MYOM1_APLCA
ID MYOM1_APLCA Reviewed; 370 AA.
AC P15513; Q07974; Q27916;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 26-SEP-2001, sequence version 2.
DT 25-MAY-2022, entry version 70.
DE RecName: Full=Myomodulin neuropeptides 1;
DE Contains:
DE RecName: Full=Myomodulin-A;
DE Short=MM-A;
DE AltName: Full=Neuron B16 peptide;
DE AltName: Full=PMSMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-B;
DE Short=MM-B;
DE Short=MMb;
DE AltName: Full=GSYRMMRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-D;
DE Short=MM-D;
DE Short=MMd;
DE AltName: Full=GLSMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-F;
DE Short=MM-F;
DE Short=MMf;
DE AltName: Full=SLNMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-G;
DE Short=MM-G;
DE Short=MMg;
DE AltName: Full=TLSMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-H;
DE Short=MM-H;
DE Short=MMh;
DE AltName: Full=GLHMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-I;
DE Short=MM-I;
DE Short=MMi;
DE AltName: Full=SLSMLRL-amide;
DE Flags: Precursor;
GN Name=MYOMOD1;
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-362, AND TISSUE SPECIFICITY.
RC TISSUE=Abdominal ganglion, Cerebral ganglion, and CNS;
RX PubMed=8422272; DOI=10.1089/dna.1993.12.53;
RA Lopez V., Wickham L., Desgroseillers L.;
RT "Molecular cloning of myomodulin cDNA, a neuropeptide precursor gene
RT expressed in neuron L10 of Aplysia californica.";
RL DNA Cell Biol. 12:53-61(1993).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Buccal ganglion;
RX PubMed=8340812; DOI=10.1523/jneurosci.13-08-03358.1993;
RA Miller M.W., Beushausen S., Vitek A., Stamm S., Kupfermann I., Brosius J.,
RA Weiss K.R.;
RT "The myomodulin-related neuropeptides: characterization of a gene encoding
RT a family of peptide cotransmitters in Aplysia.";
RL J. Neurosci. 13:3358-3367(1993).
RN [3]
RP PROTEIN SEQUENCE OF 53-60, AMIDATION AT LEU-60, FUNCTION, AND TISSUE
RP SPECIFICITY.
RC TISSUE=Buccal muscle;
RX PubMed=1788132; DOI=10.1016/0196-9781(91)90120-e;
RA Cropper E.C., Vilim F.S., Alevizos A., Tenenbaum R., Kolks M.A.G.,
RA Rosen S., Kupfermann I., Weiss K.R.;
RT "Structure, bioactivity, and cellular localization of myomodulin B: a novel
RT Aplysia peptide.";
RL Peptides 12:683-690(1991).
RN [4]
RP PROTEIN SEQUENCE OF 63-69; 193-199; 203-209; 240-246 AND 358-364, AMIDATION
RP AT LEU-69; LEU-199; LEU-209; LEU-246 AND LEU-364, AND FUNCTION.
RC TISSUE=Buccal muscle;
RX PubMed=7472354; DOI=10.1152/jn.1995.74.1.54;
RA Brezina V., Bank B., Cropper E.C., Rosen S., Vilim F.S., Kupfermann I.,
RA Weiss K.R.;
RT "Nine members of the myomodulin family of peptide cotransmitters at the
RT B16-ARC neuromuscular junction of Aplysia.";
RL J. Neurophysiol. 74:54-72(1995).
RN [5]
RP PROTEIN SEQUENCE OF MYOMODULIN A, AMIDATION AT LEU-256; LEU-266; LEU-276;
RP LEU-286; LEU-296; LEU-306; LEU-316; LEU-326; LEU-336 AND LEU-346, AND
RP FUNCTION.
RC TISSUE=Buccal muscle;
RX PubMed=3474664; DOI=10.1073/pnas.84.15.5483;
RA Cropper E.C., Tenenbaum R., Kolks M.A.G., Kupfermann I., Weiss K.R.;
RT "Myomodulin: a bioactive neuropeptide present in an identified cholinergic
RT buccal motor neuron of Aplysia.";
RL Proc. Natl. Acad. Sci. U.S.A. 84:5483-5486(1987).
