hodge T., Cope M.J.;
RT   "A myosin family tree.";
RL   J. Cell Sci. 113:3353-3354(2000).
RN   [5]
RP   GENE FAMILY.
RX   PubMed=11516337; DOI=10.1186/gb-2001-2-7-research0024;
RA   Reddy A.S., Day I.S.;
RT   "Analysis of the myosins encoded in the recently completed Arabidopsis
RT   thaliana genome sequence.";
RL   Genome Biol. 2:RESEARCH0024.1-RESEARCH0024.17(2001).
RN   [6]
RP   FUNCTION.
RX   PubMed=19369591; DOI=10.1104/pp.109.136853;
RA   Avisar D., Abu-Abied M., Belausov E., Sadot E., Hawes C., Sparkes I.A.;
RT   "A comparative study of the involvement of 17 Arabidopsis myosin family
RT   members on the motility of Golgi and other organelles.";
RL   Plant Physiol. 150:700-709(2009).
RN   [7]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=21233331; DOI=10.1104/pp.110.170720;
RA   Peremyslov V.V., Mockler T.C., Filichkin S.A., Fox S.E., Jaiswal P.,
RA   Makarova K.S., Koonin E.V., Dolja V.V.;
RT   "Expression, splicing, and evolution of the myosin gene family in plants.";
RL   Plant Physiol. 155:1191-1204(2011).
RN   [8]
RP   FUNCTION.
RX   PubMed=21914656; DOI=10.1093/jxb/err265;
RA   Avisar D., Abu-Abied M., Belausov E., Sadot E.;
RT   "Myosin XIK is a major player in cytoplasm dynamics and is regulated by two
RT   amino acids in its tail.";
RL   J. Exp. Bot. 63:241-249(2012).
CC   -!- FUNCTION: Myosin heavy chain that is required for the cell cycle-
CC       regulated transport of various organelles and proteins for their
CC       segregation. Functions by binding with its tail domain to receptor
CC       proteins on organelles and exerting force with its N-terminal motor
CC       domain against actin filaments, thereby transporting its cargo along
CC       polarized actin cables. Involved in trafficking of Golgi stacks and
CC       mitochondria. {ECO:0000269|PubMed:19369591,
CC       ECO:0000269|PubMed:21914656}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- DOMAIN: IQ domain mediates interaction with calmodulin. {ECO:0000250}.
CC   -!- DOMAIN: The tail domain is a globular cargo-binding domain.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Myosin family. Plant myosin class XI subfamily.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF99762.1; Type=Erroneous gene model prediction; Note=The predicted gene has been split into 2 genes: At1g08720 and At1g08730.; Evidence={ECO:0000305};
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DR   EMBL; AC003981; AAF99762.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002684; AEE28340.1; -; Genomic_DNA.
DR   EMBL; BX816587; -; NOT_ANNOTATED_CDS; mRNA.
DR   PIR; T00727; T00727.
DR   RefSeq; NP_172349.2; NM_100746.3.
DR   AlphaFoldDB; F4HXP9; -.
DR   SMR; F4HXP9; -.
DR   STRING; 3702.AT1G08730.1; -.
DR   iPTMnet; F4HXP9; -.
DR   PaxDb; F4HXP9; -.
DR   PRIDE; F4HXP9; -.
DR   EnsemblPlants; AT1G08730.1; AT1G08730.1; AT1G08730.
DR   GeneID; 837394; -.
DR   Gramene; AT1G08730.1; AT1G08730.1; AT1G08730.
DR   KEGG; ath:AT1G08730; -.
DR   Araport; AT1G08730; -.
DR   TAIR; locus:2025535; AT1G08730.
DR   eggNOG; KOG0160; Eukaryota.
DR   HOGENOM; CLU_000192_3_0_1; -.
DR   InParanoid; F4HXP9; -.
DR   OMA; CRWRGKI; -.
DR   OrthoDB; 311886at2759; -.
DR   PRO; PR:F4HXP9; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; F4HXP9; baseline and differential.
DR   Genevisible; F4HXP9; AT.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0016459; C:myosin complex; ISS:TAIR.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:cytoskeletal motor activity; ISS:TAIR.
DR   GO; GO:0000146; F:microfilament motor activity; IMP:TAIR.
DR   GO; GO:0007015; P:actin filament organization; IGI:TAIR.
DR   GO; GO:0030048; P:actin filament-based movement; TAS:TAIR.
DR   GO; GO:0051640; P:organelle localization; IGI:TAIR.
DR   GO; GO:0009860; P:pollen tube growth; IGI:TAIR.
DR   GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR   CDD; cd15475; MyosinXI_CBD; 1.
DR   CDD; cd01384; MYSc_Myo11; 1.
DR   Gene3D; 3.40.850.10; -; 1.
DR   InterPro; IPR002710; Dilute_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR004009; Myosin_N.
DR   InterPro; IPR037975; MyosinXI_CBD.
DR   InterPro; IPR036018; MYSc_Myo11.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF01843; DIL; 1.
DR   Pfam; PF00612; IQ; 2.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF02736; Myosin_N; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM01132; DIL; 1.
DR   SMART; SM00015; IQ; 6.
DR   SMART; SM00242; MYSc; 1.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   PROSITE; PS51126; DILUTE; 1.
