ID   MYSC_CHICK              Reviewed;        1102 AA.
AC   P29616;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-APR-1993, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Myosin heavy chain, cardiac muscle isoform;
DE   Flags: Fragment;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 65-1102.
RC   STRAIN=Broiler; TISSUE=Heart;
RX   PubMed=1774788; DOI=10.1007/bf02102866;
RA   Stewart A.F.R., Camoretti-Mercado B., Perlman D., Gupta M., Jakovcic S.,
RA   Zak R.;
RT   "Structural and phylogenetic analysis of the chicken ventricular myosin
RT   heavy chain rod.";
RL   J. Mol. Evol. 33:357-366(1991).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-259.
RC   TISSUE=Heart;
RX   PubMed=1418675; DOI=10.1515/bchm3.1992.373.2.1045;
RA   Watanabe B.;
RT   "Amino-acid sequence of the short subfragment-2 in adult chicken cardiac
RT   muscle myosin.";
RL   Biol. Chem. Hoppe-Seyler 373:1045-1054(1992).
CC   -!- FUNCTION: Muscle contraction.
CC   -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC       chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC       regulatory light chain subunits (MLC-2).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- TISSUE SPECIFICITY: Ventricular muscle and traces levels in the atrium.
CC       Also transient expression in skeletal muscle during fetal development
CC       and regeneration following freeze injury.
CC   -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles
CC       of a 28-residue repeat pattern composed of 4 heptapeptides,
CC       characteristic for alpha-helical coiled coils.
CC   -!- DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light
CC       meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further
CC       cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment
CC       (S2). {ECO:0000305}.
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DR   EMBL; X59552; CAA42130.1; -; mRNA.
DR   AlphaFoldDB; P29616; -.
DR   SMR; P29616; -.
DR   STRING; 9031.ENSGALP00000036100; -.
DR   PaxDb; P29616; -.
DR   PRIDE; P29616; -.
DR   VEuPathDB; HostDB:geneid_395534; -.
DR   eggNOG; KOG0161; Eukaryota.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005814; C:centriole; IBA:GO_Central.
DR   GO; GO:0005813; C:centrosome; IBA:GO_Central.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0055014; P:atrial cardiac muscle cell development; IMP:AgBase.
DR   GO; GO:0009792; P:embryo development ending in birth or egg hatching; IEP:AgBase.
DR   Gene3D; 1.20.5.370; -; 5.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   1: Evidence at protein level;
KW   Actin-binding; ATP-binding; Coiled coil; Cytoplasm;
KW   Direct protein sequencing; Motor protein; Muscle protein; Myosin;
KW   Nucleotide-binding; Reference proteome; Thick filament.
FT   CHAIN           <1..1102
FT                   /note="Myosin heavy chain, cardiac muscle isoform"
FT                   /id="PRO_0000123436"
FT   REGION          1070..1102
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          <1..1102
FT                   /evidence="ECO:0000255"
FT   CONFLICT        65
FT                   /note="A -> T (in Ref. 1; CAA42130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        92
FT                   /note="V -> A (in Ref. 1; CAA42130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        113..114
FT                   /note="CS -> FAL (in Ref. 1; CAA42130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        135
FT                   /note="H -> Q (in Ref. 1; CAA42130)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        185
FT                   /note="T -> R (in Ref. 1; CAA42130)"
FT                   /evidence="ECO:0000305"
FT   NON_TER         1
SQ   SEQUENCE   1102 AA;  128009 MW;  2293668D049825DC CRC64;
     KIKPLLKSAE TEKEMANMKE EFLKLKEALE KSEARRKELE EKQVSLVQEK NDLLLQLQAE
     QDTLADAEER CDLLIKSKIQ LEAKVKELTE RVEDEEEMNS ELTSKKRKLE DECSELKKDI
     DDLEITLAKV EKEKHATENK VKNLTEEMAT LDENISKLTK EKKSLQEAHQ QVLDDLQAEE
     DKVNTLSKAK VKLEQQVDDL EGSLEQEKKV RMDLERAKRK LEGDLKLTQE SVMDLENDKL
     QMEEKLKKKE FEMSQLNSKI EDEQAIVMQL QKKIKELQAR IEELEEELEA ERAARAKVEK
     QRSDLARELE ELSERLEGAG GATAAQLEMN KKREAEFLKL ARDLEEATLH YEATAAALRK
     KHADRRGEMG EQLDNLQRVK QKLEKEKSEL KMEVDDLTAN MEQTVKGKAN AEKLWGTYED
     HLNETKTKLD EMTRLMNDLT TQKTKLQSEN GEFVRQLEEK ESLISQLSRG KTSFTQQIEE
     LRRQLEEETK SKNALAHALQ AARHDCDLLR EQYEEEQEAK AELQRALSKG NAEVAQWRTK
     YETDAIQRTE ELEDAKKKLL ARLQEAEEAI EAANAKCSSL EKAKHRLQNE QEDMMIDLEK
     ANSAAASLDK KQRGFDKIIN DWKQKYEESQ AELEASQKEA RSLSTELFKL KNAYEETLDH
     LETLKRENKN LQEEISDLTN QISEGNKNLH EIEKVKKQVE QEKSEVQLAL EEAEGALEHE
     ESKTLRFQLE LSQLKADFER KLAEKDEEMQ NIRRNQQRTI DSLQSTLDSE ARSRNEAIRL
     KKKMEGDLNE MEIQLSHANR HAAEATKSAR GLQTQIKELQ VQLDDLGHLN EDLKEQLAVS
     DRRNNLLQSE LDELRALLDQ TERARKLAEH ELLEATERVN LLHTQNTSLI NQKKKLEGDI
     SQMQNEVEES IQECRNAEQK AKKAITDAAM MAEELKKEQD TSAHLERMKK NMEQTIKDLQ
     KRLDEAEQIA LKGGKKQIQK LESRVRELEN ELENELRRNS DAQKGARKFE RRIKELTYQS
     EEDKKNLARM QDLIDKLQLK VKSYKHQAEE AEAQANLYLS KYRKQQHDLD DAEERAEIAE
     SQVDKLRSKS RDIGMKKVDA EE