ID   MYP0_XENTR              Reviewed;         243 AA.
AC   A0JM41;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Myelin protein P0;
DE   AltName: Full=Myelin peripheral protein;
DE            Short=MPP;
DE   AltName: Full=Myelin protein zero;
DE   Flags: Precursor;
GN   Name=mpz;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Creation of an extracellular membrane face which guides the
CC       wrapping process and ultimately compacts adjacent lamellae.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC       membrane protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the myelin P0 protein family. {ECO:0000305}.
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DR   EMBL; BC125729; AAI25730.1; -; mRNA.
DR   RefSeq; NP_001072741.1; NM_001079273.1.
DR   AlphaFoldDB; A0JM41; -.
DR   SMR; A0JM41; -.
DR   STRING; 8364.ENSXETP00000060043; -.
DR   PaxDb; A0JM41; -.
DR   DNASU; 780198; -.
DR   Ensembl; ENSXETT00000062665; ENSXETP00000060043; ENSXETG00000034086.
DR   GeneID; 780198; -.
DR   KEGG; xtr:780198; -.
DR   CTD; 4359; -.
DR   Xenbase; XB-GENE-876969; mpz.
DR   eggNOG; ENOG502QVJ0; Eukaryota.
DR   InParanoid; A0JM41; -.
DR   OrthoDB; 1440680at2759; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034086; Expressed in skeletal muscle tissue and 7 other tissues.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
DR   GO; GO:0043209; C:myelin sheath; IEA:InterPro.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0042552; P:myelination; IBA:GO_Central.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR029869; Myelin_P0.
DR   InterPro; IPR000920; Myelin_P0-rel.
DR   InterPro; IPR019566; MYP0_C.
DR   PANTHER; PTHR13869; PTHR13869; 1.
DR   PANTHER; PTHR13869:SF7; PTHR13869:SF7; 1.
DR   Pfam; PF10570; Myelin-PO_C; 1.
DR   Pfam; PF07686; V-set; 1.
DR   PRINTS; PR00213; MYELINP0.
DR   SMART; SM00409; IG; 1.
DR   SMART; SM00406; IGv; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Reference proteome; Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..243
FT                   /note="Myelin protein P0"
FT                   /id="PRO_0000376827"
FT   TOPO_DOM        27..154
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..175
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        176..243
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          27..141
FT                   /note="Ig-like V-type"
FT   REGION          201..243
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        223..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        118
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        47..123
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   243 AA;  27093 MW;  FDD028A03DDDB592 CRC64;
     MESSGLRAPC SLLVLLSALV LPPTLAIEVY TDREVYGTVG SRVTLSCSFW SSEWISDDVS
     VTWHYQPDHS REMYSIFHYA KGQPSIDAGV FKDRIEWVGS PKWKDASIVL HNLELIDNGT
     FTCDVKNPPD VVGKSSYVHL QVQEKGAARA GLVLGIIIAV ALALVIVVTI LILLIRYCWL
     RRQVRVQREL SALERGKLHK AKDSSKRSSR QTPILYAMLD QTRGKASEKK GKGGIGDSRK
     DRK