ID   MYSP_ONCVO              Reviewed;         879 AA.
AC   Q02171; Q25629;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Paramyosin;
OS   Onchocerca volvulus.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Onchocerca.
OX   NCBI_TaxID=6282;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=7679477; DOI=10.1016/0166-6851(93)90209-g;
RA   Dahmen A., Gallin M., Schumacher M., Erttmann K.D.;
RT   "Molecular cloning and pre-mRNA maturation of Onchocerca volvulus
RT   paramyosin.";
RL   Mol. Biochem. Parasitol. 57:335-338(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 310-367.
RX   PubMed=2325708; DOI=10.1016/0166-6851(90)90030-p;
RA   Limberger R.J., McReynolds L.A.;
RT   "Filarial paramyosin: cDNA sequences from Dirofilaria immitis and
RT   Onchocerca volvulus.";
RL   Mol. Biochem. Parasitol. 38:271-280(1990).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; M95813; AAA29431.1; -; mRNA.
DR   EMBL; M29736; AAA29426.1; -; mRNA.
DR   PIR; A48575; A48575.
DR   AlphaFoldDB; Q02171; -.
DR   SMR; Q02171; -.
DR   STRING; 6282.Q02171; -.
DR   PRIDE; Q02171; -.
DR   HOGENOM; CLU_000192_13_6_1; -.
DR   Proteomes; UP000024404; Unassembled WGS sequence.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Motor protein; Muscle protein; Myosin;
KW   Reference proteome; Thick filament.
FT   CHAIN           1..879
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211253"
FT   REGION          1..36
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          837..879
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          861..879
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          37..860
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        837..854
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        310
FT                   /note="E -> K (in Ref. 2; AAA29426)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   879 AA;  101126 MW;  DCA24AC01A9F02B1 CRC64;
     MSGSLYRSPS AALYKSPSMS AFSGLPAAFG SMSVADLGSL TRLEDKIRLL QEDLESEREL
     RNRIERERAD LSVQLIALTD RLEDAEGTTD SQIESNRKRE AELQKLRKLL EESQLENEDA
     MNVLRKKHQD ACLDYTEQIE QLQKKNSKID RERQRLQHEV IELTAAIDQL QKDKHLAEKA
     AERFEAQTIE LSNKVEDLNR HVNDLAQQRQ RLQAENNDLL KEIHDQKVQL DNLQHVKYQL
     AQQLEEARRR LEDAERERSQ LQAQLHQVQL ELDSVRTALD EESAARAEAE HKLALANTEI
     TQWKSKFDAE VALHHEEVED LRKKMLQKQA EYEEQIEIML QKISQLEKAK SRLQSEVEVL
     IVDLEKAQNT IAILERAKEQ LEKTVNELKV RIDELTVELE AAQREARAAL AELQKMKNLY
     EKAVEQKEAL ARENKKLQDD LHEAKEALAD ANRKLHELDL ENARLAGEIR ELQTALKESE
     AARRDAENRA QRALAELQQL RIEMERRLQE KEEEMEALRK NMQFEIDRLT AALADAEARM
     KAEIARLKKK YQAEIAELEM TVDNLNRANI EAQKTIKKQS EQLKVLQASL EDTQRQLQQT
     LDQYALAQRK VSALSAELEE CKVALDNAIR ARKQAEIDLE EANGRITDLV SINNNLTAIK
     NKLETELSTA QADLDEATKE LHAADERANR ALADAARAVE QLHEEQEHSM KIDALRKSLE
     EQVKQLQVQI QEAEAAALLG GKRVIAKLET RIRDLETALD EETRRHKETQ GALRKKDRRI
     KEVQMQVDEE HKMFVMAQDT ADRLLEKLNI QKRQLGEAES LTMANLQRVR RYQRELEDAE
     GRADQAESSL HLIRAKHRSS VTAGKNASAS KIYVLEDDQ