MYOZ1_PIG
ID MYOZ1_PIG Reviewed; 298 AA.
AC Q4PS85; Q1AG04;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 79.
DE RecName: Full=Myozenin-1;
DE AltName: Full=Calcineurin-interacting protein 2;
DE AltName: Full=Calsarcin-2;
GN Name=MYOZ1;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=16574346; DOI=10.1016/j.gene.2006.01.035;
RA Wang H., Zhu Z., Wang H., Yang S., Mo D., Li K.;
RT "Characterization of different expression patterns of calsarcin-1 and
RT calsarcin-2 in porcine muscle.";
RL Gene 374C:104-111(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Su Y., Liu D., Song H., Zeng R., Kong D., Zhu B., Ba C.;
RT "Cloning and sequencing of calsarcin-2 (myoz1) in skeletal muscle of
RT pigs.";
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC involved in linking Z-disk proteins such as alpha-actinin, gamma-
CC filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC signaling to the sarcomere. Plays an important role in the modulation
CC of calcineurin signaling. May play a role in myofibrillogenesis (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ACTN2, ACTN3, FLNA, FLNB, FLNC, LDB3, PPP3CA
CC and TCAP. Interacts via its C-terminal region with MYOT (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cell projection,
CC pseudopodium {ECO:0000250}. Note=Localized to the nucleus and
CC pseudopodia of undifferentiated cells and detected throughout the
CC myotubes of differentiated cells. Colocalizes with ACTN2, FLNC and MYOT
CC at the Z-lines of skeletal muscle (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR EMBL; DQ143040; ABA12602.1; -; mRNA.
DR EMBL; DQ143042; ABA12604.1; -; Genomic_DNA.
DR EMBL; DQ058294; AAY78933.1; -; mRNA.
DR RefSeq; NP_001020393.1; NM_001025222.2.
DR RefSeq; XP_005671146.1; XM_005671089.2.
DR AlphaFoldDB; Q4PS85; -.
DR PaxDb; Q4PS85; -.
DR PeptideAtlas; Q4PS85; -.
DR PRIDE; Q4PS85; -.
DR Ensembl; ENSSSCT00005023091; ENSSSCP00005013839; ENSSSCG00005014773.
DR Ensembl; ENSSSCT00015107000; ENSSSCP00015045121; ENSSSCG00015078943.
DR Ensembl; ENSSSCT00025045717; ENSSSCP00025019502; ENSSSCG00025033590.
DR Ensembl; ENSSSCT00030104559; ENSSSCP00030048511; ENSSSCG00030074487.
DR Ensembl; ENSSSCT00035097705; ENSSSCP00035041237; ENSSSCG00035072203.
DR Ensembl; ENSSSCT00040005665; ENSSSCP00040002149; ENSSSCG00040004299.
DR Ensembl; ENSSSCT00045019062; ENSSSCP00045013083; ENSSSCG00045011230.
DR Ensembl; ENSSSCT00050055000; ENSSSCP00050023260; ENSSSCG00050040637.
DR Ensembl; ENSSSCT00055053130; ENSSSCP00055042397; ENSSSCG00055026866.
DR Ensembl; ENSSSCT00060101147; ENSSSCP00060043941; ENSSSCG00060073956.
DR Ensembl; ENSSSCT00065007083; ENSSSCP00065003059; ENSSSCG00065005213.
DR Ensembl; ENSSSCT00070010852; ENSSSCP00070008935; ENSSSCG00070005711.
DR GeneID; 574060; -.
DR KEGG; ssc:574060; -.
DR CTD; 58529; -.
DR eggNOG; ENOG502R4N9; Eukaryota.
DR HOGENOM; CLU_071316_0_0_1; -.
DR InParanoid; Q4PS85; -.
DR TreeFam; TF331748; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Chromosome 14.
DR Genevisible; Q4PS85; SS.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR GO; GO:0004865; F:protein serine/threonine phosphatase inhibitor activity; IEA:Ensembl.
DR GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR GO; GO:0043417; P:negative regulation of skeletal muscle tissue regeneration; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR GO; GO:0043503; P:skeletal muscle fiber adaptation; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0042060; P:wound healing; IEA:Ensembl.
DR InterPro; IPR008438; MYOZ.
DR PANTHER; PTHR15941; PTHR15941; 1.
DR Pfam; PF05556; Calsarcin; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..298
FT /note="Myozenin-1"
FT /id="PRO_0000111097"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 105..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..145
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 82
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9JK37"
SQ SEQUENCE 298 AA; 31667 MW; 83F677DB661C0190 CRC64;
MPLSGTPAPN KKRKSSKLIM ELTGGGQESS GLNLGKKISV PRDVMLEELS LLTNRGSKMF
KLRQMRVEKF IYENHPDVFS DSSMDHFQKF LPTVGGQLGT AGQGFSYSKG SSGGQAGGSS
SAGQYGSGQQ HHHQGSGSGS GGAGGPGSQT GRGGDAGTTG VGETGTGDQA GGEGKHITVF
KTYISPWEKA MGVDPHQKVE LGIDLLAYGA KAELPQYKSF NRTAMPYGGY EKASKRMTFQ
MPKFDLGPLL SEPLVLYNQN LSNRPSFNRT PIPWLSSGEP VDYNVDIGIP LDGETEEL