MYOZ3_HUMAN
ID MYOZ3_HUMAN Reviewed; 251 AA.
AC Q8TDC0; B2R9Q4; D3DQG9; Q8IVM1; Q8IVN1;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Myozenin-3;
DE AltName: Full=Calsarcin-3;
DE AltName: Full=FATZ-related protein 3;
GN Name=MYOZ3 {ECO:0000312|HGNC:HGNC:18565};
GN Synonyms=FRP3 {ECO:0000312|EMBL:CAC83076.1};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL79336.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT PRO-161, INTERACTION WITH
RP ACTN2; FLNC; LDB3; PPP3CA AND TCAP, AND TISSUE SPECIFICITY.
RX PubMed=11842093; DOI=10.1074/jbc.m200712200;
RA Frey N., Olson E.N.;
RT "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin
RT family, interacts with multiple Z-disc proteins.";
RL J. Biol. Chem. 277:13998-14004(2002).
RN [2] {ECO:0000305, ECO:0000312|EMBL:CAC83076.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANT PRO-161.
RC TISSUE=Skeletal muscle {ECO:0000312|EMBL:CAC83076.1};
RA Scannapieco P., Greggio E., Bortoletto G., Ievolella C., Lanfranchi G.;
RT "New muscular proteins.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-161.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [5] {ECO:0000305, ECO:0000312|EMBL:CAC83076.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT PRO-161.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000305, ECO:0000312|EMBL:AAH69380.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT PRO-161.
RC TISSUE=Lung {ECO:0000312|EMBL:AAH74871.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC involved in linking Z line proteins such as alpha-actinin, gamma-
CC filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC signaling to the sarcomere. Plays an important role in the modulation
CC of calcineurin signaling. May play a role in myofibrillogenesis.
CC -!- SUBUNIT: Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.
CC {ECO:0000269|PubMed:11842093}.
CC -!- INTERACTION:
CC Q8TDC0; Q9NYB9-2: ABI2; NbExp=3; IntAct=EBI-5662487, EBI-11096309;
CC Q8TDC0; Q53H80: AKIRIN2; NbExp=3; IntAct=EBI-5662487, EBI-742928;
CC Q8TDC0; Q86U10: ASPG; NbExp=3; IntAct=EBI-5662487, EBI-19946665;
CC Q8TDC0; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-5662487, EBI-8624731;
CC Q8TDC0; O95429: BAG4; NbExp=3; IntAct=EBI-5662487, EBI-2949658;
CC Q8TDC0; O75934: BCAS2; NbExp=3; IntAct=EBI-5662487, EBI-1050106;
CC Q8TDC0; Q5SWW7: C10orf55; NbExp=3; IntAct=EBI-5662487, EBI-12809220;
CC Q8TDC0; Q8WW14-2: C10orf82; NbExp=3; IntAct=EBI-5662487, EBI-12831628;
CC Q8TDC0; Q2TAC2-2: CCDC57; NbExp=3; IntAct=EBI-5662487, EBI-10961624;
CC Q8TDC0; Q03060-25: CREM; NbExp=3; IntAct=EBI-5662487, EBI-12884642;
CC Q8TDC0; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-5662487, EBI-2872414;
CC Q8TDC0; Q15038: DAZAP2; NbExp=3; IntAct=EBI-5662487, EBI-724310;
CC Q8TDC0; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-5662487, EBI-9679045;
CC Q8TDC0; O43281-2: EFS; NbExp=3; IntAct=EBI-5662487, EBI-11525448;
CC Q8TDC0; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-5662487, EBI-744099;
CC Q8TDC0; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-5662487, EBI-742102;
CC Q8TDC0; A8MTA8-2: FAM166B; NbExp=3; IntAct=EBI-5662487, EBI-12160437;
CC Q8TDC0; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-5662487, EBI-12193763;
