MYOA_PLAF7
ID MYOA_PLAF7 Reviewed; 818 AA.
AC Q8IDR3;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Myosin-A;
DE AltName: Full=PfMyoA;
GN Name=MyoA {ECO:0000305}; ORFNames=PF13_0233, PF3D7_1342600;
OS Plasmodium falciparum (isolate 3D7).
OC Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida;
OC Plasmodiidae; Plasmodium; Plasmodium (Laverania).
OX NCBI_TaxID=36329;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368864; DOI=10.1038/nature01097;
RA Gardner M.J., Hall N., Fung E., White O., Berriman M., Hyman R.W.,
RA Carlton J.M., Pain A., Nelson K.E., Bowman S., Paulsen I.T., James K.D.,
RA Eisen J.A., Rutherford K.M., Salzberg S.L., Craig A., Kyes S., Chan M.-S.,
RA Nene V., Shallom S.J., Suh B., Peterson J., Angiuoli S., Pertea M.,
RA Allen J., Selengut J., Haft D., Mather M.W., Vaidya A.B., Martin D.M.A.,
RA Fairlamb A.H., Fraunholz M.J., Roos D.S., Ralph S.A., McFadden G.I.,
RA Cummings L.M., Subramanian G.M., Mungall C., Venter J.C., Carucci D.J.,
RA Hoffman S.L., Newbold C., Davis R.W., Fraser C.M., Barrell B.G.;
RT "Genome sequence of the human malaria parasite Plasmodium falciparum.";
RL Nature 419:498-511(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=3D7;
RX PubMed=12368867; DOI=10.1038/nature01095;
RA Hall N., Pain A., Berriman M., Churcher C.M., Harris B., Harris D.,
RA Mungall K.L., Bowman S., Atkin R., Baker S., Barron A., Brooks K.,
RA Buckee C.O., Burrows C., Cherevach I., Chillingworth C., Chillingworth T.,
RA Christodoulou Z., Clark L., Clark R., Corton C., Cronin A., Davies R.M.,
RA Davis P., Dear P., Dearden F., Doggett J., Feltwell T., Goble A.,
RA Goodhead I., Gwilliam R., Hamlin N., Hance Z., Harper D., Hauser H.,
RA Hornsby T., Holroyd S., Horrocks P., Humphray S., Jagels K., James K.D.,
RA Johnson D., Kerhornou A., Knights A., Konfortov B., Kyes S., Larke N.,
RA Lawson D., Lennard N., Line A., Maddison M., Mclean J., Mooney P.,
RA Moule S., Murphy L., Oliver K., Ormond D., Price C., Quail M.A.,
RA Rabbinowitsch E., Rajandream M.A., Rutter S., Rutherford K.M., Sanders M.,
RA Simmonds M., Seeger K., Sharp S., Smith R., Squares R., Squares S.,
RA Stevens K., Taylor K., Tivey A., Unwin L., Whitehead S., Woodward J.R.,
RA Sulston J.E., Craig A., Newbold C., Barrell B.G.;
RT "Sequence of Plasmodium falciparum chromosomes 1, 3-9 and 13.";
RL Nature 419:527-531(2002).
RN [3]
RP DEVELOPMENTAL STAGE, IDENTIFICATION BY MASS SPECTROMETRY, AND
RP PHOSPHORYLATION AT SER-19.
RX PubMed=26149123; DOI=10.1038/ncomms8285;
RA Alam M.M., Solyakov L., Bottrill A.R., Flueck C., Siddiqui F.A., Singh S.,
RA Mistry S., Viskaduraki M., Lee K., Hopp C.S., Chitnis C.E., Doerig C.,
RA Moon R.W., Green J.L., Holder A.A., Baker D.A., Tobin A.B.;
RT "Phosphoproteomics reveals malaria parasite Protein Kinase G as a
RT signalling hub regulating egress and invasion.";
RL Nat. Commun. 6:7285-7285(2015).
CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity.
CC Unconventional myosins serve in intracellular movements. Their highly
CC divergent tails are presumed to bind to membranous compartments, which
CC would be moved relative to actin filaments (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Peripheral membrane
CC protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Tightly
CC associated with the plasma membrane. {ECO:0000250}.
CC -!- DEVELOPMENTAL STAGE: Expressed during the parasite blood stage (at
CC protein level). {ECO:0000269|PubMed:26149123}.
