ID   MYOD2_ONCMY             Reviewed;         275 AA.
AC   Q91206;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Myoblast determination protein 1 homolog 2;
DE   AltName: Full=Myogenic factor 1-2;
GN   Name=myod2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Muscle;
RX   PubMed=8925439; DOI=10.1016/0305-0491(95)02087-x;
RA   Rescan P.Y., Gauvry L.;
RT   "Genome of the rainbow trout (Oncorhynchus mykiss) encodes two distinct
RT   muscle regulatory factors with homology to myoD.";
RL   Comp. Biochem. Physiol. 113B:711-715(1996).
CC   -!- FUNCTION: May act as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
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DR   EMBL; Z46924; CAA87032.1; -; mRNA.
DR   PIR; S51641; S51641.
DR   RefSeq; NP_001118200.1; NM_001124728.1.
DR   AlphaFoldDB; Q91206; -.
DR   SMR; Q91206; -.
DR   GeneID; 100136782; -.
DR   KEGG; omy:100136782; -.
DR   CTD; 100136782; -.
DR   OrthoDB; 1471470at2759; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:1905382; P:positive regulation of snRNA transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Transcription; Transcription regulation.
FT   CHAIN           1..275
FT                   /note="Myoblast determination protein 1 homolog 2"
FT                   /id="PRO_0000127369"
FT   DOMAIN          84..135
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          232..275
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..268
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   275 AA;  30507 MW;  BB64ACD7B93231A6 CRC64;
     MELSDISFPV TSADDFYDDP CFNTSDMHFF EDLDPRLVHV GLLKPDDHHY NEDEHIRAPS
     GHHQAGRCLL WACKACKRKT TNSDRRKAAT MRERRRLGKV NDAFENLKRC TSNNPNQRLP
     KVEILRNAIS YIESLQSLLR GQDGENYYPV LEHYSGDSDA SSPQSNCSDG MMDYNAPTCT
     SARRSNYDSS YFAETPNADS RSNKNAAVSS LDCLSNIVER ISTDTSACTV LSGQEGSEGS
     PCSPQEGSIL SRNGGTVPSP TNCPQPSHDP IYQVL