CC Q8TDC0; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-5662487, EBI-745689;
CC Q8TDC0; Q13643: FHL3; NbExp=3; IntAct=EBI-5662487, EBI-741101;
CC Q8TDC0; Q5TD97: FHL5; NbExp=3; IntAct=EBI-5662487, EBI-750641;
CC Q8TDC0; O75603: GCM2; NbExp=3; IntAct=EBI-5662487, EBI-10188645;
CC Q8TDC0; Q9NYA3: GOLGA6A; NbExp=3; IntAct=EBI-5662487, EBI-11163335;
CC Q8TDC0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-5662487, EBI-5916454;
CC Q8TDC0; A0A024R8L2: hCG_1987119; NbExp=3; IntAct=EBI-5662487, EBI-14103818;
CC Q8TDC0; O75031: HSF2BP; NbExp=3; IntAct=EBI-5662487, EBI-7116203;
CC Q8TDC0; Q63ZY3: KANK2; NbExp=3; IntAct=EBI-5662487, EBI-2556193;
CC Q8TDC0; O76011: KRT34; NbExp=3; IntAct=EBI-5662487, EBI-1047093;
CC Q8TDC0; O76013-2: KRT36; NbExp=3; IntAct=EBI-5662487, EBI-11958506;
CC Q8TDC0; O95678: KRT75; NbExp=3; IntAct=EBI-5662487, EBI-2949715;
CC Q8TDC0; Q3LI72: KRTAP19-5; NbExp=3; IntAct=EBI-5662487, EBI-1048945;
CC Q8TDC0; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-5662487, EBI-12805508;
CC Q8TDC0; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-5662487, EBI-12111050;
CC Q8TDC0; Q8IUC3: KRTAP7-1; NbExp=3; IntAct=EBI-5662487, EBI-18394498;
CC Q8TDC0; Q8IUC2: KRTAP8-1; NbExp=5; IntAct=EBI-5662487, EBI-10261141;
CC Q8TDC0; Q16719-2: KYNU; NbExp=3; IntAct=EBI-5662487, EBI-12351611;
CC Q8TDC0; Q96PV6: LENG8; NbExp=3; IntAct=EBI-5662487, EBI-739546;
CC Q8TDC0; P25791-3: LMO2; NbExp=3; IntAct=EBI-5662487, EBI-11959475;
CC Q8TDC0; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-5662487, EBI-11742507;
CC Q8TDC0; P61968: LMO4; NbExp=3; IntAct=EBI-5662487, EBI-2798728;
CC Q8TDC0; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-5662487, EBI-2341787;
CC Q8TDC0; Q6PF18: MORN3; NbExp=3; IntAct=EBI-5662487, EBI-9675802;
CC Q8TDC0; Q96DV4: MRPL38; NbExp=3; IntAct=EBI-5662487, EBI-720441;
CC Q8TDC0; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-5662487, EBI-11750983;
CC Q8TDC0; P61970: NUTF2; NbExp=3; IntAct=EBI-5662487, EBI-591778;
CC Q8TDC0; P78337: PITX1; NbExp=3; IntAct=EBI-5662487, EBI-748265;
CC Q8TDC0; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-5662487, EBI-11339910;
CC Q8TDC0; Q9NQX0: PRDM6; NbExp=3; IntAct=EBI-5662487, EBI-11320284;
CC Q8TDC0; P28070: PSMB4; NbExp=3; IntAct=EBI-5662487, EBI-603350;
CC Q8TDC0; Q13882: PTK6; NbExp=3; IntAct=EBI-5662487, EBI-1383632;
CC Q8TDC0; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-5662487, EBI-726876;
CC Q8TDC0; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-5662487, EBI-6257312;
CC Q8TDC0; Q96SF7: TBX15; NbExp=3; IntAct=EBI-5662487, EBI-10191361;
CC Q8TDC0; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-5662487, EBI-750487;
CC Q8TDC0; O75865-2: TRAPPC6A; NbExp=3; IntAct=EBI-5662487, EBI-8451480;
CC Q8TDC0; Q86WV8: TSC1; NbExp=3; IntAct=EBI-5662487, EBI-12806590;
CC Q8TDC0; Q96PN8: TSSK3; NbExp=3; IntAct=EBI-5662487, EBI-3918381;
CC Q8TDC0; Q6NVU6: UFSP1; NbExp=3; IntAct=EBI-5662487, EBI-12068150;
CC Q8TDC0; Q6ZNG0: ZNF620; NbExp=3; IntAct=EBI-5662487, EBI-4395669;
CC Q8TDC0; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-5662487, EBI-4395732;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000250}. Note=Localized at the Z-line of skeletal muscle.
