MYOM3_HUMAN
ID MYOM3_HUMAN Reviewed; 1437 AA.
AC Q5VTT5; A6NF75; Q5VTT6; Q6AWC0; Q6AWC1; Q6NXF9; Q6ZRG7; Q7Z3G9; Q8NA11;
AC Q96C54;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Myomesin-3;
DE AltName: Full=Myomesin family member 3;
GN Name=MYOM3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 266-1437 (ISOFORM 1), AND VARIANTS MET-266; THR-344;
RP ARG-435; GLY-528 AND ARG-662.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS GLY-528
RP AND GLN-1124.
RC TISSUE=Brain, and Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1401 (ISOFORM 1), AND VARIANTS
RP HIS-258; MET-266; THR-344; GLY-528; ARG-662 AND SER-853.
RC TISSUE=Skeletal muscle;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May link the intermediate filament cytoskeleton to the M-disk
CC of the myofibrils in striated muscle. {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5VTT5-2; Q9BSK4: FEM1A; NbExp=3; IntAct=EBI-12247808, EBI-2515349;
CC Q5VTT5-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-12247808, EBI-618309;
CC Q5VTT5-2; Q9H8Y8: GORASP2; NbExp=3; IntAct=EBI-12247808, EBI-739467;
CC Q5VTT5-2; Q13287: NMI; NbExp=6; IntAct=EBI-12247808, EBI-372942;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5VTT5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VTT5-2; Sequence=VSP_030544, VSP_030545;
CC Name=3;
CC IsoId=Q5VTT5-3; Sequence=VSP_030542, VSP_030543;
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DR EMBL; AK093280; BAC04119.1; -; mRNA.
DR EMBL; AK128233; BAC87343.1; -; mRNA.
DR EMBL; AL591178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471134; EAW95108.1; -; Genomic_DNA.
DR EMBL; BC014671; AAH14671.1; -; mRNA.
DR EMBL; BC067101; AAH67101.1; -; mRNA.
DR EMBL; BX537911; CAD97895.1; -; mRNA.
DR EMBL; BX647453; CAH10377.1; -; mRNA.
DR EMBL; BX647455; CAH10376.1; -; mRNA.
DR CCDS; CCDS41281.1; -. [Q5VTT5-1]
DR RefSeq; NP_689585.3; NM_152372.3. [Q5VTT5-1]
DR AlphaFoldDB; Q5VTT5; -.
DR SMR; Q5VTT5; -.
DR BioGRID; 126050; 8.
DR IntAct; Q5VTT5; 7.
DR STRING; 9606.ENSP00000363557; -.
DR GlyGen; Q5VTT5; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q5VTT5; -.
DR PhosphoSitePlus; Q5VTT5; -.
DR BioMuta; MYOM3; -.
DR DMDM; 74762257; -.
DR MassIVE; Q5VTT5; -.
DR PaxDb; Q5VTT5; -.
DR PeptideAtlas; Q5VTT5; -.
DR PRIDE; Q5VTT5; -.
DR ProteomicsDB; 65352; -. [Q5VTT5-1]
DR ProteomicsDB; 65353; -. [Q5VTT5-2]
DR ProteomicsDB; 65354; -. [Q5VTT5-3]
DR Antibodypedia; 30256; 67 antibodies from 20 providers.
DR DNASU; 127294; -.
DR Ensembl; ENST00000338909.9; ENSP00000342689.5; ENSG00000142661.19. [Q5VTT5-3]
DR Ensembl; ENST00000374434.4; ENSP00000363557.3; ENSG00000142661.19. [Q5VTT5-1]
DR GeneID; 127294; -.
DR KEGG; hsa:127294; -.
DR MANE-Select; ENST00000374434.4; ENSP00000363557.3; NM_152372.4; NP_689585.3.
DR UCSC; uc001bil.5; human. [Q5VTT5-1]
DR CTD; 127294; -.
DR DisGeNET; 127294; -.
DR GeneCards; MYOM3; -.
DR HGNC; HGNC:26679; MYOM3.
DR HPA; ENSG00000142661; Group enriched (heart muscle, skeletal muscle, tongue).
DR neXtProt; NX_Q5VTT5; -.