DR   PROSITE; PS50096; IQ; 6.
DR   PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR   PROSITE; PS51844; SH3_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; ATP-binding; Calmodulin-binding; Coiled coil; Motor protein;
KW   Myosin; Nucleotide-binding; Reference proteome; Repeat.
FT   CHAIN           1..1538
FT                   /note="Myosin-9"
FT                   /id="PRO_0000422864"
FT   DOMAIN          16..65
FT                   /note="Myosin N-terminal SH3-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01190"
FT   DOMAIN          70..740
FT                   /note="Myosin motor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT   DOMAIN          743..772
FT                   /note="IQ 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          766..795
FT                   /note="IQ 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          791..820
FT                   /note="IQ 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          814..843
FT                   /note="IQ 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          839..868
FT                   /note="IQ 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          862..891
FT                   /note="IQ 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT   DOMAIN          1168..1481
FT                   /note="Dilute"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00503"
FT   REGION          503..537
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000255"
FT   REGION          539..562
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000255"
FT   REGION          597..621
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000255"
FT   REGION          621..643
FT                   /note="Actin-binding"
FT                   /evidence="ECO:0000250"
FT   REGION          1017..1041
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1098..1121
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          892..1064
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1098..1119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         164..171
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
FT   BINDING         217..225
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1538 AA;  174626 MW;  EA7866D11EBC8F7A CRC64;
     MVRECFTFLN IFVLHSIGSH VWFEDPEVAW IDGEVEKING QEVVIQATTG KKVTAKLSKI
     YPKDVEAPAG GVDDMTKLSY LHEPGVLQNL KIRYELNEIY TYTGNILIAI NPFQRLPHIY
     DAHMMQQYKG APLGELSPHV FAVADVAYRA MINEGKSNSI LVSGESGAGK TETTKMLMRY
     LAYLGGRAVT EGRTVEQQVL ESNPVLEAFG NAKTVRNNNS SRFGKFVEIQ FDKQGRISGA
     AIRTYLLERS RVCQISDPER NYHCFYLLCA APQEEIEKYK LGHPKTFHYL NQSKCFELVG
     ISDAHDYLAT RRAMDIVGIS EKEQEAIFRV VAAILHIGNI DFTKGKEVDS SVPKDEKSKF
     HLKTAAELLM CDLKALEDAL CKRVMITPEE VIKRSLDPQS AVTSRDGLAK TVYSRLFDWL
     VDKINKSIGQ DANSRSLIGV LDIYGFESFK TNSFEQFCIN FTNEKLQQHF NQHVFKMEQE
     EYTKEAIDWS YIEFVDNQDV LDLIEKKPGG IVALLDEACM FPKSTHETFA NKLYQTFKTH
     KRFIKPKLSR TDFAVAHYAG EVLYQSELFL DKNKDYVIPE HQDLLGASKC PFVVGLFPPL
     PEETSKSSKF SSIGSRFKLQ LQQLMETLNC TEPHYIRCVK PNNLLKPAIF ENVNIMQQLR
     CGGVLEAIRI SCAGYPTRKP FFEFINRFGL LSPAALEGNF DEKVACQKIL DNMGLKGYQI
     GKTKVFLRAG QMAELDARRA EVLSSAAKKI QRRIRTHQAQ KRFIVLRKAT ISLQAICRGR
     LSCKHYDNLR REAAAVKIQK NGRRHYSRKS YKKLHVASLV VQTGLRAMAA RKQFRFRKQT
     KAATIVQAQW RCHRAISYYK KLKNGVVLSQ TRWRGRLAKR ELRKLKMAAR ETGALKEAKD
     MLEKKVEELT YRVQLEKRSR GDLEEAKTQE ILKLKSSFEE MRKKVDETNA LLLKEREAAK
     KAAEEAPPVI KETQILVEDT KKIELMTEEL ESVKVTLENE KQRADDAVRK FEEAQESLED
     KKKKLEETEK KGQQLQESLT RMEEKCSNLE SENKVLRQQA VSMAPNKFLS GRSRSILQRG
     SESGHLAVDA RSNLDLHSHS INHRDPSEVE DKPQKSLNEK QQENQDLLIR SIVQHLGFQG
     NRPITACIIY KCLLQWRSFE VERTSVFDRI IQTIGHAIET QDNNNTLAYW LSNTSTLLLL
     LQRTLKASGA AGMAPQRRRS SSATLFGRMS QSFRGAPPGV NLAMINGAAG GGADTFRQVE
     AKYPALLFKQ QLTAYVEKIY GMIRDNLKKE ISPLLGLCIQ APRTSRASLV KGASRSVGNT
     AAQQALIAHW QGIVKSLTNF LNTLKSNNVP SFLVRKVFTQ IFSFINVQLF NSLLLRRECC
     SFSNGEYVKA GLSELEHWCF KATNEYAGSS WDELKHIRQA IGFLVVHQKP KKTLDEISHD
     LCPVLSIQQL YRISTMYWDD KYGTHSVSPD VIANMRVLMT EDSNNAVSNS FLLDDDSSIP
     FSVDDLSKSM EKFEIADIEP PPLIRENSGF SFLLPVSE
 
 
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