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MYOZ1_PIG
ID   MYOZ1_PIG               Reviewed;         298 AA.
AC   Q4PS85; Q1AG04;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Myozenin-1;
DE   AltName: Full=Calcineurin-interacting protein 2;
DE   AltName: Full=Calsarcin-2;
GN   Name=MYOZ1;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX   PubMed=16574346; DOI=10.1016/j.gene.2006.01.035;
RA   Wang H., Zhu Z., Wang H., Yang S., Mo D., Li K.;
RT   "Characterization of different expression patterns of calsarcin-1 and
RT   calsarcin-2 in porcine muscle.";
RL   Gene 374C:104-111(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Su Y., Liu D., Song H., Zeng R., Kong D., Zhu B., Ba C.;
RT   "Cloning and sequencing of calsarcin-2 (myoz1) in skeletal muscle of
RT   pigs.";
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC       involved in linking Z-disk proteins such as alpha-actinin, gamma-
CC       filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC       signaling to the sarcomere. Plays an important role in the modulation
CC       of calcineurin signaling. May play a role in myofibrillogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA
CC       and TCAP. Interacts via its C-terminal region with MYOT (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell projection,
CC       pseudopodium {ECO:0000250}. Note=Localized to the nucleus and
CC       pseudopodia of undifferentiated cells and detected throughout the
CC       myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT
CC       at the Z-lines of skeletal muscle (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR   EMBL; DQ143040; ABA12602.1; -; mRNA.
DR   EMBL; DQ143042; ABA12604.1; -; Genomic_DNA.
DR   EMBL; DQ058294; AAY78933.1; -; mRNA.
DR   RefSeq; NP_001020393.1; NM_001025222.2.
DR   RefSeq; XP_005671146.1; XM_005671089.2.
DR   AlphaFoldDB; Q4PS85; -.
DR   PaxDb; Q4PS85; -.
DR   PeptideAtlas; Q4PS85; -.
DR   PRIDE; Q4PS85; -.
DR   Ensembl; ENSSSCT00005023091; ENSSSCP00005013839; ENSSSCG00005014773.
DR   Ensembl; ENSSSCT00015107000; ENSSSCP00015045121; ENSSSCG00015078943.
DR   Ensembl; ENSSSCT00025045717; ENSSSCP00025019502; ENSSSCG00025033590.
DR   Ensembl; ENSSSCT00030104559; ENSSSCP00030048511; ENSSSCG00030074487.
DR   Ensembl; ENSSSCT00035097705; ENSSSCP00035041237; ENSSSCG00035072203.
DR   Ensembl; ENSSSCT00040005665; ENSSSCP00040002149; ENSSSCG00040004299.
DR   Ensembl; ENSSSCT00045019062; ENSSSCP00045013083; ENSSSCG00045011230.
DR   Ensembl; ENSSSCT00050055000; ENSSSCP00050023260; ENSSSCG00050040637.
DR   Ensembl; ENSSSCT00055053130; ENSSSCP00055042397; ENSSSCG00055026866.
DR   Ensembl; ENSSSCT00060101147; ENSSSCP00060043941; ENSSSCG00060073956.
DR   Ensembl; ENSSSCT00065007083; ENSSSCP00065003059; ENSSSCG00065005213.
DR   Ensembl; ENSSSCT00070010852; ENSSSCP00070008935; ENSSSCG00070005711.
DR   GeneID; 574060; -.
DR   KEGG; ssc:574060; -.
DR   CTD; 58529; -.
DR   eggNOG; ENOG502R4N9; Eukaryota.
DR   HOGENOM; CLU_071316_0_0_1; -.
DR   InParanoid; Q4PS85; -.
DR   TreeFam; TF331748; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Chromosome 14.
DR   Genevisible; Q4PS85; SS.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR   GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IEA:Ensembl.
DR   GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0043417; P:negative regulation of skeletal muscle tissue regeneration; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR   GO; GO:0043503; P:skeletal muscle fiber adaptation; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR   InterPro; IPR008438; MYOZ.
DR   PANTHER; PTHR15941; PTHR15941; 1.
DR   Pfam; PF05556; Calsarcin; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..298
FT                   /note="Myozenin-1"
FT                   /id="PRO_0000111097"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          105..173
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         82
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JK37"
SQ   SEQUENCE   298 AA;  31667 MW;  83F677DB661C0190 CRC64;
     MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF
     KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT AGQGFSYSKG SSGGQAGGSS
     SAGQYGSGQQ HHHQGSGSGS GGAGGPGSQT GRGGDAGTTG VGETGTGDQA GGEGKHITVF
     KTYISPWEKA MGVDPHQKVE LGIDLLAYGA KAELPQYKSF NRTAMPYGGY EKASKRMTFQ
     MPKFDLGPLL SEPLVLYNQN LSNRPSFNRT PIPWLSSGEP VDYNVDIGIP LDGETEEL
 
 
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