CC -!- FUNCTION: Exogenous application of myomodulins potentiates ARC muscle
CC contraction. {ECO:0000269|PubMed:1788132, ECO:0000269|PubMed:3474664,
CC ECO:0000269|PubMed:7472354}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in all ganglia of the CNS, but only in a
CC subset of neurons including L10 in the abdominal ganglion and B16 in
CC the buccal ganglion. {ECO:0000269|PubMed:1788132,
CC ECO:0000269|PubMed:8340812, ECO:0000269|PubMed:8422272}.
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DR EMBL; L01421; AAA27758.1; -; mRNA.
DR EMBL; S55210; AAB25131.1; -; mRNA.
DR EMBL; S55211; AAB25132.1; -; mRNA.
DR EMBL; S64300; AAB27697.1; -; mRNA.
DR PIR; A28340; A28340.
DR RefSeq; NP_001191423.1; NM_001204494.1.
DR AlphaFoldDB; P15513; -.
DR GeneID; 100533334; -.
DR CTD; 100533334; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Repeat; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..50
FT /evidence="ECO:0000255"
FT /id="PRO_0000001837"
FT PEPTIDE 53..60
FT /note="Myomodulin-B"
FT /evidence="ECO:0000269|PubMed:1788132"
FT /id="PRO_0000001838"
FT PEPTIDE 63..69
FT /note="Myomodulin-H"
FT /evidence="ECO:0000269|PubMed:7472354"
FT /id="PRO_0000001839"
FT PROPEP 73..190
FT /evidence="ECO:0000255"
FT /id="PRO_0000001840"
FT PEPTIDE 193..199
FT /note="Myomodulin-I"
FT /evidence="ECO:0000269|PubMed:7472354"
FT /id="PRO_0000001841"
FT PEPTIDE 203..209
FT /note="Myomodulin-D"
FT /evidence="ECO:0000269|PubMed:7472354"
FT /id="PRO_0000001842"
FT PROPEP 213..237
FT /evidence="ECO:0000255"
FT /id="PRO_0000001843"
FT PEPTIDE 240..246
FT /note="Myomodulin-G"
FT /evidence="ECO:0000269|PubMed:7472354"
FT /id="PRO_0000001844"
FT PEPTIDE 250..256
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001845"
FT PEPTIDE 260..266
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001846"
FT PEPTIDE 270..276
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001847"
FT PEPTIDE 280..286
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001848"
FT PEPTIDE 290..296
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001849"
FT PEPTIDE 300..306
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001850"
FT PEPTIDE 310..316
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001851"
FT PEPTIDE 320..326
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001852"
FT PEPTIDE 330..336
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001853"
FT PEPTIDE 340..346
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:3474664"
FT /id="PRO_0000001854"
FT PROPEP 350..355
FT /evidence="ECO:0000255"
FT /id="PRO_0000001855"
FT PEPTIDE 358..364
FT /note="Myomodulin-F"
FT /evidence="ECO:0000269|PubMed:7472354"
FT /id="PRO_0000001856"
FT PROPEP 368..370
FT /evidence="ECO:0000255"
FT /id="PRO_0000001857"
FT REGION 28..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 210..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 28..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 60
FT /note="Leucine amide"
FT MOD_RES 69
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:7472354"
FT MOD_RES 199
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:7472354"
FT MOD_RES 209
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:7472354"
FT MOD_RES 246
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:7472354"
FT MOD_RES 256
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 266
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 276
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 286
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 296
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 306
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 316
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 326
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 336
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 346
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:3474664"
FT MOD_RES 364
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:7472354"
FT VARIANT 362
FT /note="S -> L"
FT /evidence="ECO:0000269|PubMed:8422272"
FT CONFLICT 231
FT /note="D -> A (in Ref. 2; AAB27697)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 370 AA; 42254 MW; 3A792085939C88CB CRC64;
MQVYMLLPLA VFASLTYQGA CEETAAAQTS SDASTSSASS EHAENELSRA KRGSYRMMRL
GRGLHMLRLG KRGGPVEPES EENLETLLNL LQGYYSDVPE YPSEFDDTDL AYPYEEYDAP
AHPRYRRSTP PTDGVVAPDV LQKGSSEFED FGDSQLDESD EGYYGYDPEN YLYGDFEDYL
EPEEGGLGEE KRSLSMLRLG KRGLSMLRLG KREGEEGDEM DKKQDESLND DFENDDIKRT
LSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP
MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRP MSMLRLGKRD DDEKEKKSLN
MSRLGKRSTQ