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1 {ECO:0000269|PubMed:11842093};
CC IsoId=Q8TDC0-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|Ref.2};
CC IsoId=Q8TDC0-2; Sequence=VSP_051879;
CC Name=3 {ECO:0000269|Ref.2};
CC IsoId=Q8TDC0-3; Sequence=VSP_051876, VSP_051877, VSP_051878;
CC -!- TISSUE SPECIFICITY: Expressed specifically in skeletal muscle. Not
CC detected in heart. {ECO:0000269|PubMed:11842093}.
CC -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR EMBL; AF480443; AAL79336.1; -; mRNA.
DR EMBL; AJ277961; CAC81912.1; -; mRNA.
DR EMBL; AJ300586; CAC83076.1; -; mRNA.
DR EMBL; AJ300587; CAC83077.1; -; mRNA.
DR EMBL; AK313873; BAG36601.1; -; mRNA.
DR EMBL; AC008453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471062; EAW61713.1; -; Genomic_DNA.
DR EMBL; CH471062; EAW61714.1; -; Genomic_DNA.
DR EMBL; BC069380; AAH69380.1; -; mRNA.
DR EMBL; BC069553; AAH69553.1; -; mRNA.
DR EMBL; BC074870; AAH74870.1; -; mRNA.
DR EMBL; BC074871; AAH74871.1; -; mRNA.
DR CCDS; CCDS4309.1; -. [Q8TDC0-1]
DR RefSeq; NP_001116325.1; NM_001122853.2. [Q8TDC0-1]
DR RefSeq; NP_588612.2; NM_133371.4. [Q8TDC0-1]
DR AlphaFoldDB; Q8TDC0; -.
DR BioGRID; 124899; 66.
DR IntAct; Q8TDC0; 62.
DR MINT; Q8TDC0; -.
DR STRING; 9606.ENSP00000297130; -.
DR iPTMnet; Q8TDC0; -.
DR PhosphoSitePlus; Q8TDC0; -.
DR BioMuta; MYOZ3; -.
DR DMDM; 296439236; -.
DR MassIVE; Q8TDC0; -.
DR PaxDb; Q8TDC0; -.
DR PeptideAtlas; Q8TDC0; -.
DR PRIDE; Q8TDC0; -.
DR ProteomicsDB; 74261; -. [Q8TDC0-1]
DR ProteomicsDB; 74262; -. [Q8TDC0-2]
DR ProteomicsDB; 74263; -. [Q8TDC0-3]
DR Antibodypedia; 50777; 28 antibodies from 13 providers.
DR DNASU; 91977; -.
DR Ensembl; ENST00000297130.4; ENSP00000297130.4; ENSG00000164591.14. [Q8TDC0-1]
DR Ensembl; ENST00000517768.6; ENSP00000428815.1; ENSG00000164591.14. [Q8TDC0-1]
DR Ensembl; ENST00000615557.1; ENSP00000478375.1; ENSG00000164591.14. [Q8TDC0-3]
DR GeneID; 91977; -.
DR KEGG; hsa:91977; -.
DR MANE-Select; ENST00000517768.6; ENSP00000428815.1; NM_001122853.3; NP_001116325.1.
