MYOG_CHICK
ID MYOG_CHICK Reviewed; 227 AA.
AC P17920;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Myogenin;
DE AltName: Full=Myogenic factor;
GN Name=MYOG;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Pectoralis muscle;
RX PubMed=2168405; DOI=10.1016/s0021-9258(18)77244-x;
RA Fujisawa-Sehara A., Nabeshima Y., Hosoda Y., Obinata T., Nabeshima Y.;
RT "Myogenin contains two domains conserved among myogenic factors.";
RL J. Biol. Chem. 265:15219-15223(1990).
CC -!- FUNCTION: Acts as a transcriptional activator that promotes
CC transcription of muscle-specific target genes and plays a role in
CC muscle differentiation. Induces fibroblasts to differentiate into
CC myoblasts. Probable sequence specific DNA-binding protein (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer and heterodimer. Efficient DNA binding requires
CC dimerization with another bHLH protein (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; D90157; BAA14188.1; -; mRNA.
DR PIR; B35882; B35882.
DR RefSeq; NP_989515.1; NM_204184.1.
DR AlphaFoldDB; P17920; -.
DR SMR; P17920; -.
DR STRING; 9031.ENSGALP00000039912; -.
DR PaxDb; P17920; -.
DR Ensembl; ENSGALT00000040709; ENSGALP00000039912; ENSGALG00000000172.
DR GeneID; 374004; -.
DR KEGG; gga:374004; -.
DR CTD; 4656; -.
DR VEuPathDB; HostDB:geneid_374004; -.
DR eggNOG; KOG3960; Eukaryota.
DR GeneTree; ENSGT00950000182959; -.
DR HOGENOM; CLU_100258_0_0_1; -.
DR InParanoid; P17920; -.
DR OMA; PWACKIC; -.
DR OrthoDB; 1471470at2759; -.
DR PhylomeDB; P17920; -.
DR Reactome; R-GGA-525793; Myogenesis.
DR PRO; PR:P17920; -.
DR Proteomes; UP000000539; Chromosome 26.
DR Bgee; ENSGALG00000000172; Expressed in skeletal muscle tissue.
DR ExpressionAtlas; P17920; baseline and differential.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0032993; C:protein-DNA complex; ISS:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IDA:BHF-UCL.
DR GO; GO:0043425; F:bHLH transcription factor binding; IPI:BHF-UCL.
DR GO; GO:0031490; F:chromatin DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0070888; F:E-box binding; IDA:BHF-UCL.
DR GO; GO:0042802; F:identical protein binding; IPI:BHF-UCL.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0071392; P:cellular response to estradiol stimulus; ISS:UniProtKB.
DR GO; GO:0042693; P:muscle cell fate commitment; IDA:BHF-UCL.
DR GO; GO:0045445; P:myoblast differentiation; IMP:AgBase.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0014737; P:positive regulation of muscle atrophy; ISS:UniProtKB.
DR GO; GO:0045663; P:positive regulation of myoblast differentiation; ISS:UniProtKB.
DR GO; GO:0010831; P:positive regulation of myotube differentiation; ISS:UniProtKB.
DR GO; GO:0048743; P:positive regulation of skeletal muscle fiber development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:BHF-UCL.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:1901739; P:regulation of myoblast fusion; ISS:UniProtKB.
DR GO; GO:0014842; P:regulation of skeletal muscle satellite cell proliferation; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0014894; P:response to denervation involved in regulation of muscle adaptation; ISS:UniProtKB.
DR GO; GO:0014878; P:response to electrical stimulus involved in regulation of muscle adaptation; ISS:UniProtKB.
DR GO; GO:0014873; P:response to muscle activity involved in regulation of muscle adaptation; ISS:UniProtKB.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IBA:GO_Central.
DR GO; GO:0014891; P:striated muscle atrophy; ISS:UniProtKB.
DR GO; GO:0060290; P:transdifferentiation; IMP:AgBase.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR002546; MyoD_N.
DR InterPro; IPR039704; Myogenic_factor.
DR PANTHER; PTHR11534; PTHR11534; 1.
DR Pfam; PF01586; Basic; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00520; BASIC; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Myogenesis;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..227
FT /note="Myogenin"
FT /id="PRO_0000127379"
FT DOMAIN 82..133
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 147..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 163..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 227 AA; 25854 MW; 5E0466BFD672EE94 CRC64;
MELFETNPYF FPEQRFYDGE NFLGSRLQGY EAAAFPERPE VTLCPESRGA LEEKDSTLPE
HCPGQCLPWA CKICKRKTVS IDRRRAATLR EKRRLKKVNE AFEALKRSTL LNPNQRLPKV
EILRSAIQYI ERLQSLLSSL NQQEREQREL RYRPAAPQPA APSECGSGSS SCSPEWSTQL
EFGTNPADHL LSDDQAEDRN LHSLSSIVES IAVEDVAVTF PEERVQN
