ID   MYSP_BLOTA              Reviewed;         875 AA.
AC   Q8MUF6;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Paramyosin;
DE   AltName: Allergen=Blo t 11;
OS   Blomia tropicalis (Mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Glycyphagoidea; Echimyopodidae;
OC   Blomia.
OX   NCBI_TaxID=40697;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=11815735; DOI=10.1159/000049525;
RA   Ramos J.D., Cheong N., Lee B.W., Chua K.Y., Nge C., Wah L.B., Yan C.K.;
RT   "cDNA cloning and expression of Blo t 11, the Blomia tropicalis allergen
RT   homologous to paramyosin.";
RL   Int. Arch. Allergy Immunol. 126:286-293(2001).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; AF525465; AAM83103.1; -; mRNA.
DR   AlphaFoldDB; Q8MUF6; -.
DR   SMR; Q8MUF6; -.
DR   Allergome; 148; Blo t 11.
DR   Allergome; 3148; Blo t 11.0101.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Cytoplasm; Motor protein; Muscle protein; Myosin;
KW   Thick filament.
FT   CHAIN           1..875
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211243"
FT   REGION          1..28
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          110..143
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          855..874
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          29..854
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   875 AA;  102028 MW;  EF7009B071949CA0 CRC64;
     MAARSAKYMY QSSRAGHGGD ISIEYGTDLG ALTRLEDKIR LLSEDLESER ELRQRVEREK
     SDITVQLMNL TERLEETEGS SESVTEMNKK RDSELAKLRK LLEDVHMESE ETAHHLRQKH
     QAAIQEMQDQ LDQVQKAKNK SDKEKQKFQA EVFELLAQVE TANKDKLVAQ KTVEKLEYTV
     HELNIKIEEI NRTVVEVTAH RQRLSQENSE LIKEVHEYKI SLDNANHLKG QIAQQLEDTR
     HRLEDEERKR SSLENHAHTL EVELESLKVQ LEEESEARLE LERQLTKANG DAASWKSKYE
     AELQAHVDEV EELRRKMAQK ISEYGEQLEA LLNKCSALEK QKARLQSEVE VLIMDLEKAT
     AHAQALEKRV SQLEKINLDL KSKLEEVSML LEQTQKDLRV KIADLQKLQH EYEKLRDQKE
     ALARENKKLA DDLAEAKSQL NDAHRRIHEQ EIEIKRLENE REELAAAYKE AETLRKQEEA
     KNQRLTAELA QTRHDYEKRL AQKEEEIEAL RKQYQIEIEQ LNMRLAEAEA KLKTEVARLK
     KKYQAQITEL ELSLDAANKA NIDLQKTIKK QALQITGLQA HYDEVHRQLQ QAVDQLGVTQ
     RRCQALTAEL EEMRVNLEQA LRAKRAAEQM HEEAVVRVNE LTTINVNLAS AKSKLETEFS
     ALQNDYDEVH KELRISDERV QKLTIEVKST KDLLESETER VTKLETIKKS LETEVRNLQI
     RIEEVEANAL AGGKRVIAKL ESRIRDVEIE VEEERRRHAE TEKMLRKKDH RVKELLLQNE
     EDHKQIQLLQ EMSDKLNEKV KVYKRQMQEQ EGMSQQNLTR VRRFQRELEA AEDRADQAES
     NLSFIRAKHR SWVTTSQVPG GTRQVFVTEQ ESSNF