MYOG_DICDI
ID MYOG_DICDI Reviewed; 3446 AA.
AC Q86AC8; Q551R1;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Myosin-G heavy chain;
GN Name=myoG; ORFNames=DDB_G0276363;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NOMENCLATURE.
RX PubMed=16857047; DOI=10.1186/1471-2164-7-183;
RA Kollmar M.;
RT "Thirteen is enough: the myosins of Dictyostelium discoideum and their
RT light chains.";
RL BMC Genomics 7:183-183(2006).
CC -!- FUNCTION: Myosins are actin-based motor molecules with ATPase activity.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000305}.
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DR EMBL; AAFI02000014; EAL69262.1; -; Genomic_DNA.
DR RefSeq; XP_643200.1; XM_638108.1.
DR SMR; Q86AC8; -.
DR STRING; 44689.DDB0232322; -.
DR PaxDb; Q86AC8; -.
DR PRIDE; Q86AC8; -.
DR EnsemblProtists; EAL69262; EAL69262; DDB_G0276363.
DR GeneID; 8620474; -.
DR KEGG; ddi:DDB_G0276363; -.
DR dictyBase; DDB_G0276363; myoG.
DR eggNOG; KOG4229; Eukaryota.
DR HOGENOM; CLU_224896_0_0_1; -.
DR InParanoid; Q86AC8; -.
DR OMA; SCHPYFI; -.
DR PRO; PR:Q86AC8; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0000146; F:microfilament motor activity; IBA:GO_Central.
DR GO; GO:0007015; P:actin filament organization; IBA:GO_Central.
DR GO; GO:0030041; P:actin filament polymerization; IMP:dictyBase.
DR GO; GO:0043327; P:chemotaxis to cAMP; IMP:dictyBase.
DR GO; GO:0030010; P:establishment of cell polarity; IMP:dictyBase.
DR GO; GO:0072657; P:protein localization to membrane; IMP:dictyBase.
DR GO; GO:0030587; P:sorocarp development; IMP:dictyBase.
DR GO; GO:0030050; P:vesicle transport along actin filament; IBA:GO_Central.
DR CDD; cd14473; FERM_B-lobe; 2.
DR Gene3D; 1.20.80.10; -; 2.
DR Gene3D; 1.25.40.530; -; 2.
DR Gene3D; 3.40.850.10; -; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR Pfam; PF00373; FERM_M; 2.
DR Pfam; PF00612; IQ; 2.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF00784; MyTH4; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00295; B41; 2.
DR SMART; SM00015; IQ; 2.
DR SMART; SM00242; MYSc; 1.
DR SMART; SM00139; MyTH4; 2.
DR SUPFAM; SSF47031; SSF47031; 2.
DR SUPFAM; SSF50044; SSF50044; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR SUPFAM; SSF54236; SSF54236; 2.
DR PROSITE; PS50057; FERM_3; 2.
DR PROSITE; PS50096; IQ; 2.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51016; MYTH4; 2.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Actin-binding; ATP-binding; Coiled coil; Motor protein; Myosin;
KW Nucleotide-binding; Reference proteome; Repeat; SH3 domain.