DR UCSC; uc003lsr.4; human. [Q8TDC0-1]
DR CTD; 91977; -.
DR DisGeNET; 91977; -.
DR GeneCards; MYOZ3; -.
DR HGNC; HGNC:18565; MYOZ3.
DR HPA; ENSG00000164591; Group enriched (skeletal muscle, tongue).
DR MIM; 610735; gene.
DR neXtProt; NX_Q8TDC0; -.
DR OpenTargets; ENSG00000164591; -.
DR PharmGKB; PA38577; -.
DR VEuPathDB; HostDB:ENSG00000164591; -.
DR eggNOG; ENOG502S22C; Eukaryota.
DR GeneTree; ENSGT00950000183027; -.
DR HOGENOM; CLU_071316_1_0_1; -.
DR InParanoid; Q8TDC0; -.
DR OMA; RSELHIY; -.
DR OrthoDB; 979261at2759; -.
DR PhylomeDB; Q8TDC0; -.
DR TreeFam; TF331748; -.
DR PathwayCommons; Q8TDC0; -.
DR SignaLink; Q8TDC0; -.
DR BioGRID-ORCS; 91977; 13 hits in 1071 CRISPR screens.
DR GenomeRNAi; 91977; -.
DR Pharos; Q8TDC0; Tdark.
DR PRO; PR:Q8TDC0; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q8TDC0; protein.
DR Bgee; ENSG00000164591; Expressed in skeletal muscle tissue of rectus abdominis and 149 other tissues.
DR ExpressionAtlas; Q8TDC0; baseline and differential.
DR Genevisible; Q8TDC0; HS.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IBA:GO_Central.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR InterPro; IPR008438; MYOZ.
DR PANTHER; PTHR15941; PTHR15941; 1.
DR Pfam; PF05556; Calsarcin; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..251
FT /note="Myozenin-3"
FT /id="PRO_0000111102"
FT REGION 50..67
FT /note="Binding to ACTN2, PPP3CA and TCAP"
FT /evidence="ECO:0000269|PubMed:11842093"
FT REGION 67..110
FT /note="Binding to FLNC"
FT /evidence="ECO:0000269|PubMed:11842093"
FT REGION 79..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 186..207
FT /note="Binding to ACTN2"
FT /evidence="ECO:0000269|PubMed:11842093"
FT COMPBIAS 83..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8R4E4"
FT VAR_SEQ 1..20
FT /note="MIPKEQKGPVMAAMGDLTEP -> MLREVGPGVYGGWGGESPLWPFLA (in
FT isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_051876"
FT VAR_SEQ 73..83
FT /note="MLAGSARRKVT -> VSKPPLCSWGK (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_051877"
FT VAR_SEQ 84..251
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_051878"
FT VAR_SEQ 186..231
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_051879"
FT VARIANT 161
FT /note="S -> P (in dbSNP:rs194134)"
FT /evidence="ECO:0000269|PubMed:11842093,
FT ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:15489334,
FT ECO:0000269|Ref.2, ECO:0000269|Ref.5"
FT /id="VAR_067718"
FT VARIANT 209
FT /note="T -> N (in dbSNP:rs7737542)"
FT /id="VAR_056203"
SQ SEQUENCE 251 AA; 27157 MW; AF1C09E49CD31D94 CRC64;
MIPKEQKGPV MAAMGDLTEP VPTLDLGKKL SVPQDLMMEE LSLRNNRGSL LFQKRQRRVQ
KFTFELAASQ RAMLAGSARR KVTGTAESGT VANANGPEGP NYRSELHIFP ASPGASLGGP
EGAHPAAAPA GCVPSPSALA PGYAEPLKGV PPEKFNHTAI SKGYRCPWQE FVSYRDYQSD
GRSHTPSPND YRNFNKTPVP FGGPLVGGTF PRPGTPFIPE PLSGLELLRL RPSFNRVAQG
WVRNLPESEE L
