ID   AROC1_SOLLC             Reviewed;         440 AA.
AC   Q42884;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Chorismate synthase 1, chloroplastic;
DE            EC=4.2.3.5;
DE   AltName: Full=5-enolpyruvylshikimate-3-phosphate phospholyase 1;
DE   Flags: Precursor;
GN   Name=CS1;
OS   Solanum lycopersicum (Tomato) (Lycopersicon esculentum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum;
OC   Solanum subgen. Lycopersicon.
OX   NCBI_TaxID=4081;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. UC82B;
RX   PubMed=8251624; DOI=10.1007/bf00021526;
RA   Goerlach J., Schmid J., Amrheim N.;
RT   "Differential expression of tomato (Lycopersicon esculentum L.) genes
RT   encoding shikimate pathway isoenzymes. II. Chorismate synthase.";
RL   Plant Mol. Biol. 23:707-716(1993).
CC   -!- FUNCTION: Catalyzes the last common step of the biosynthesis of
CC       aromatic amino acids, produced via the shikimic acid pathway.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate +
CC         phosphate; Xref=Rhea:RHEA:21020, ChEBI:CHEBI:29748,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:57701; EC=4.2.3.5;
CC   -!- COFACTOR:
CC       Name=FMNH2; Xref=ChEBI:CHEBI:57618;
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       7/7.
CC   -!- SUBUNIT: Homotetramer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Plastid, chloroplast.
CC   -!- TISSUE SPECIFICITY: Predominantly expressed in flowers and roots and,
CC       to a lesser extent, in stems, leaves, and cotyledons.
CC   -!- SIMILARITY: Belongs to the chorismate synthase family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z21796; CAA79859.1; -; mRNA.
DR   PIR; S40410; S40410.
DR   RefSeq; NP_001234422.1; NM_001247493.2.
DR   AlphaFoldDB; Q42884; -.
DR   SMR; Q42884; -.
DR   STRING; 4081.Solyc04g049350.2.1; -.
DR   PaxDb; Q42884; -.
DR   PRIDE; Q42884; -.
DR   GeneID; 544154; -.
DR   KEGG; sly:544154; -.
DR   eggNOG; KOG4492; Eukaryota.
DR   HOGENOM; CLU_034547_0_1_1; -.
DR   InParanoid; Q42884; -.
DR   OrthoDB; 826475at2759; -.
DR   PhylomeDB; Q42884; -.
DR   UniPathway; UPA00053; UER00090.
DR   Proteomes; UP000004994; Unplaced.
DR   GO; GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004107; F:chorismate synthase activity; IBA:GO_Central.
DR   GO; GO:0010181; F:FMN binding; IBA:GO_Central.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IBA:GO_Central.
DR   GO; GO:0008652; P:cellular amino acid biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IBA:GO_Central.
DR   CDD; cd07304; Chorismate_synthase; 1.
DR   Gene3D; 3.60.150.10; -; 1.
DR   HAMAP; MF_00300; Chorismate_synth; 1.
DR   InterPro; IPR000453; Chorismate_synth.
DR   InterPro; IPR035904; Chorismate_synth_AroC_sf.
DR   InterPro; IPR020541; Chorismate_synthase_CS.
DR   PANTHER; PTHR21085; PTHR21085; 1.
DR   Pfam; PF01264; Chorismate_synt; 1.
DR   SUPFAM; SSF103263; SSF103263; 1.
DR   TIGRFAMs; TIGR00033; aroC; 1.
DR   PROSITE; PS00787; CHORISMATE_SYNTHASE_1; 1.
DR   PROSITE; PS00788; CHORISMATE_SYNTHASE_2; 1.
DR   PROSITE; PS00789; CHORISMATE_SYNTHASE_3; 1.
PE   2: Evidence at transcript level;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis; Chloroplast;
KW   Lyase; Plastid; Reference proteome; Transit peptide.
FT   TRANSIT         1..54
FT                   /note="Chloroplast"
FT                   /evidence="ECO:0000255"
FT   CHAIN           55..440
FT                   /note="Chorismate synthase 1, chloroplastic"
FT                   /id="PRO_0000002296"
FT   REGION          100..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        100..114
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        115..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  47722 MW;  A4AFE9F410E2EAFA CRC64;
     MASFVPTKQF VGASSSSDIG SSRLVSLQLP SKFSSSNFHL PSRPSQLKRL EIQAAGSTFG
     NYFRVTTFGE SHGGGVGCII DGCPPRLPLS ESDMQVELDR RRPGQSRITT PRKETDTCKI
     SSGTADGLTT GSPIKVEVPN TDQRGNDYSE MSLAYRPSHA DATYDFKYGV RSVQGGGRSS
     ARETIGRVAA GAVAKKILKL YSGAEVLAYV SQVHQVVLPE DLIDHQNVTL EQIESNIVRC
     PDPEYAEKMI AAIDAVRVRG DSVGGVVTCI VRNLPRGLGT PVFDKLEAEL AKACMSLPAT
     KGFEFGSGFA GTFMTGSEHN DEFYMDEHGR IRTRTNRSGG IQGGISNGEV INMRIGFKPT
     STISRKQQTV TRDKHETELI ARGRHDPCVV PRAVPMVEAM VALVLVDQLM AQYSQCMMFP
     INPELQEPLQ SSPESAEVTL