ID   MYODB_XENLA             Reviewed;         287 AA.
AC   P16076;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1990, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Myoblast determination protein 1 homolog B;
DE   AltName: Full=Myogenic factor 25;
GN   Name=myod1-b; Synonyms=mf25;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1690844; DOI=10.1128/mcb.10.4.1516-1524.1990;
RA   Scales J.B., Olson E.N., Perry M.;
RT   "Two distinct Xenopus genes with homology to MyoD1 are expressed before
RT   somite formation in early embryogenesis.";
RL   Mol. Cell. Biol. 10:1516-1524(1990).
CC   -!- FUNCTION: May act as a transcriptional activator that promotes
CC       transcription of muscle-specific target genes and plays a role in
CC       muscle differentiation. {ECO:0000250}.
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR   EMBL; M31118; AAA49902.1; -; mRNA.
DR   PIR; C34783; C34783.
DR   AlphaFoldDB; P16076; -.
DR   SMR; P16076; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR   GO; GO:0070888; F:E-box binding; ISS:UniProtKB.
DR   GO; GO:1990841; F:promoter-specific chromatin binding; ISS:UniProtKB.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR   GO; GO:0043966; P:histone H3 acetylation; ISS:UniProtKB.
DR   GO; GO:0043967; P:histone H4 acetylation; ISS:UniProtKB.
DR   GO; GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.
DR   GO; GO:1905382; P:positive regulation of snRNA transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR022032; Myf5.
DR   InterPro; IPR002546; MyoD_N.
DR   InterPro; IPR039704; Myogenic_factor.
DR   PANTHER; PTHR11534; PTHR11534; 1.
DR   Pfam; PF01586; Basic; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF12232; Myf5; 1.
DR   SMART; SM00520; BASIC; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..287
FT                   /note="Myoblast determination protein 1 homolog B"
FT                   /id="PRO_0000127371"
FT   DOMAIN          96..147
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          161..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          231..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   287 AA;  31896 MW;  B2A73231B8CB25A6 CRC64;
     MELLPPALRD MEETEGSLCA FPTPDHFYDD PCFNSSDMSF FEELEPRLVH VTLLKRGPRH
     EEEEEEHVRA PSGHHQAGRC LLWACKACKR KSSGADRRRA ATMRERRRLS KVNDAFETLK
     RCTSTNPNQR LPKVDILRNA ISYIDSLQTL LRDQEQSLYP NMEHYSGDSD ASSPSSNCSD
     GMNSPPCSSR RRNSYDSNFY TDSPNDVRLG KSSMISSLDC LSSIVERIST QSPSCPAPIS
     VDSGSEGSPC SPLQGETLSD RGIPISSPGN SCTQLSHDPS STIYQIL