MYOM_LYMST
ID MYOM_LYMST Reviewed; 350 AA.
AC Q25413; Q25406;
DT 26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 54.
DE RecName: Full=Myomodulin neuropeptides;
DE Contains:
DE RecName: Full=GLQMLRL-amide;
DE Contains:
DE RecName: Full=QIPMLRL-amide;
DE Contains:
DE RecName: Full=SMSMLRL-amide;
DE Contains:
DE RecName: Full=SLSMLRL-amide;
DE Contains:
DE RecName: Full=Myomodulin-A;
DE AltName: Full=PMSMLRL-amide;
DE Flags: Precursor;
OS Lymnaea stagnalis (Great pond snail) (Helix stagnalis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Heterobranchia; Euthyneura; Panpulmonata; Hygrophila; Lymnaeoidea;
OC Lymnaeidae; Lymnaea.
OX NCBI_TaxID=6523;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, AND AMIDATION
RP AT LEU-61; LEU-187; LEU-197; LEU-219; LEU-245; LEU-255; LEU-265; LEU-275;
RP LEU-285; LEU-295; LEU-305; LEU-315; LEU-325 AND LEU-335.
RC TISSUE=CNS;
RX PubMed=8756426; DOI=10.1523/jneurosci.16-16-04949.1996;
RA Kellett E., Perry S.J., Santama N., Worster B.M., Benjamin P.R.,
RA Burke J.F.;
RT "Myomodulin gene of Lymnaea: structure, expression, and analysis of
RT neuropeptides.";
RL J. Neurosci. 16:4949-4957(1996).
RN [2]
RP PROTEIN SEQUENCE OF MYOMODULIN, FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Pedal ganglion, and Penis;
RX PubMed=7808235; DOI=10.1016/0169-328x(94)90172-4;
RA Li K.W., van Golen F.A., van Minnen J., van Veelen P.A., van der Greef J.,
RA Geraerts W.P.M.;
RT "Structural identification, neuronal synthesis, and role in male copulation
RT of myomodulin-A of Lymnaea: a study involving direct peptide profiling of
RT nervous tissue by mass spectrometry.";
RL Brain Res. Mol. Brain Res. 25:355-358(1994).
RN [3]
RP PARTIAL PROTEIN SEQUENCE, FUNCTION, MASS SPECTROMETRY, AND AMIDATION AT
RP LEU-61; LEU-197; LEU-219; LEU-245; LEU-255; LEU-265; LEU-275; LEU-285;
RP LEU-295; LEU-305; LEU-315; LEU-325 AND LEU-335.
RC TISSUE=Penis;
RX PubMed=8522970; DOI=10.1046/j.1471-4159.1996.66010321.x;
RA van Golen F.A., Li K.W., Chen S., Jimenez C.R., Geraerts W.P.M.;
RT "Various isoforms of myomodulin identified from the male copulatory organ
RT of Lymnaea show overlapping yet distinct modulatory effects on the penis
RT muscle.";
RL J. Neurochem. 66:321-329(1996).
CC -!- FUNCTION: Myomodulins enhance the relaxation rate of electrically-
CC induced contraction of the penis retractor muscle.
CC {ECO:0000269|PubMed:7808235, ECO:0000269|PubMed:8522970}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in all ganglia of the CNS, but only in a
CC subset of neurons. {ECO:0000269|PubMed:7808235,
CC ECO:0000269|PubMed:8756426}.
CC -!- MASS SPECTROMETRY: [GLQMLRL-amide]: Mass=829.1; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:8522970};
CC -!- MASS SPECTROMETRY: [SMSMLRL-amide]: Mass=836.3; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:8522970};
CC -!- MASS SPECTROMETRY: [SLSMLRL-amide]: Mass=817.8; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:8522970};
CC -!- MASS SPECTROMETRY: [Myomodulin-A]: Mass=846.4; Method=Unknown;
CC Evidence={ECO:0000269|PubMed:8522970};
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DR EMBL; X96933; CAA65635.1; -; mRNA.
DR EMBL; X96934; CAA65636.1; -; Genomic_DNA.
DR AlphaFoldDB; Q25413; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..53
FT /evidence="ECO:0000255"
FT /id="PRO_0000001858"
FT PEPTIDE 55..61
FT /note="GLQMLRL-amide"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001859"
FT PROPEP 65..178
FT /evidence="ECO:0000255"
FT /id="PRO_0000001860"
FT PEPTIDE 181..187
FT /note="QIPMLRL-amide"
FT /evidence="ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001861"
FT PEPTIDE 191..197
FT /note="SMSMLRL-amide"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001862"
FT PROPEP 201..210
FT /evidence="ECO:0000255"
FT /id="PRO_0000001863"
FT PEPTIDE 213..219
FT /note="SLSMLRL-amide"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001864"
FT PROPEP 223..236
FT /evidence="ECO:0000255"
FT /id="PRO_0000001865"
FT PEPTIDE 239..245
FT /note="SLSMLRL-amide"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001866"
FT PEPTIDE 249..255
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001867"
FT PEPTIDE 259..265
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001868"
FT PEPTIDE 269..275
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001869"
FT PEPTIDE 279..285
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001870"
FT PEPTIDE 289..295
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001871"
FT PEPTIDE 299..305
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001872"
FT PEPTIDE 309..315
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001873"
FT PEPTIDE 319..325
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001874"
FT PEPTIDE 329..335
FT /note="Myomodulin-A"
FT /evidence="ECO:0000269|PubMed:7808235,
FT ECO:0000269|PubMed:8756426"
FT /id="PRO_0000001875"
FT PROPEP 339..350
FT /evidence="ECO:0000255"
FT /id="PRO_0000001876"
FT REGION 22..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 115..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 22..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 61
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 187
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8756426"
FT MOD_RES 197
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 219
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 245
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 255
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 265
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 275
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 285
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 295
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 305
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 315
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 325
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
FT MOD_RES 335
FT /note="Leucine amide"
FT /evidence="ECO:0000269|PubMed:8522970,
FT ECO:0000269|PubMed:8756426"
SQ SEQUENCE 350 AA; 40388 MW; 02A6D1931B2EDD6D CRC64;
MQGAFLITFI VLTMTLVSIG NTEESGGQTS SNDKTEPAQS RTKRRSREMG RVVRGLQMLR
LGKRDSVSTS EDPGDIDDIL SLLQAYQEQN PEFAFNEEER ELSGDELEVP EHHRFRRSTE
NSGVAPQEVQ QSQSFKDSGE HELKLEEAEP YLYFPDGDFY YGDVDELLEG DNEDGSADKR
QIPMLRLGKR SMSMLRLGKR EEDDADFDEE KRSLSMLRLG KREDDNFEDS FDEENDKRSL
SMLRLGKRPM SMLRLGKRPM SMLRLGKRPM SMLRLGKRPM SMLRLGKRPM SMLRLGKRPM
SMLRLGKRPM SMLRLGKRPM SMLRLGKRPM SMLRLGKRED DEEKRSLAMS