FT CHAIN 1..3446
FT /note="Myosin-G heavy chain"
FT /id="PRO_0000328605"
FT DOMAIN 439..1137
FT /note="Myosin motor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00782"
FT DOMAIN 1140..1169
FT /note="IQ 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1163..1192
FT /note="IQ 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00116"
FT DOMAIN 1868..2018
FT /note="MyTH4 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT DOMAIN 2023..2359
FT /note="FERM 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT DOMAIN 2707..2765
FT /note="SH3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00192"
FT DOMAIN 2945..3094
FT /note="MyTH4 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00359"
FT DOMAIN 3097..3173
FT /note="Ras-associating"
FT DOMAIN 3099..3409
FT /note="FERM 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00084"
FT REGION 1..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 216..254
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 266..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 981..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1030..1037
FT /note="Actin-binding"
FT /evidence="ECO:0000250"
FT REGION 1266..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1403..1481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1495..1565
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1604..1682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1828..1875
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2295..2314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2335..2618
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2839..2917
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3414..3446
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2782..2843
FT /evidence="ECO:0000255"
FT COILED 3402..3446
FT /evidence="ECO:0000255"
FT COMPBIAS 7..24
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..202
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..254
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1269..1336
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1348..1382
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2335..2513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2521..2618
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2839..2895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 531..538
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000250"
SQ SEQUENCE 3446 AA; 386918 MW; 7B76F3613C758087 CRC64;
MYNPWVDNPK DRDRTERDRS HSHSSSPNQQ HQSPNTISHR LSTAIPPINM AGTNIGGTPS
TSFDQISYLS PSTSNIPSTS PPLTRQIPSQ TTTPTVPPLS TSSLSSSTPI SSTNSTSSSK
LLSSNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNSN NNNNNNNNNN NNNNNNNNNN
NNNITVNSSS LSPHSKSNNS SGNLASLFEL ASIEESKKDK KNKKNKKHTN KQNSIGGSGN
TTPTSSSGNN TTSNNITITQ VITSNSNTLN NSNTLNNNNN NNNNNNNNNN NNNNNNNNSN
NNFSSIQGTN TNTNTNIISS SPSSPLTSMV SNSSNNNNNN NNNSTSQSNN GGVIGKTHQK
SIVPLLALPG QQQQNNNTSQ STSSSSSTSI SLPTNNQISC ERGPSSSRVH QSPSSSSSAS
SSSSNSLVHL MTLLEKNKVG FDDLSEIKDF EEDTLINIIQ ARYKKEIIYT YIGPILVSVN
PLRYLPFLHS QELVRNYNQR RGLPPHLFAL AAKAISDMQD FRRDQLIFIG GESGSGKSEN
TKIIIQYLLT TDLSRSKYLR DYILESGIIL ESFGHASTDS NHNSSRWGKY FEMFYSLYGE
