ID   MYOZ1_BOVIN             Reviewed;         297 AA.
AC   Q8SQ24;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Myozenin-1;
DE   AltName: Full=Calsarcin-2;
GN   Name=MYOZ1; Synonyms=MYOZ;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Takada F., Beggs A.H.;
RL   Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC       involved in linking Z-disk proteins such as alpha-actinin, gamma-
CC       filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC       signaling to the sarcomere. Plays an important role in the modulation
CC       of calcineurin signaling. May play a role in myofibrillogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA
CC       and TCAP. Interacts via its C-terminal region with MYOT (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell projection,
CC       pseudopodium {ECO:0000250}. Note=Localized to the nucleus and
CC       pseudopodia of undifferentiated cells and detected throughout the
CC       myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT
CC       at the Z-lines of skeletal muscle (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR   EMBL; AF359567; AAM00243.1; -; mRNA.
DR   RefSeq; NP_776822.1; NM_174397.2.
DR   RefSeq; XP_015316475.1; XM_015460989.1.
DR   AlphaFoldDB; Q8SQ24; -.
DR   SMR; Q8SQ24; -.
DR   STRING; 9913.ENSBTAP00000051138; -.
DR   PRIDE; Q8SQ24; -.
DR   Ensembl; ENSBTAT00000028159; ENSBTAP00000028159; ENSBTAG00000033008.
DR   GeneID; 281939; -.
DR   KEGG; bta:281939; -.
DR   CTD; 58529; -.
DR   VEuPathDB; HostDB:ENSBTAG00000033008; -.
DR   VGNC; VGNC:31840; MYOZ1.
DR   eggNOG; ENOG502R4N9; Eukaryota.
DR   GeneTree; ENSGT00950000183027; -.
DR   InParanoid; Q8SQ24; -.
DR   OrthoDB; 988464at2759; -.
DR   Proteomes; UP000009136; Chromosome 28.
DR   Bgee; ENSBTAG00000033008; Expressed in biceps femoris and 102 other tissues.
DR   ExpressionAtlas; Q8SQ24; baseline and differential.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR   GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR   InterPro; IPR008438; MYOZ.
DR   PANTHER; PTHR15941; PTHR15941; 1.
DR   Pfam; PF05556; Calsarcin; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..297
FT                   /note="Myozenin-1"
FT                   /id="PRO_0000111094"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK37"
SQ   SEQUENCE   297 AA;  31674 MW;  11D09662F65E092A CRC64;
     MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF
     KLRQLRVEKF IYENHPDVFS DSSMDRFQKF IPTVGGQLGT AGQGFSYSKS SGGGQAGRSG
     SAGQYGSDQQ HHHQGSGSGS GSGSGPGSGG AGGPGGHSGR GGALPDNQAG GEGKHITVFK
     TYISPWEKAM GIDPQQKVEL GIDLLAYGAK AELPKYKSFN RTAMPYGGYE KASKRMTFQM
     PKFDLGPLLS EPLVLYNQNL SNRPSFNRTP IPWLSSGEPV DYNVDISIPL DGETEEL