MYOM2_APLCA
ID MYOM2_APLCA Reviewed; 240 AA.
AC Q2VF17;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JAN-2006, sequence version 1.
DT 25-MAY-2022, entry version 29.
DE RecName: Full=Myomodulin neuropeptides 2;
DE Contains:
DE RecName: Full=Myomodulin-C;
DE Short=MM-C;
DE Short=MMc;
DE Contains:
DE RecName: Full=Myomodulin-E;
DE Short=MM-E;
DE Short=MMe;
DE Contains:
DE RecName: Full=MMG2-DPa;
DE Contains:
DE RecName: Full=MMG2-DPb;
DE Contains:
DE RecName: Full=MMG2-DPd;
DE Contains:
DE RecName: Full=MMG2-DPf;
DE Flags: Precursor;
GN Name=MMG2;
OS Aplysia californica (California sea hare).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Tectipleura; Aplysiida; Aplysioidea;
OC Aplysiidae; Aplysia.
OX NCBI_TaxID=6500;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEOLYTIC PROCESSING, SUBCELLULAR
RP LOCATION, PYROGLUTAMATE FORMATION AT GLN-115, AMIDATION AT LEU-51; LEU-60;
RP ALA-81; TYR-121; ILE-207 AND ILE-226, AND MASS SPECTROMETRY.
RX PubMed=16237168; DOI=10.1523/jneurosci.2932-05.2005;
RA Proekt A., Vilim F.S., Alexeeva V., Brezina V., Friedman A., Jing J.,
RA Li L., Zhurov Y., Sweedler J.V., Weiss K.R.;
RT "Identification of a new neuropeptide precursor reveals a novel source of
RT extrinsic modulation in the feeding system of Aplysia.";
RL J. Neurosci. 25:9637-9648(2005).
RN [2]
RP MASS SPECTROMETRY.
RX PubMed=9809658; DOI=10.1016/s0196-9781(98)00094-1;
RA Li L., Moroz T.P., Garden R.W., Floyd P.D., Weiss K.R., Sweedler J.V.;
RT "Mass spectrometric survey of interganglionically transported peptides in
RT Aplysia.";
RL Peptides 19:1425-1433(1998).
CC -!- FUNCTION: MMG2-DPs (Myomodulin gene 2-derived peptides) bias egestive
CC feeding programs toward ingestive ones, and modulate accessory radula
CC closer (ARC) muscle contractions. {ECO:0000269|PubMed:16237168}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16237168}.
CC -!- TISSUE SPECIFICITY: Expressed in the pedal-buccal projection neurons in
CC the pedal ganglion.
CC -!- MASS SPECTROMETRY: [Myomodulin-C]: Mass=860.7; Mass_error=0.2;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:9809658};
CC -!- MASS SPECTROMETRY: [Myomodulin-E]: Mass=828.7; Mass_error=0.2;
CC Method=MALDI; Evidence={ECO:0000269|PubMed:9809658};
CC -!- MASS SPECTROMETRY: [MMG2-DPa]: Mass=1862.97; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16237168};
CC -!- MASS SPECTROMETRY: [MMG2-DPb]: Mass=851.45; Method=MALDI; Note=MMG2-DPb
CC without pyrrolidone carboxylic acid.;
CC Evidence={ECO:0000269|PubMed:16237168};
CC -!- MASS SPECTROMETRY: [MMG2-DPb]: Mass=868.48; Method=MALDI; Note=MMG2-DPb
CC with pyrrolidone carboxylic acid.;
CC Evidence={ECO:0000269|PubMed:16237168};
CC -!- MASS SPECTROMETRY: [MMG2-DPd]: Mass=737.48; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16237168};
CC -!- MASS SPECTROMETRY: [MMG2-DPf]: Mass=806.51; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:16237168};
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DR EMBL; DQ186993; ABA70768.1; -; mRNA.
DR RefSeq; NP_001191658.1; NM_001204729.1.
DR AlphaFoldDB; Q2VF17; -.
DR GeneID; 100533452; -.
DR OrthoDB; 1652054at2759; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide;
KW Pyrrolidone carboxylic acid; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..44
FT /id="PRO_0000343847"
FT PEPTIDE 45..51
FT /note="Myomodulin-C"
FT /id="PRO_0000343848"
FT PEPTIDE 54..60
FT /note="Myomodulin-E"
FT /id="PRO_0000343849"
FT PEPTIDE 64..81
FT /note="MMG2-DPa"
FT /id="PRO_0000343850"
FT PROPEP 72..81
FT /note="Connecting peptide"
FT /id="PRO_0000343851"
FT PROPEP 84..112
FT /note="Connecting peptide"
FT /id="PRO_0000343852"
FT PEPTIDE 115..121
FT /note="MMG2-DPb"
FT /id="PRO_0000343853"
FT PROPEP 124..168
FT /note="Connecting peptide"
FT /id="PRO_0000343854"
FT PROPEP 124..149
FT /note="Connecting peptide"
FT /id="PRO_0000343855"
FT PROPEP 124..148
FT /note="Connecting peptide"
FT /id="PRO_0000343856"
FT PROPEP 124..147
FT /note="Connecting peptide"
FT /id="PRO_0000343857"
FT PROPEP 131..168
FT /note="Connecting peptide"
FT /id="PRO_0000343858"
FT PROPEP 149..168
FT /note="Connecting peptide"
FT /id="PRO_0000343859"
FT PROPEP 150..168
FT /note="Connecting peptide"
FT /id="PRO_0000343860"
FT PROPEP 151..168
FT /note="Connecting peptide"
FT /id="PRO_0000343861"
FT PROPEP 171..199
FT /note="Connecting peptide"
FT /id="PRO_0000343862"
FT PROPEP 171..190
FT /note="Connecting peptide"
FT /id="PRO_0000343863"
FT PEPTIDE 201..207
FT /note="MMG2-DPd"
FT /id="PRO_0000343864"
FT PROPEP 210..219
FT /id="PRO_0000343865"
FT PEPTIDE 220..226
FT /note="MMG2-DPf"
FT /id="PRO_0000343866"
FT PROPEP 227..240
FT /id="PRO_0000343867"
FT REGION 23..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..44
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 51
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 60
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 81
FT /note="Alanine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 115
FT /note="Pyrrolidone carboxylic acid"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 121
FT /note="Tyrosine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 207
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
FT MOD_RES 226
FT /note="Isoleucine amide"
FT /evidence="ECO:0000269|PubMed:16237168"
SQ SEQUENCE 240 AA; 26120 MW; 170D35C34C43C50E CRC64;
MWKILETCSC FLVVAVLSGL GKAQPESFSG SAVTDDSTSG ANKRGWSMLR LGRGLQMLRL
GKRGGSLDAL RSGHQVPMLR AGRGSPDTSG RLDANELYAV LSAILDEPRD QSRRQPPLPR
YGRDNNGVAR DLLDALASDG ESSSNFDLLS SLNNGPSYFR PAPRGGRYKR SLPDAGPADY
PSLEDYLVQS RQFARPYSSR AVALPRIGRF SGSPRLQAKA VPRPRIGRQE SQMREAKSAE