CC -!- DOMAIN: This protein differs from the typical myosin heavy chain
CC structure in having head and tail domains but no discernible neck
CC domain.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
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DR EMBL; AL844509; CAD52556.1; -; Genomic_DNA.
DR RefSeq; XP_001350147.1; XM_001350111.1.
DR PDB; 4AOM; X-ray; 1.94 A; T=799-816.
DR PDB; 4MZJ; X-ray; 1.47 A; T=799-816.
DR PDB; 4MZK; X-ray; 1.82 A; T=799-816.
DR PDB; 4MZL; X-ray; 2.01 A; C/D=800-816.
DR PDB; 4R1E; X-ray; 1.98 A; B=803-816.
DR PDB; 6I7D; X-ray; 2.82 A; A/B/C/D=1-768.
DR PDB; 6I7E; X-ray; 3.49 A; A=1-768.
DR PDB; 6TU7; EM; 3.10 A; AP1/GP1=2-818.
DR PDB; 6YCX; X-ray; 3.99 A; A/B=1-818.
DR PDB; 6YCY; X-ray; 2.55 A; A=1-818.
DR PDB; 6YCZ; X-ray; 3.27 A; A=1-818.
DR PDB; 6ZN3; X-ray; 2.51 A; C/F/I/L/O=775-816.
DR PDB; 7ALN; EM; 3.77 A; F=1-818.
DR PDBsum; 4AOM; -.
DR PDBsum; 4MZJ; -.
DR PDBsum; 4MZK; -.
DR PDBsum; 4MZL; -.
DR PDBsum; 4R1E; -.
DR PDBsum; 6I7D; -.
DR PDBsum; 6I7E; -.
DR PDBsum; 6TU7; -.
DR PDBsum; 6YCX; -.
DR PDBsum; 6YCY; -.
DR PDBsum; 6YCZ; -.
DR PDBsum; 6ZN3; -.
DR PDBsum; 7ALN; -.
DR AlphaFoldDB; Q8IDR3; -.
DR SASBDB; Q8IDR3; -.
DR SMR; Q8IDR3; -.
DR BioGRID; 1209455; 4.
DR IntAct; Q8IDR3; 4.
DR STRING; 5833.PF13_0233; -.
DR PRIDE; Q8IDR3; -.
DR EnsemblProtists; CAD52556; CAD52556; PF3D7_1342600.
DR GeneID; 814200; -.
DR KEGG; pfa:PF3D7_1342600; -.
DR VEuPathDB; PlasmoDB:PF3D7_1342600; -.
DR HOGENOM; CLU_000192_7_5_1; -.
DR InParanoid; Q8IDR3; -.
DR OMA; NGIMEAR; -.
DR PhylomeDB; Q8IDR3; -.
DR Proteomes; UP000001450; Chromosome 13.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0070258; C:inner membrane pellicle complex; IDA:GeneDB.
DR GO; GO:0016459; C:myosin complex; IDA:GeneDB.
DR GO; GO:0020039; C:pellicle; IDA:GeneDB.
DR GO; GO:0005886; C:plasma membrane; IDA:GeneDB.
DR GO; GO:0003779; F:actin binding; IDA:GeneDB.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IDA:GeneDB.
