ID   MYSP_DIRIM              Reviewed;         848 AA.
AC   P13392;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Paramyosin;
DE   Flags: Fragment;
OS   Dirofilaria immitis (Canine heartworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Dirofilaria.
OX   NCBI_TaxID=6287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2325708; DOI=10.1016/0166-6851(90)90030-p;
RA   Limberger R.J., McReynolds L.A.;
RT   "Filarial paramyosin: cDNA sequences from Dirofilaria immitis and
RT   Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 38:271-280(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-96.
RX   PubMed=2527335; DOI=10.1016/0166-6851(89)90139-4;
RA   Grandea A.G. III, Tuyen L.K., Asikin N., Davis T.B., Philipp M., Cohen C.,
RA   McReynolds L.A.;
RT   "A lambda gt11 cDNA recombinant that encodes Dirofilaria immitis
RT   paramyosin.";
RL   Mol. Biochem. Parasitol. 35:31-41(1989).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; M29733; AAA28299.1; -; mRNA.
DR   EMBL; J04009; AAA28300.1; -; mRNA.
DR   PIR; A44972; A44972.
DR   PIR; A45548; A45548.
DR   AlphaFoldDB; P13392; -.
DR   SMR; P13392; -.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Disulfide bond; Motor protein; Muscle protein;
KW   Myosin; Thick filament.
FT   CHAIN           <1..>848
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211248"
FT   REGION          <1..9
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          834..848
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          10..833
FT                   /evidence="ECO:0000255"
FT   DISULFID        105
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255"
FT   DISULFID        594
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255"
FT   NON_TER         1
FT   NON_TER         848
SQ   SEQUENCE   848 AA;  98008 MW;  BF32B7120157FA50 CRC64;
     AFGSMSVADL GSLTRLEDKI RLLQEDLESE RELRNRIERE RADLSVQLIA LTDRLEDAEG
     TTDSQIESNR KREAELQKLR KLLEESQLEN EDAMNVLRKK HQDACLDYAE QIEQLQKKNS
     KIDRERQRLQ HEVIELTATI DQLQKDKHLA EKAAERFEAQ TIELSNKVED LNRHVNDLAQ
     QRQRLQAENN DLLKEIHDQK VQLDNLQHVK YQLAQQLEEA RRRLEDAERE RSQLQAQLHQ
     VQLELDSVRT ALDEESAARA EAEHKLALAN TEITQWKSKF DAEVALHHEE VEDLRKKMLQ
     KQAEYEEQIE IMLQKISQLE KAKSRLQSEV EVLIVDLEKA QNTIAILERA KEQLEKTVNE
     LKVRIDELTV ELEAAQREAR AALAELQKMK NLYEKAIEQK EALARENKKL QDDLHEAKEA
     LADANRKLHE LDLENARLAG EIRELQTALK ESEAARRDAE NRAQRALAEL QQLRIEMERR
     LQEKEEEMEA LRKNMQFEID RLTAALADAE ARMKAEISRL KKKYQAEIAE LEMTVDNLNR
     ANIEAQKTIK KQSEQLKILQ ASLEDTQRQL QQTLDQYALA QRKVSALSAE LEECKVALDN
     AIRARKQAEI DLEEANARIT DLVSINNNLT AIKNKLETEL STAQADLDEA TKELHAADER
     ANRALADAAR AVEQLHEEQE HSMKIDALRK SLEEQVKQLQ VQIQEAEAAA LLGGKRVIAK
     LETRIRDLET ALDEETRRHK ETQGALRKKD RRIKEVQMQV DEEHKMFVMA QDTADRLLEK
     LNIQKWQLGE AESLTMANLQ RVRRYQRELE DAEGRADQAE SSLHLIRAKH RSSVVTGKNA
     SASKIYVL