MYOD1_DANRE
ID MYOD1_DANRE Reviewed; 275 AA.
AC Q90477; Q29RD1; Q98TY7;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 2.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Myoblast determination protein 1 homolog;
DE AltName: Full=Myogenic factor 1;
GN Name=myod1; Synonyms=myod;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=8565839; DOI=10.1242/dev.122.1.271;
RA Weinberg E.S., Allende M.L., Kelly C.S., Abdelhamid A., Murakami T.,
RA Andermann P., Doerre O.G., Grunwald D.J., Riggleman B.;
RT "Developmental regulation of zebrafish MyoD in wild-type, no tail and
RT spadetail embryos.";
RL Development 122:271-280(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX PubMed=12524040; DOI=10.1016/s1096-4959(02)00194-x;
RA Du S.J., Gao J., Anyangwe V.;
RT "Muscle-specific expression of myogenin in zebrafish embryos is controlled
RT by multiple regulatory elements in the promoter.";
RL Comp. Biochem. Physiol. 134B:123-134(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May act as a transcriptional activator that promotes
CC transcription of muscle-specific target genes and plays a role in
CC muscle differentiation. {ECO:0000250}.
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- INTERACTION:
CC Q90477; Q90463: her1; NbExp=2; IntAct=EBI-16009646, EBI-16009629;
CC Q90477; Q9I9K1: her7; NbExp=2; IntAct=EBI-16009646, EBI-16009727;
CC Q90477; Q6P0J1: hes6; NbExp=2; IntAct=EBI-16009646, EBI-16009592;
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- TISSUE SPECIFICITY: From mid-gastrula to just before somite formation,
CC expressed in cells adjacent to axial mesoderm. Subsequently, during the
CC anterior-to-posterior wave of somite formation and maturation,
CC expressed within particular regions of each somite. Expressed in both
CC muscle and non-muscle cells. {ECO:0000269|PubMed:12524040,
CC ECO:0000269|PubMed:8565839}.
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DR EMBL; Z36945; CAA85407.1; -; mRNA.
DR EMBL; AF318503; AAK06755.1; -; Genomic_DNA.
DR EMBL; BC114261; AAI14262.1; -; mRNA.
DR PIR; S47325; S47325.
DR RefSeq; NP_571337.2; NM_131262.2.
DR AlphaFoldDB; Q90477; -.
DR SMR; Q90477; -.
DR DIP; DIP-59871N; -.
DR IntAct; Q90477; 3.
DR STRING; 7955.ENSDARP00000009713; -.
DR PaxDb; Q90477; -.
DR Ensembl; ENSDART00000027661; ENSDARP00000009713; ENSDARG00000030110.
DR GeneID; 30513; -.
DR KEGG; dre:30513; -.
DR CTD; 4654; -.
DR ZFIN; ZDB-GENE-980526-561; myod1.
DR eggNOG; KOG3960; Eukaryota.
DR GeneTree; ENSGT00950000182959; -.
DR HOGENOM; CLU_066887_0_0_1; -.
DR InParanoid; Q90477; -.
DR OMA; GPMEMTE; -.
DR OrthoDB; 1471470at2759; -.
DR PhylomeDB; Q90477; -.
DR TreeFam; TF316344; -.
DR Reactome; R-DRE-525793; Myogenesis.
DR PRO; PR:Q90477; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 25.
DR Bgee; ENSDARG00000030110; Expressed in adaxial cell (Danio) and 80 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:ZFIN.
DR GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0002074; P:extraocular skeletal muscle development; IMP:ZFIN.
DR GO; GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
DR GO; GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
DR GO; GO:0007517; P:muscle organ development; IMP:ZFIN.
DR GO; GO:0043282; P:pharyngeal muscle development; IMP:ZFIN.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; IBA:GO_Central.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; IBA:GO_Central.
DR GO; GO:1905382; P:positive regulation of snRNA transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IGI:ZFIN.
DR GO; GO:0048741; P:skeletal muscle fiber development; IMP:ZFIN.
DR GO; GO:0007519; P:skeletal muscle tissue development; IGI:ZFIN.
DR GO; GO:0055002; P:striated muscle cell development; IGI:ZFIN.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR022032; Myf5.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF12232; Myf5; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..275
FT /note="Myoblast determination protein 1 homolog"
FT /id="PRO_0000127367"
FT DOMAIN 84..135
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 234..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 150
FT /note="L -> M (in Ref. 1; CAA85407)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="M -> I (in Ref. 2; AAK06755)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="T -> A (in Ref. 1; CAA85407)"
FT /evidence="ECO:0000305"
FT CONFLICT 235
FT /note="G -> A (in Ref. 1; CAA85407)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="E -> G (in Ref. 1; CAA85407)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 275 AA; 30936 MW; 7BFC1513BC4F6698 CRC64;
MELSDIPFPI PSADDFYDDP CFNTNDMHFF EDLDPRLVHV SLLKPDEHHH IEDEHVRAPS
GHHQAGRCLL WACKACKRKT TNADRRKAAT MRERRRLSKV NDAFETLKRC TSTNPNQRLP
KVEILRNAIS YIESLQALLR SQEDNYYPVL EHYSGDSDAS SPRSNCSDGM MDFMGPTCQT
RRRNSYDSSY FNDTPNADAR NNKNSVVSSL DCLSSIVERI STETPACPVL SVPEGHEESP
CSPHEGSVLS DTGTTAPSPT SCPQQQAQET IYQVL
