ID   A15_VARV                Reviewed;          94 AA.
AC   P0DOO8; P33840;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   29-SEP-2021, entry version 10.
DE   RecName: Full=Core protein A15;
GN   ORFNames=A15L, A16L;
OS   Variola virus.
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=10255;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Bangladesh-1975;
RX   PubMed=8264798; DOI=10.1038/366748a0;
RA   Massung R.F., Esposito J.J., Liu L.I., Qi J., Utterback T.R., Knight J.C.,
RA   Aubin L., Yuran T.E., Parsons J.M., Loparev V.N., Selivanov N.A.,
RA   Cavallaro K.F., Kerlavage A.R., Mahy B.W.J., Venter J.C.;
RT   "Potential virulence determinants in terminal regions of variola smallpox
RT   virus genome.";
RL   Nature 366:748-751(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Garcia-1966;
RA   Shchelkunov S.N., Totmenin A.V., Sosnovtsev S.V., Safronov P.F.,
RA   Resenchuk S.M., Blinov V.M., Sandakhchiev L.S.;
RT   "XhoI-D DNA fragment of Variola minor virus strain Garcia-1966.";
RL   Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Late protein which is a part of a large complex required for
CC       early virion morphogenesis. This complex participates in the formation
CC       of virosomes and the incorporation of virosomal contents into nascent
CC       immature virions. A15 is required for the stability and kinase activity
CC       of F10 (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Part of a complex composed of A30, G7, F10 kinase, A15, D2,
CC       D3, and J1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Virion.
CC       Note=Localizes in cytoplasmic virus factories and present in the virion
CC       core. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the chordopoxvirinae A15 family. {ECO:0000305}.
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DR   EMBL; L22579; AAA60867.1; -; Genomic_DNA.
DR   EMBL; X76268; CAA53888.1; -; Genomic_DNA.
DR   PIR; E72165; E72165.
DR   PIR; T28557; T28557.
DR   RefSeq; NP_042163.1; NC_001611.1.
DR   GeneID; 1486490; -.
DR   KEGG; vg:1486490; -.
DR   Proteomes; UP000119805; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008445; A15.
DR   Pfam; PF05846; Chordopox_A15; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Late protein; Virion.
FT   CHAIN           1..94
FT                   /note="Core protein A15"
FT                   /id="PRO_0000448154"
SQ   SEQUENCE   94 AA;  10951 MW;  7A56E89226C2D3F3 CRC64;
     MFVDDDSLII YSTWPSTLSD SSGRVIVMPD NRSFTFKEGF KLDESIKSIL LVNPSSIDLL
     KIRVYKHRIK WMGNIFVLFE QENIPPPFRL VNDK