MYPR_CHICK
ID MYPR_CHICK Reviewed; 277 AA.
AC P23289;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Myelin proteolipid protein;
DE Short=PLP;
DE AltName: Full=Lipophilin;
GN Name=PLP1; Synonyms=PLP;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Brain;
RX PubMed=1722981; DOI=10.1515/bchm3.1991.372.2.865;
RA Schliess F., Stoffel W.;
RT "Evolution of the myelin integral membrane proteins of the central nervous
RT system.";
RL Biol. Chem. Hoppe-Seyler 372:865-874(1991).
CC -!- FUNCTION: This is the major myelin protein from the central nervous
CC system. It plays an important role in the formation or maintenance of
CC the multilamellar structure of myelin.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the myelin proteolipid protein family.
CC {ECO:0000305}.
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DR EMBL; X61661; CAA43839.1; -; mRNA.
DR PIR; S17600; S17600.
DR RefSeq; NP_990608.1; NM_205277.1.
DR AlphaFoldDB; P23289; -.
DR STRING; 9031.ENSGALP00000000160; -.
DR GeneID; 396214; -.
DR KEGG; gga:396214; -.
DR CTD; 5354; -.
DR VEuPathDB; HostDB:geneid_396214; -.
DR eggNOG; KOG4800; Eukaryota.
DR InParanoid; P23289; -.
DR OrthoDB; 914457at2759; -.
DR PhylomeDB; P23289; -.
DR PRO; PR:P23289; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043209; C:myelin sheath; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0019911; F:structural constituent of myelin sheath; IBA:GO_Central.
DR GO; GO:0061564; P:axon development; IBA:GO_Central.
DR GO; GO:0022010; P:central nervous system myelination; IBA:GO_Central.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR InterPro; IPR001614; Myelin_PLP.
DR InterPro; IPR018237; Myelin_PLP_CS.
DR PANTHER; PTHR11683; PTHR11683; 1.
DR Pfam; PF01275; Myelin_PLP; 1.
DR PRINTS; PR00214; MYELINPLP.
DR SMART; SM00002; PLP; 1.
DR PROSITE; PS00575; MYELIN_PLP_1; 1.
DR PROSITE; PS01004; MYELIN_PLP_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Disulfide bond; Lipoprotein;
KW Membrane; Palmitate; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT INIT_MET 1
FT /note="Removed"
FT CHAIN 2..277
FT /note="Myelin proteolipid protein"
FT /id="PRO_0000159010"
FT TOPO_DOM 2..10
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 11..36
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..59
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..88
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 89..151
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 152..178
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 179..238
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..268
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 269..277
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT LIPID 6
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 7
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 10
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 109
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 139
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 141
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 199
FT /note="O-palmitoyl threonine"
FT /evidence="ECO:0000250"
FT DISULFID 184..228
FT /evidence="ECO:0000250"
FT DISULFID 201..220
FT /evidence="ECO:0000250"
SQ SEQUENCE 277 AA; 30123 MW; 0688D425A8615FCF CRC64;
MGLLECCARC LIGAPFASLV ATGLCFFGVA LFCGCGHEAL TGTEQLIETY FSKNYQDYEY
LIDVIHAFQY VIYGTASFFF LYGALLLAEG FYTTGAVRQI FGDYRTTICG KGLSATVTGG
PKGRGARGPQ RAHSLQRVCQ CLGKWLGHPD KFVGITYVLT IVWLLAFACS AVPVYIYFNT
WTTCQSIAFP TKTTASIGTL CADARMYGVL PWNAFPGKVC GSNLLSICKT SEFQMTFHLF
IAAFVGAAAT LVSLLTFMIA ATYNFAVLKL MGRGTKF
