ID   MYPC3_AMBME             Reviewed;         510 AA.
AC   Q90233;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Myosin-binding protein C, cardiac-type;
DE            Short=Cardiac MyBP-C;
DE   AltName: Full=C-protein, cardiac muscle isoform;
DE   AltName: Full=CPRO axocard 1;
DE   Flags: Fragment;
OS   Ambystoma mexicanum (Axolotl).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Caudata; Salamandroidea; Ambystomatidae; Ambystoma.
OX   NCBI_TaxID=8296;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Heart muscle;
RX   PubMed=7639739; DOI=10.1006/bbrc.1995.2120;
RA   Ward S.M., Lemanski L.F., Eiginel-Unaltuna N., Dube D.K.;
RT   "Cloning, sequencing and expression of an isoform of cardiac C-protein from
RT   the Mexican axolotl (Ambystoma mexicanum).";
RL   Biochem. Biophys. Res. Commun. 213:225-231(1995).
CC   -!- FUNCTION: Thick filament-associated protein located in the crossbridge
CC       region of vertebrate striated muscle a bands. In vitro it binds MHC, F-
CC       actin and native thin filaments, and modifies the activity of actin-
CC       activated myosin ATPase. It may modulate muscle contraction or may play
CC       a more structural role (By similarity). {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Heart.
CC   -!- DEVELOPMENTAL STAGE: Expression begins between stage 30 and 35/36 in
CC       the heart and at stages 35-41 in skeletal muscles. Level of expression
CC       in the juvenile skeletal muscle is significantly lower compared to
CC       embryonic skeletal muscle.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. MyBP family.
CC       {ECO:0000305}.
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DR   EMBL; L43560; AAB02791.1; -; mRNA.
DR   PIR; PC4054; PC4054.
DR   AlphaFoldDB; Q90233; -.
DR   SMR; Q90233; -.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.10; -; 5.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR013098; Ig_I-set.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR040849; MyBP-C_THB.
DR   Pfam; PF07679; I-set; 2.
DR   Pfam; PF18362; THB; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; SSF48726; 4.
DR   PROSITE; PS50835; IG_LIKE; 2.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell adhesion; Immunoglobulin domain; Muscle protein;
KW   Repeat; Thick filament.
FT   CHAIN           <1..>510
FT                   /note="Myosin-binding protein C, cardiac-type"
FT                   /id="PRO_0000072697"
FT   DOMAIN          177..269
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          270..347
FT                   /note="Ig-like C2-type 2"
FT   DOMAIN          378..438
FT                   /note="Ig-like C2-type 3"
FT   NON_TER         1
FT   NON_TER         510
SQ   SEQUENCE   510 AA;  57769 MW;  28756DC91D6F198C CRC64;
     ARVKSENLLK KPVVKWFKGK WMDLGTKVGK HLQLQETYDR NTKIYTFEIH IIKAKTTYAG
     GYRCEAVSKD KFDSCNFNLN MHEASNAGEV DIRSAFRRTG DGKEEAGELD FSALLKKRDS
     FLLCESRQMK AEGHPRLMSG KSEGASPSEY EKIAFQYGIT DLRGLLKRLK KMKKEEKKST
     AFLKKLDPAY QVDKGQKIKL VVEVANPDAE VKWKKNGQDI KSSRTKYIFE SIGNKRILTI
     NHCSLADDAA YECVIGDEKC FTELFVKEPP YSSHAPLEDQ MVMVGERVEF ECEVSEEGAQ
     VKWEKDGAEL TREETFNYRF KKDGWQETYL LINEPTKEDS GHYTVKTNGW ESVANLWVQE
     KSVLEVLQEV ADLTVMARDQ AVFKCEVSDE NVKGVWVKNG KEVVPNDRIT IRHIGRTHKL
     TIDNVVVAED EGDYSFIPDG FAFNLSAKLK FLEIKIDFVP RQEPPKINLD VMGPAADTIV
     VVAGNKLRLD VPISGTPAPT VIWTKGNKVG