DR GO; GO:0003774; F:cytoskeletal motor activity; ISS:GeneDB.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd14876; MYSc_Myo14; 1.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR036044; MYSc_Myo14.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Actin-binding; ATP-binding; Cell membrane; Membrane;
KW Motor protein; Myosin; Nucleotide-binding; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..818
FT /note="Myosin-A"
FT /id="PRO_0000123374"
FT DOMAIN 97..771
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT REGION 661..671
FT /note="Actin-binding"
FT /evidence="ECO:0000255"
FT REGION 773..818
FT /note="Tail"
FT BINDING 191..198
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
FT MOD_RES 19
FT /note="Phosphoserine; by PKG"
FT /evidence="ECO:0000269|PubMed:26149123"
FT HELIX 5..14
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:6I7E"
FT STRAND 35..39
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 42..46
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 63..72
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 80..82
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 84..86
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 87..89
FT /evidence="ECO:0007829|PDB:6I7D"
FT HELIX 96..98
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 102..104
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 110..121
FT /evidence="ECO:0007829|PDB:6YCY"
FT TURN 122..124
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 127..130
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 133..137
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 148..156
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 160..162
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 167..181
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 185..192
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 197..208
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 212..214
FT /evidence="ECO:0007829|PDB:6I7E"
FT HELIX 218..235
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 248..256
FT /evidence="ECO:0007829|PDB:6YCY"
FT TURN 258..260
FT /evidence="ECO:0007829|PDB:6I7E"
FT STRAND 262..270
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 274..277
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 288..296
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 299..305
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 310..312
FT /evidence="ECO:0007829|PDB:6YCZ"
FT STRAND 314..316
FT /evidence="ECO:0007829|PDB:6I7E"
FT STRAND 318..320
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 328..341
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 346..362
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 367..369
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 372..375
FT /evidence="ECO:0007829|PDB:6I7E"
FT STRAND 379..381
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 383..385
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 386..395
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 400..408
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 409..414
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 417..422
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 425..455
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 465..471
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 477..479
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 481..511
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 525..532
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 533..537
FT /evidence="ECO:0007829|PDB:6I7D"
FT HELIX 538..547
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 548..550
FT /evidence="ECO:0007829|PDB:6I7E"
FT HELIX 553..563
FT /evidence="ECO:0007829|PDB:6YCY"
FT TURN 564..566
FT /evidence="ECO:0007829|PDB:6I7D"
FT STRAND 570..572
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 574..576
FT /evidence="ECO:0007829|PDB:6I7D"
FT STRAND 577..585
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 588..593
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 597..601
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 607..614
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 619..624
FT /evidence="ECO:0007829|PDB:6YCY"
FT TURN 625..627
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 637..639
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 641..657
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 659..667
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 680..689
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 692..700
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 701..703
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 705..708
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 709..715
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 717..719
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 721..724
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 727..729
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 731..742
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 746..748
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 749..751
FT /evidence="ECO:0007829|PDB:6YCY"
FT STRAND 753..758
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 760..773
FT /evidence="ECO:0007829|PDB:6YCY"
FT HELIX 775..798
FT /evidence="ECO:0007829|PDB:6ZN3"
FT HELIX 801..815
FT /evidence="ECO:0007829|PDB:4MZJ"
SQ SEQUENCE 818 AA; 92277 MW; F397875C52B3B19E CRC64;
MAVTNEEIKT ASKIVRRVSN VEAFDKSGSV FKGYQIWTDI SPTIENDPNI MFVKCVVQQG
SKKEKLTVVQ IDPPGTGTPY DIDPTHAWNC NSQVDPMSFG DIGLLNHTNI PCVLDFLKHR
YLKNQIYTTA VPLIVAINPY KDLGNTTNEW IRRYRDTADH TKLPPHVFTC AREALSNLHG
VNKSQTIIVS GESGAGKTEA TKQIMRYFAS SKSGNMDLRI QTAIMAANPV LEAFGNAKTI
RNNNSSRFGR FMQLVISHEG GIRYGSVVAF LLEKSRIITQ DDNERSYHIF YQFLKGANST
MKSKFGLKGV TEYKLLNPNS TEVSGVDDVK DFEEVIESLK NMELSESDIE VIFSIVAGIL
TLGNVRLIEK QEAGLSDAAA IMDEDMGVFN KACELMYLDP ELIKREILIK VTVAGGTKIE
GRWNKNDAEV LKSSLCKAMY EKLFLWIIRH LNSRIEPEGG FKTFMGMLDI FGFEVFKNNS
LEQLFINITN EMLQKNFVDI VFERESKLYK DEGISTAELK YTSNKEVINV LCEKGKSVLS
YLEDQCLAPG GTDEKFVSSC ATNLKENNKF TPAKVASNKN FIIQHTIGPI QYCAESFLLK
NKDVLRGDLV EVIKDSPNPI VQQLFEGQVI EKGKIAKGSL IGSQFLNQLT SLMNLINSTE
PHFIRCIKPN ENKKPLEWCE PKILIQLHAL SILEALVLRQ LGYSYRRTFE EFLYQYKFVD
IAAAEDSSVE NQNKCVNILK LSGLSESMYK IGKSMVFLKQ EGAKILTKIQ REKLVEWENC
VSVIEAAILK HKYKQKVNKN IPSLLRVQAH IRKKMVAQ