DR OpenTargets; ENSG00000142661; -.
DR PharmGKB; PA134899390; -.
DR VEuPathDB; HostDB:ENSG00000142661; -.
DR eggNOG; ENOG502RDUJ; Eukaryota.
DR GeneTree; ENSGT00940000158669; -.
DR HOGENOM; CLU_854026_0_0_1; -.
DR InParanoid; Q5VTT5; -.
DR OMA; YYVERCD; -.
DR OrthoDB; 57219at2759; -.
DR PhylomeDB; Q5VTT5; -.
DR TreeFam; TF331825; -.
DR PathwayCommons; Q5VTT5; -.
DR SignaLink; Q5VTT5; -.
DR BioGRID-ORCS; 127294; 10 hits in 1067 CRISPR screens.
DR GenomeRNAi; 127294; -.
DR Pharos; Q5VTT5; Tbio.
DR PRO; PR:Q5VTT5; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5VTT5; protein.
DR Bgee; ENSG00000142661; Expressed in apex of heart and 131 other tissues.
DR Genevisible; Q5VTT5; HS.
DR GO; GO:0031430; C:M band; ISS:UniProtKB.
DR GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR GO; GO:0006936; P:muscle contraction; IBA:GO_Central.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; -; 12.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF00047; ig; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 3.
DR SUPFAM; SSF48726; SSF48726; 6.
DR SUPFAM; SSF49265; SSF49265; 3.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Immunoglobulin domain;
KW Reference proteome; Repeat.
FT CHAIN 1..1437
FT /note="Myomesin-3"
FT /id="PRO_0000315394"
FT DOMAIN 154..246
FT /note="Ig-like C2-type 1"
FT DOMAIN 269..361
FT /note="Ig-like C2-type 2"
FT DOMAIN 375..469
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 503..598
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 604..696
FT /note="Fibronectin type-III 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 702..797
FT /note="Fibronectin type-III 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 804..899
FT /note="Fibronectin type-III 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 1120..1205
FT /note="Ig-like C2-type 3"
FT DOMAIN 1334..1423
FT /note="Ig-like C2-type 4"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 120..149
FT /evidence="ECO:0000255"
FT COMPBIAS 18..49
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1107
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030542"
FT VAR_SEQ 1108..1141
FT /note="DAKRRDWKRKQGPYFERPLQWKVTEDCQVQLTCK -> MDISKKNRVRQGSR
FT GRGKTISKNSESRGQQRRHM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030543"
FT VAR_SEQ 1179..1212
FT /note="LSKKDKGIYRAMVSDDRGEDDTILDLTGDALDAI -> ASVAPASGLTFSFG
FT CKPGRAKSSGLGVRAGPRLG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030544"
FT VAR_SEQ 1213..1437
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030545"
FT VARIANT 258
FT /note="D -> H (in dbSNP:rs4319261)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_049910"
FT VARIANT 266
FT /note="T -> M (in dbSNP:rs6678540)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_038179"
FT VARIANT 344
FT /note="M -> T (in dbSNP:rs4233050)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_038180"
FT VARIANT 435
