MYOZ3_MOUSE
ID MYOZ3_MOUSE Reviewed; 245 AA.
AC Q8R4E4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 25-MAY-2022, entry version 105.
DE RecName: Full=Myozenin-3;
DE AltName: Full=Calsarcin-3;
DE AltName: Full=FATZ-related protein 3;
GN Name=Myoz3 {ECO:0000312|MGI:MGI:2179296};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAL79335.1}
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:AAL79335.1};
RC TISSUE=Skeletal muscle {ECO:0000312|EMBL:AAL79335.1};
RX PubMed=11842093; DOI=10.1074/jbc.m200712200;
RA Frey N., Olson E.N.;
RT "Calsarcin-3, a novel skeletal muscle-specific member of the calsarcin
RT family, interacts with multiple Z-disc proteins.";
RL J. Biol. Chem. 277:13998-14004(2002).
RN [2] {ECO:0000312|EMBL:AAI04047.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-31, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, and Lung;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Myozenins may serve as intracellular binding proteins
CC involved in linking Z line proteins such as alpha-actinin, gamma-
CC filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin
CC signaling to the sarcomere. Plays an important role in the modulation
CC of calcineurin signaling. May play a role in myofibrillogenesis.
CC -!- SUBUNIT: Interacts with ACTN2, LDB3, FLNC, PPP3CA and TCAP.
CC {ECO:0000250|UniProtKB:Q8TDC0}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, Z line
CC {ECO:0000269|PubMed:11842093}. Note=Localized at the Z-line of skeletal
CC muscle.
CC -!- TISSUE SPECIFICITY: Expressed specifically in skeletal muscle and is
CC enriched in fast-twitch muscle fibers. Not detected in heart.
CC {ECO:0000269|PubMed:11842093}.
CC -!- SIMILARITY: Belongs to the myozenin family. {ECO:0000305}.
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DR EMBL; AF480442; AAL79335.1; -; mRNA.
DR EMBL; BC104046; AAI04047.1; -; mRNA.
DR EMBL; BC104047; AAI04048.1; -; mRNA.
DR CCDS; CCDS29273.1; -.
DR RefSeq; NP_579941.2; NM_133363.3.
DR AlphaFoldDB; Q8R4E4; -.
DR SMR; Q8R4E4; -.
DR STRING; 10090.ENSMUSP00000063108; -.
DR iPTMnet; Q8R4E4; -.
DR PhosphoSitePlus; Q8R4E4; -.
DR MaxQB; Q8R4E4; -.
DR PaxDb; Q8R4E4; -.
DR PRIDE; Q8R4E4; -.
DR ProteomicsDB; 287340; -.
DR DNASU; 170947; -.
DR GeneID; 170947; -.
DR KEGG; mmu:170947; -.
DR CTD; 91977; -.
DR MGI; MGI:2179296; Myoz3.
DR eggNOG; ENOG502S22C; Eukaryota.
DR InParanoid; Q8R4E4; -.
DR OrthoDB; 979261at2759; -.
DR PhylomeDB; Q8R4E4; -.
DR BioGRID-ORCS; 170947; 0 hits in 71 CRISPR screens.
DR ChiTaRS; Myoz3; mouse.
DR PRO; PR:Q8R4E4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8R4E4; protein.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:GO_Central.
DR GO; GO:0030018; C:Z disc; IDA:MGI.
DR GO; GO:0003779; F:actin binding; IBA:GO_Central.
DR GO; GO:0051373; F:FATZ binding; IBA:GO_Central.
DR GO; GO:0031433; F:telethonin binding; IBA:GO_Central.
DR InterPro; IPR008438; MYOZ.
DR PANTHER; PTHR15941; PTHR15941; 1.
DR Pfam; PF05556; Calsarcin; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..245
FT /note="Myozenin-3"
FT /id="PRO_0000111103"
FT REGION 50..67
FT /note="Binding to ACTN2, PPP3CA and TCAP"
FT /evidence="ECO:0000250|UniProtKB:Q8TDC0"
FT REGION 67..108
FT /note="Binding to FLNC"
FT /evidence="ECO:0000250|UniProtKB:Q8TDC0"
FT REGION 93..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..201
FT /note="Binding to ACTN2"
FT /evidence="ECO:0000250|UniProtKB:Q8TDC0"
FT MOD_RES 31
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
SQ SEQUENCE 245 AA; 26982 MW; CF3FB6C4114FF03E CRC64;
MIPKEQKEPV MAVPGDLAEP VPSLDLGKKL SVPQDLMIEE LSLRNNRGSL LFQKRQRRVQ
KFTFELSESL QAILASSARG KVAGRAAQAT VPNGLEEQNH HSETHVFQGS PGDPGITHLG
AAGTGSVRSP SALAPGYAEP LKGVPPEKFN HTAIPKGYRC PWQEFTSYQD YSSGSRSHTP
IPRDYRNFNK TPVPFGGPHV REAIFHAGTP FVPESFSGLE LLRLRPNFNR VAQGWVRKLP
ESEEL
