ID   MYOZ2_PONAB             Reviewed;         264 AA.
AC   Q5R6I2;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 72.
DE   RecName: Full=Myozenin-2;
DE   AltName: Full=Calsarcin-1;
GN   Name=MYOZ2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC       involved in linking Z line proteins such as alpha-actinin, gamma-
CC       filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC       signaling to the sarcomere. Plays an important role in the modulation
CC       of calcineurin signaling. May play a role in myofibrillogenesis (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts via its C-terminus with spectrin repeats 3 and 4 of
CC       ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC       {ECO:0000250}. Note=Colocalizes with ACTN1 and PPP3CA at the Z-line of
CC       heart and skeletal muscle. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR   EMBL; CR860507; CAH92629.1; -; mRNA.
DR   RefSeq; NP_001126540.1; NM_001133068.1.
DR   AlphaFoldDB; Q5R6I2; -.
DR   STRING; 9601.ENSPPYP00000016781; -.
DR   Ensembl; ENSPPYT00000017461; ENSPPYP00000016781; ENSPPYG00000015023.
DR   GeneID; 100173530; -.
DR   KEGG; pon:100173530; -.
DR   CTD; 51778; -.
DR   eggNOG; ENOG502QVA2; Eukaryota.
DR   GeneTree; ENSGT00950000183027; -.
DR   HOGENOM; CLU_071316_1_1_1; -.
DR   InParanoid; Q5R6I2; -.
DR   OMA; YTFENFH; -.
DR   OrthoDB; 979261at2759; -.
DR   TreeFam; TF331748; -.
DR   Proteomes; UP000001595; Chromosome 4.
DR   GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
DR   GO; GO:0003779; F:actin binding; IEA:Ensembl.
DR   GO; GO:0031433; F:telethonin binding; IEA:Ensembl.
DR   GO; GO:0070885; P:negative regulation of calcineurin-NFAT signaling cascade; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045214; P:sarcomere organization; IEA:Ensembl.
DR   GO; GO:0043503; P:skeletal muscle fiber adaptation; IEA:Ensembl.
DR   GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR   InterPro; IPR008438; MYOZ.
DR   PANTHER; PTHR15941; PTHR15941; 1.
DR   Pfam; PF05556; Calsarcin; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Methylation; Phosphoprotein; Reference proteome.
FT   CHAIN           1..264
FT                   /note="Myozenin-2"
FT                   /id="PRO_0000111101"
FT   REGION          90..135
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        90..106
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..124
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         53
FT                   /note="Omega-N-methylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         101
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         107
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         111
FT                   /note="Phosphothreonine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
FT   MOD_RES         116
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9JJW5"
SQ   SEQUENCE   264 AA;  29866 MW;  8367BEF793888916 CRC64;
     MLSHNTMVKQ RKQQATAIMK EVHGNDVDGM DLGKKVSIPR DIMLEELSHL SNRGARLFKM
     RQRRSDKYTF ENFQYQSRAQ INHSIAMQNG KVDGSNLEGG SQQAPLTPPN TPDPRSPPNP
     DNIAPGYSGP LKEIPPEKFN TTAVPKYYQS PWEQAISNDP ELLEALYPKL FKPEGKAELP
     DYRSFNRVAT PFGGFEKASR MVKFKVPDFE LLLLTDPRFM SFVNPLSGRR SFNRTPKGWI
     SENIPIVITT EPTDDTTVPE SEDL