ID   MYSP_BRUMA              Reviewed;         880 AA.
AC   Q01202; P90711;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Paramyosin;
OS   Brugia malayi (Filarial nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=6279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Langy S., Luquiaud P., Nicolas L.;
RL   Submitted (NOV-1996) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 180-263 AND 684-880.
RX   PubMed=1775173; DOI=10.1016/0166-6851(91)90075-h;
RA   Li B., Chandrashekar R., Alvarez R.M., Liftis F., Weil G.J.;
RT   "Identification of paramyosin as a potential protective antigen against
RT   Brugia malayi infection in jirds.";
RL   Mol. Biochem. Parasitol. 49:315-324(1991).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; U77590; AAC18613.1; -; mRNA.
DR   EMBL; M63097; AAA27859.1; -; mRNA.
DR   EMBL; M63098; AAA27860.1; -; mRNA.
DR   AlphaFoldDB; Q01202; -.
DR   SMR; Q01202; -.
DR   STRING; 6279.Q01202; -.
DR   PRIDE; Q01202; -.
DR   Proteomes; UP000006672; Unassembled WGS sequence.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Motor protein; Muscle protein; Myosin;
KW   Reference proteome; Thick filament.
FT   CHAIN           1..880
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211245"
FT   REGION          1..34
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          860..880
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          35..859
FT                   /evidence="ECO:0000255"
FT   CONFLICT        189
FT                   /note="V -> I (in Ref. 2; AAA27859)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        197
FT                   /note="D -> A (in Ref. 2; AAA27859)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        251
FT                   /note="L -> F (in Ref. 2; AAA27859)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        255
FT                   /note="E -> Q (in Ref. 2; AAA27859)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        696
FT                   /note="A -> R (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        730..736
FT                   /note="FRKLKRR -> IQEAETAA (in Ref. 2; AAA27860)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        825
FT                   /note="L -> LQ (in Ref. 2; AAA27860)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        857..880
FT                   /note="HQLLRAKMLQRQKFTFSKMSNRDN -> SSVVTGKNASASKIYVLEDEQ
FT                   (in Ref. 2; AAA27860)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   880 AA;  101904 MW;  F79A27E642D4A85E CRC64;
     MSGSLYRSPS AALYKSPSMS AFGGLPAAFG SMSVADLGSL TRLEDKIRLL QEDLESAREL
     RNRIERERAD LSVQLIALTD RLEDAEGTTD SQIESNRKRE AELQKLRKLL EESQLENEDA
     MNILRKKHQD ACLDYAEQIE QLQKKNSKID RERQRLQHEV IELTATIDQL KKDKHLAEKA
     AERFEAQTVE LSNKVEDLNR HVNDLAQQRQ RLQAENNDLL KEIHDQKVQL DNLQHVKYQL
     AQQLEEARRR LEDAERERSQ LQAQLHQVQL ELDSVRTALD EESAARAEAE HKLALANTEI
     TQWKSKFDAE VALHHEEVED LRKKMLQKQA EYEEQIEIML QKISQLEKAK SRLQSEVEVL
     IVDLEKAQNT IAILERAKEQ LEKTVNELKV RIDELTVELE AAQREARAAL AELQKLKNLY
     EKAVEQKEAL ARENKKLQDD LHEAKEALAD ANRKLHELDL ENARLAGEIR ELQTALKESE
     AARRDAENRA QRALAELQQL RIEMERRLQE KEEEMEALRK NMQFEIDRLT AALADAEARM
     KAEISRLKKK YQAEIAELEM TVDNLNRANI EAQKTIKKQS EQLKILQASL EDTQRQLQQT
     LDQYALAQRK VSALSAELEE CKVALDNAIR ARKQAEIDLE EANGRITDLV SVNNNLTAIK
     NKLETELSTA QADLDEATKE LHAADERANR ALADAARAVE QLHEEQEHSM KIDALRKSLE
     EQVKQLQVQF RKLKRRLLGG KRVIAKLETR IRDLETALDE ETRRHKETQG ALRKKDRRIK
     EVQMQVDEEH KMFVMAQDTA DRLLEKLNIQ KRQLGEAESL TMANLRVRRY QRELEDAEGR
     ADQAESSLHL IRAKHRHQLL RAKMLQRQKF TFSKMSNRDN