MYP2_MOUSE
ID MYP2_MOUSE Reviewed; 132 AA.
AC P24526; Q4KL10;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Myelin P2 protein;
GN Name=Pmp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1711100; DOI=10.1111/j.1471-4159.1991.tb02101.x;
RA Narayanan V., Kaestner K.H., Tennekoon G.I.;
RT "Structure of the mouse myelin P2 protein gene.";
RL J. Neurochem. 57:75-80(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in lipid transport protein in Schwann cells.
CC May bind cholesterol (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Monomer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic
CC ligands in its interior. {ECO:0000250}.
CC -!- MISCELLANEOUS: P2 protein and myelin basic protein together constitute
CC a major fraction of peripheral nervous system myelin protein.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding
CC protein (FABP) family. {ECO:0000305}.
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DR EMBL; S39508; AAB19249.2; -; Genomic_DNA.
DR EMBL; BC099520; AAH99520.1; -; mRNA.
DR CCDS; CCDS17236.1; -.
DR PIR; JH0407; JH0407.
DR RefSeq; NP_001025476.1; NM_001030305.2.
DR AlphaFoldDB; P24526; -.
DR SMR; P24526; -.
DR IntAct; P24526; 1.
DR STRING; 10090.ENSMUSP00000029034; -.
DR iPTMnet; P24526; -.
DR PhosphoSitePlus; P24526; -.
DR jPOST; P24526; -.
DR MaxQB; P24526; -.
DR PaxDb; P24526; -.
DR PeptideAtlas; P24526; -.
DR PRIDE; P24526; -.
DR ProteomicsDB; 252632; -.
DR Antibodypedia; 25321; 176 antibodies from 22 providers.
DR Ensembl; ENSMUST00000029034; ENSMUSP00000029034; ENSMUSG00000052468.
DR GeneID; 18857; -.
DR KEGG; mmu:18857; -.
DR UCSC; uc008oph.1; mouse.
DR CTD; 5375; -.
DR MGI; MGI:102667; Pmp2.
DR VEuPathDB; HostDB:ENSMUSG00000052468; -.
DR eggNOG; KOG4015; Eukaryota.
DR GeneTree; ENSGT00940000160445; -.
DR HOGENOM; CLU_113772_0_0_1; -.
DR InParanoid; P24526; -.
DR OMA; CIMGDVI; -.
DR OrthoDB; 1417203at2759; -.
DR PhylomeDB; P24526; -.
DR TreeFam; TF316894; -.
DR BioGRID-ORCS; 18857; 4 hits in 75 CRISPR screens.
DR PRO; PR:P24526; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; P24526; protein.
DR Bgee; ENSMUSG00000052468; Expressed in morula and 14 other tissues.
DR Genevisible; P24526; MM.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0043209; C:myelin sheath; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0015485; F:cholesterol binding; ISS:UniProtKB.
DR GO; GO:0005504; F:fatty acid binding; ISS:UniProtKB.
DR GO; GO:0015908; P:fatty acid transport; IBA:GO_Central.
DR GO; GO:0061024; P:membrane organization; IDA:MGI.
DR Gene3D; 2.40.128.20; -; 1.
DR InterPro; IPR012674; Calycin.
DR InterPro; IPR000463; Fatty_acid-bd.
DR InterPro; IPR031259; ILBP.
DR InterPro; IPR000566; Lipocln_cytosolic_FA-bd_dom.
DR InterPro; IPR031256; Myelin_P2.
DR PANTHER; PTHR11955; PTHR11955; 1.
DR PANTHER; PTHR11955:SF64; PTHR11955:SF64; 1.
DR Pfam; PF00061; Lipocalin; 1.
DR PRINTS; PR00178; FATTYACIDBP.
DR SUPFAM; SSF50814; SSF50814; 1.
DR PROSITE; PS00214; FABP; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Lipid-binding; Reference proteome; Transport.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02690"
FT CHAIN 2..132
FT /note="Myelin P2 protein"
FT /id="PRO_0000067389"
FT BINDING 107
FT /ligand="(9Z)-octadecenoate"
FT /ligand_id="ChEBI:CHEBI:30823"
FT /evidence="ECO:0000250|UniProtKB:P02690"
FT BINDING 107
FT /ligand="hexadecanoate"
FT /ligand_id="ChEBI:CHEBI:7896"
FT /evidence="ECO:0000250|UniProtKB:P02689"
FT BINDING 127..129
FT /ligand="(9Z)-octadecenoate"
FT /ligand_id="ChEBI:CHEBI:30823"
FT /evidence="ECO:0000250|UniProtKB:P02690"
FT BINDING 127..129
FT /ligand="hexadecanoate"
FT /ligand_id="ChEBI:CHEBI:7896"
FT /evidence="ECO:0000250|UniProtKB:P02689"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P02690"
SQ SEQUENCE 132 AA; 14935 MW; AB6A4E7F3834107C CRC64;
MSNKFLGTWK LVSSEHFDDY MKALGVGLAN RKLGNLAKPT VIISKKGDYI TIRTESAFKN
TEISFKLGQE FDETTADNRK AKSIVTLERG SLKQVQKWDG KETAIRRTLL DGRMVVECIM
KGVVCTRIYE KV
