ID   MYSP_DERFA              Reviewed;         692 AA.
AC   Q967Z0;
DT   16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Paramyosin;
DE   AltName: Full=Antigen Df642;
DE   AltName: Allergen=Der f 11;
DE   Flags: Fragment;
OS   Dermatophagoides farinae (American house dust mite).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari;
OC   Acariformes; Sarcoptiformes; Astigmata; Psoroptidia; Analgoidea;
OC   Pyroglyphidae; Dermatophagoidinae; Dermatophagoides.
OX   NCBI_TaxID=6954;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=10594536; DOI=10.1046/j.1365-2222.1999.00603.x;
RA   Tsai L.-C., Sun Y., Chao P.-L., Ng H.-P., Hung M., Hsieh K., Liaw S.,
RA   Chua K.-Y.;
RT   "Sequence analysis and expression of a cDNA clone encoding a 98-kDa
RT   allergen in Dermatophagoides farinae.";
RL   Clin. Exp. Allergy 29:1606-1613(1999).
RN   [2]
RP   PARTIAL PROTEIN SEQUENCE, AND CHARACTERIZATION.
RX   PubMed=9723675; DOI=10.1016/s0091-6749(98)70099-5;
RA   Tsai L.-C., Chao P.-L., Shen H.D., Tang R.B., Chang T.C., Chang Z.N.,
RA   Hung M.W., Lee B.L., Chua K.-Y.;
RT   "Isolation and characterization of a novel 98-kd Dermatophagoides farinae
RT   mite allergen.";
RL   J. Allergy Clin. Immunol. 102:295-303(1998).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- ALLERGEN: Causes an allergic reaction in human. Binds to IgE.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; AF352244; AAK39511.1; -; mRNA.
DR   AlphaFoldDB; Q967Z0; -.
DR   SMR; Q967Z0; -.
DR   Allergome; 297; Der f 11.
DR   Allergome; 3249; Der f 11.0101.
DR   PRIDE; Q967Z0; -.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 2.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   1: Evidence at protein level;
KW   Allergen; Coiled coil; Cytoplasm; Direct protein sequencing; Motor protein;
KW   Muscle protein; Myosin; Thick filament.
FT   CHAIN           1..>692
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211247"
FT   REGION          1..15
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          26..57
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          16..>692
FT                   /evidence="ECO:0000255"
FT   NON_TER         692
SQ   SEQUENCE   692 AA;  81372 MW;  61FC6380C9D7C9E2 CRC64;
     MNKKRDSELA KLRKLLEDVH IESEETAHHL RQKHQAAIQE MQDQLDQLQK AKNKSDKEKQ
     KFQAEVFELL AQLETANKEK LTALKNVEKL EYTVHELNIK IEEINRTVIE LTSHKQRLSQ
     ENTELIKEVH EVKLQLDNAN HLKTQIAQQL EDTRHRLEEE ERKRASLENH AHTLEVELES
     LKVQLDEESE ARLELERQLT KANGDAASWK SKYEAELQAH ADEVEELRRK MAQKISEYEE
     QLEALLNKCS SLEKQKSRLQ SEVEVLIMDL EKATRHAQQL EKRVAQLEKI NLDLKNKLEE
     VTMLMEQAQK ELRVKIAELQ KLQHEYEKLR DQRDQLAREN KKLTDDLAEA KSQLNDAHRR
     IHEQEIEIKR LENERDELSA AYKEAETLRK QEEAKNQRLI AELAQVRHDY EKRLAQKDEE
     IEALRKQYQI EIEQLNMRLA EAEAKLKTEI ARLKKKYQAQ ITELELSLDA ANKANIDLQK
     TIKKQALQIT ELQAHYDEVH RQLQQAVDQL GVTQRRCQAL QAELEEMRIA LEQANRAKRQ
     AEQLHEEAVV RVNELTTINV NLASAKSKLE SEFSALQADY DEVHKELRIS DERVQKLTIE
     LKSTKDLLIE EQERLVKLET VKKSLEQEVR TLHVRIEEVE ANALAGGKRV IAKLESRIRD
     VEIEVEEERR RHAETDKMLR KKDHRVKELL LQ