FT /note="Q -> R (in dbSNP:rs6700245)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_038181"
FT VARIANT 528
FT /note="D -> G (in dbSNP:rs4393101)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005"
FT /id="VAR_038182"
FT VARIANT 662
FT /note="G -> R (in dbSNP:rs4320729)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_038183"
FT VARIANT 775
FT /note="R -> Q (in dbSNP:rs12082295)"
FT /id="VAR_038184"
FT VARIANT 853
FT /note="P -> S (in dbSNP:rs35446243)"
FT /evidence="ECO:0000269|PubMed:17974005"
FT /id="VAR_038185"
FT VARIANT 892
FT /note="D -> A (in dbSNP:rs36077733)"
FT /id="VAR_038186"
FT VARIANT 1041
FT /note="F -> L (in dbSNP:rs16829083)"
FT /id="VAR_038187"
FT VARIANT 1066
FT /note="I -> T (in dbSNP:rs12145360)"
FT /id="VAR_038188"
FT VARIANT 1124
FT /note="R -> Q (in dbSNP:rs16829071)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_038189"
FT CONFLICT 1083
FT /note="Q -> R (in Ref. 1; BAC87343)"
FT /evidence="ECO:0000305"
FT CONFLICT 1246
FT /note="N -> D (in Ref. 5; CAH10376)"
FT /evidence="ECO:0000305"
FT CONFLICT 1344
FT /note="A -> T (in Ref. 5; CAH10376)"
FT /evidence="ECO:0000305"
FT CONFLICT 1350
FT /note="K -> R (in Ref. 1; BAC04119)"
FT /evidence="ECO:0000305"
FT CONFLICT 1414
FT /note="G -> V (in Ref. 1; BAC04119)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1437 AA; 162189 MW; 0025DEF2965AA001 CRC64;
MTLPHSLGGA GDPRPPQAME VHRLEHRQEE EQKEERQHSL RMGSSVRRRT FRSSEEEHEF
SAADYALAAA LALTASSELS WEAQLRRQTS AVELEERGQK RVGFGNDWER TEIAFLQTHR
LLRQRRDWKT LRRRTEEKVQ EAKELRELCY GRGPWFWIPL RSHAVWEHTT VLLTCTVQAS
PPPQVTWYKN DTRIDPRLFR AGKYRITNNY GLLSLEIRRC AIEDSATYTV RVKNAHGQAS
SFAKVLVRTY LGKDAGFDSE IFKRSTFGPS VEFTSVLKPV FAREKEPFSL SCLFSEDVLD
AESIQWFRDG SLLRSSRRRK ILYTDRQASL KVSCTYKEDE GLYMVRVPSP FGPREQSTYV
LVRDAEAENP GAPGSPLNVR CLDVNRDCLI LTWAPPSDTR GNPITAYTIE RCQGESGEWI
ACHEAPGGTC RCPIQGLVEG QSYRFRVRAI SRVGSSVPSK ASELVVMGDH DAARRKTEIP
FDLGNKITIS TDAFEDTVTI PSPPTNVHAS EIREAYVVLA WEEPSPRDRA PLTYSLEKSV
IGSGTWEAIS SESPVRSPRF AVLDLEKKKS YVFRVRAMNQ YGLSDPSEPS EPIALRGPPA
TLPPPAQVQA FRDTQTSVSL TWDPVKDPEL LGYYIYSRKV GTSEWQTVNN KPIQGTRFTV
PGLRTGKEYE FCVRSVSEAG VGESSAATEP IRVKQALATP SAPYGFALLN CGKNEMVIGW
KPPKRRGGGK ILGYFLDQHD SEELDWHAVN QQPIPTRVCK VSDLHEGHFY EFRARAANWA
GVGELSAPSS LFECKEWTMP QPGPPYDVRA SEVRATSLVL QWEPPLYMGA GPVTGYHVSF
QEEGSEQWKP VTPGPISGTH LRVSDLQPGK SYVFQVQAMN SAGLGQPSMP TDPVLLEDKP
GAHEIEVGVD EEGFIYLAFE APEAPDSSEF QWSKDYKGPL DPQRVKIEDK VNKSKVILKE
PGLEDLGTYS VIVTDADEDI SASHTLTEEE LEKLKKLSHE IRNPVIKLIS GWNIDILERG
EVRLWLEVEK LSPAAELHLI FNNKEIFSSP NRKINFDREK GLVEVIIQNL SEEDKGSYTA
QLQDGKAKNQ ITLTLVDDDF DKLLRKADAK RRDWKRKQGP YFERPLQWKV TEDCQVQLTC
KVTNTKKETR FQWFFQRAEM PDGQYDPETG TGLLCIEELS KKDKGIYRAM VSDDRGEDDT
ILDLTGDALD AIFTELGRIG ALSATPLKIQ GTEEGIRIFS KVKYYNVEYM KTTWFHKDKR
LESGDRIRTG TTLDEIWLHI LDPKDSDKGK YTLEIAAGKE VRQLSTDLSG QAFEDAMAEH
QRLKTLAIIE KNRAKVVRGL PDVATIMEDK TLCLTCIVSG DPTPEISWLK NDQPVTFLDR
YRMEVRGTEV TITIEKVNSE DSGRYGVFVK NKYGSETGQV TISVFKHGDE PKELKSM
