ID   MYOZ2_BOVIN             Reviewed;         264 AA.
AC   Q5E9V3; Q3ZBT3;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Myozenin-2;
DE   AltName: Full=Calsarcin-1;
GN   Name=MYOZ2;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Heart ventricle;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC       involved in linking Z line proteins such as alpha-actinin, gamma-
CC       filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC       signaling to the sarcomere. Plays an important role in the modulation
CC       of calcineurin signaling. May play a role in myofibrillogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts via its C-terminus with spectrin repeats 3 and 4 of
CC       ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of
CC       heart and skeletal muscle. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR   EMBL; BT020817; AAX08834.1; -; mRNA.
DR   EMBL; BC103121; AAI03122.1; -; mRNA.
DR   RefSeq; NP_001015676.1; NM_001015676.1.
DR   AlphaFoldDB; Q5E9V3; -.
DR   STRING; 9913.ENSBTAP00000003330; -.
DR   PaxDb; Q5E9V3; -.
DR   Ensembl; ENSBTAT00000003330; ENSBTAP00000003330; ENSBTAG00000002574.
DR   GeneID; 540487; -.
DR   KEGG; bta:540487; -.
DR   CTD; 51778; -.
DR   VEuPathDB; HostDB:ENSBTAG00000002574; -.
DR   VGNC; VGNC:31841; MYOZ2.
DR   eggNOG; ENOG502QVA2; Eukaryota.
DR   GeneTree; ENSGT00950000183027; -.
DR   HOGENOM; CLU_071316_1_1_1; -.
DR   InParanoid; Q5E9V3; -.
DR   OMA; YTFENFH; -.
DR   OrthoDB; 979261at2759; -.
DR   TreeFam; TF331748; -.
DR   Proteomes; UP000009136; Chromosome 6.
DR   Bgee; ENSBTAG00000002574; Expressed in cardiac ventricle and 67 other tissues.
DR   GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR   GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR   GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR   GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR   GO; GO:0043503; P:skeletal muscle fiber adaptation; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   InterPro; IPR008438; MYOZ.
DR   PANTHER; PTHR15941; PTHR15941; 1.
DR   Pfam; PF05556; Calsarcin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..264
FT                   /note="Myozenin-2"
FT                   /id="PRO_0000111098"
FT   REGION          98..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..124
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         101
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         107
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         111
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   CONFLICT        22
FT                   /note="I -> V (in Ref. 2; AAI03122)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   264 AA;  30151 MW;  8F407F42225F4A55 CRC64;
     MLSHNTMVKQ RKQQASAIMK EIHGNDVDVM HLGKKVSIPR DIMLEELSHL SNRGARLFKM
     RQRRSDKYTF ENFQYETKAQ INHNIAMQNE KLDGINLESG SQQAPFTPPN TPDPRSPPNP
     ENIAPGYSGP LKEIPPERFN TTAVPKYYQS PWEQAISNDP ELLEALYPKF FKPEGKAELP
     DYRSFNRVAT PFGGFEKASK MVKFKVPDFD LLLLTDPRFM AFANPLSGRR SFNRTPKGWI
     SENIPIVITT EPTEDNTIPE SEDL