IQGAKLYSYF LDENRVTYQN KGERNFHIFY QFLKGITDEE KAAYQLGDIN SYHYLNQGGS
ISVESIDDNR VFDRLKMSFV FFDFPSEKID LIFKTLSFII ILGNVTFFQK NGKTEVKDRT
LIESLSHNIT FDSTKLENIL ISDRSMPVNE AVENRDSLAR SLYSALFHWI IDFLNSKLKP
TQYSHTLGIL DLFGQESSQL NGYEQFSINF LEERLQQIYL QTVLKQEQRE YQTERIPWMT
PISFKDNEES VEMMEKIINL LDQESKNINS SDQIFLEKLQ NFLSRHHLFG KKPNKFGIEH
YFGQFYYDVR GFIIKNRDEI LQRTNVLHKN SITKYLFSRD GVFNINATVA ELNQMFDAKN
TAKKSPLSIV KVLLSCGSNN PNNVNNPNNN SGGGGGGGNS GGGSGSGGST YTTYSSTNKA
INNSNCDFHF IRCIKPNSKK THLTFDVKSV NEQIKSLCLL ETTRIQRFGY TIHYNNKIFF
DRFSFFFQNQ RNFQNLFEKL KENDINIDSI LPPPIQVGNT KIFLRYALGT LLESELQKRK
VRCAFTIQST WRMYLTRKRF IRMKSAIVII QKNTRRWLVQ KRYQSIKQAA LILESFSRMV
IFRAPYLRKR QAAIAIQTHL RSLLSKDYSY QCTLFLNTCT QDNATSSLPP IPQSLIIQIS
PPATPPASPL SFYSSQQSQL NNNNNSTPVN NNNNNNNNNN NNNNNNNNNN NNNNNNNINN
TTSTTTSNNT SQPPLSKKDR VVKFAQDYLN SSGGSASSPA LSPSDQSSES SPILSPSVSP
RNKEEITPRK YYSTFSSNSL NFNYNSLVNP RNDTTTTTQT NNTTTTTPTT PSTTTTTTTA
TTTTSSSSSS SSSSSSNNNI VSTPTSITNT PPTTGSKHGL NLPFNFITES AKSIKSTITG
APKSPRNSSE NSKSKVENTS TPVGFNLSST PNSAPSSAYS SPTINSNTTT TQQPNNNNNS
NNSVSSTAMA LTSISSSSTP NYNNSANNHQ RYSLNLNRRK SSHQLINNSN NNNNNNNINS
TNNEPLVSPG KNNQNNNNNN NNSNNSNNNN NNNNNNNNNN NNNTLTVPPS PRSPRGTQTK
ASPSFIYFPS TSPGVVNKVF SSSLTTPTGI SRAGTTTPSG SSKAGLLITT PGYTTSTQGG
IPQLPIYRPS YVNFLKKESL SSLSPKKRSK SILLNQQNDT EELSMLEYAK VNFELKSRKS
LIRKKQITFE SLVNYGKKLY YPLHKFGGDS NNDSNNNNNI NNNNSINNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNLDAS IVANLEKIAL DVFSHILQYM GDLERKKPHN QICTFIVRQG
LNHPELRDEI YCQIIKQLTG HPGKRENKAR GWELLSLCCG SFAPNSRLSK YVSNYLHSFK
QSRDDDGFAS ICLYRLDAIT QLGPRSLTPV DTEIEAVRKK VPLKVQFLFP DDVAEGVDID
SATTSGEITN RLTKLAGLKS DAFVWSVFEV LKNKERSVSN SEFILDIVSK WENYYFNLNH
YNLHVQQQSE QIPLEPFQFY FKIQLFLKPE KPPGEFEVGF YFHQLLRSVS KGHLPITDNE
VVKLSALRLQ FDILDNCTPK SPLEMWQRYI PQNYITTYSA KEWCDRVQTK YFEFLPYFNT
IQTKCKDIDS YKFEIRNIII AYLMSLPFYG CTIFYNCIQG VWTEIETGAM DGFNVIVDVN
GVHIVLKESI PGQNIIQPPQ QQSQQQSQQQ QSQQQQSQQQ QSQQQQSQQQ QSQQQSQQQQ
QQSQQNLVNA TPTKNITPRS NSSDQVVSPL TTSLDNNNNN NINVQDNNLT SIEETSTVNN
NNNNNSSLGS TGNVNETTNI DKTNTVSFDG DSSKNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNGEN KSNDTSSNSN GLSDSGKTNR LTIIVNENSQ KGDDNVVMLA
EPTPTPTSAF FNNINNQNNQ NNQNNNNQNI NNTPVSTPKV FSPVKKPVNT TNQVPSLPSI
SSNSNNSNSP STNTSATTNS TTNSTTTTTT TTTTTPLVES DIEPLSEFIF IEYLMDESNL
LLKSMGKPKK SFKTLKSFHY GKILNCETDA EQNIVTLSID HEDLLINTQQ STEMVLLINS
YIFHLSAEAT TGIANKDYSI PNSSFSFKVG NLITNIVRGE EDWCTGTCNN LTGKFPLELV
NLIIEKRSPN ILPSIPLNSK LYNRQQNNIT NLISTYDNIN NQLIINNNNI QQLLQQQQLQ
LQLQQQQQQQ QQQLLLQQQQ QQQSGNNSPS RKSSQAVQPS HRNSISRSTS SSSSASSNST
TSSSSSSSSS SGGKVKERKQ NNHNRGEPQF STKFVESGSK HPLMPYAVNR FRSLTAFKLG
DALKHSSNPP DSNSAFISDL HPDDRDIFLD IMKYMDDYPK FPRDRKTRLL QNVIQRGIDK
PSLRDEIYFF LCRQLTFNLQ TQLPTLASAR KGMVLFSLCS GCFPSTAELF PYLREFLSQT
ENIYSQYCIK KLETTSLKGP RRNAPSKKEI LAVKELRHIV VRIHLANGPI RTVEVNPSTT
ALEALRVLVD IQDIIFWKEF AIFKEWDGVE RALKEQDKLC DVLKEFEDKE RKQRKKLLPD
EDLITGRFVL LRKIWIPHTS YSMSNGMLEL MFYQYVHDVL GGRIPGLTIE ISLQLAALQL
QAQEGDYNPD TPIISEDTVY LCIPATLIGR KELSDWVQDI NEAHSLLANR DITPELALTS
YLEQSSGLPY AGSTWFCINT KRVATMATQI WIGINQGFIV FFNALMENEL ERFDLDEVSG
FTYRDDSFSF LIGDLINPTR KLFYTSQGED INEIFETFKS LPKVDLLELE RRKERKRERK
EKEKRKALKQ QLRDEQQQQL QQQQQD
