ID   MYSP_SCHJA              Reviewed;         866 AA.
AC   Q05870; Q26510; Q26518; Q9UAS3;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Paramyosin;
DE   AltName: Full=Antigen Sj97;
OS   Schistosoma japonicum (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6182;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Philippines;
RX   PubMed=7676905; DOI=10.1016/0001-706x(94)00090-n;
RA   Becker M.M., Kalinna B.H., Yang W., Harrop S.A., Scott J.C., Waine G.J.,
RA   Kurtis J.D., McManus D.P.;
RT   "Gene cloning and complete nucleotide sequence of Philippine Schistosoma
RT   japonicum paramyosin.";
RL   Acta Trop. 59:143-147(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Japanese;
RX   PubMed=7947464; DOI=10.1093/intimm/6.7.963;
RA   Nara T., Matsumoto N., Janecharut T., Matsuda H., Yamamoto K., Iimura T.,
RA   Nakamura K.I., Aikawa M., Oswald I., Sher A., Kita K., Kojima S.;
RT   "Demonstration of the target molecule of a protective IgE antibody in
RT   secretory glands of Schistosoma japonicum larvae.";
RL   Int. Immunol. 6:963-971(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Chinese;
RA   Zhou S.-H., Liu S.-X., Song G.-C., Xu Y.-X., Sun W.;
RT   "Protective immunity induced by the full-length cDNA encoding paramyosin of
RT   Chinese Schistosoma japonicum.";
RL   Vaccine 15:3196-3204(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 171-559.
RX   PubMed=1487380; DOI=10.1016/0020-7519(92)90041-i;
RA   Yang W., Waine G.J., Sculley D.G., Liu X., McManus D.P.;
RT   "Cloning and partial nucleotide sequence of Schistosoma japonicum
RT   paramyosin: a potential vaccine candidate against schistosomiasis.";
RL   Int. J. Parasitol. 22:1187-1191(1992).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- DEVELOPMENTAL STAGE: May be incorporated into the tegument during the
CC       development of schistosomula, thus becoming a target for protective
CC       immunity during the migratory phase of the parasite.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; U11825; AAA81003.1; -; mRNA.
DR   EMBL; D28811; BAA05972.1; -; mRNA.
DR   EMBL; AF113971; AAD29285.1; -; mRNA.
DR   EMBL; M90492; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q05870; -.
DR   SMR; Q05870; -.
DR   PRIDE; Q05870; -.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Disulfide bond; Motor protein; Muscle protein;
KW   Myosin; Thick filament.
FT   CHAIN           1..866
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211256"
FT   REGION          1..22
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          840..866
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          23..839
FT                   /evidence="ECO:0000255"
FT   DISULFID        750
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255"
FT   VARIANT         567
FT                   /note="V -> I (in strain: Chinese)"
FT   VARIANT         720
FT                   /note="F -> Y (in strain: Chinese)"
FT   CONFLICT        371
FT                   /note="E -> D (in Ref. 1; AAA81003)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        559
FT                   /note="E -> K (in Ref. 4)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   866 AA;  100542 MW;  37D7BDF2CF32775D CRC64;
     MMNHDTESHV KISRTIYRGV SPSTTRLESR VRELEDILDL ERDARVRAER HAADLSYQVD
     ALSERLDEAG GSTTQTQELL KRREMEINKL RKDLENANAS LELAETSMRR RHQTALNELS
     LEVENLQKQK GKAEKDKSHL IMEVDNVLGQ LDGALKAKQS AESKLEGLDS QLNRLKTLTD
     DLQRQLTELN NAKSRLTSEN FELLHINQDY EAQILNYSKA KSSLESQVDD LKRSLDDESR
     NRFNLQAQLT SLQMDYDNLQ AKYDEESEEA SNLRNQVSKF NADIAALKSK FERELMSKTE
     EFEEMKRKLT MRITELEDVA ERERLKAVSL EKLKTKLTLE IKDLQSEIES LSLENGELIR
     RAKSAESLAS ELQRRVDELT IEVNTLTSQN NQLESENMRL KSLVNDLTDK NNALERENRQ
     MNDQVKELKS SLRDANRRLT DLEALRSQLE AERDNLASAL HDAEEALRDM DQKYQASQAA
     LNHLKSEMEQ RLRERDEELE SLRKSTTRTI EELTVTITEM EVKYKSELSR LKKRYESSIA
     DLEIQLDATN KANANLMKEN KNLAQRVKDL ETFLDDERRL REAAENNLQI TEHKRIQLAN
     EVEELRSAME NLERLRKHAE TELEETQSRV SELTIQVNTL SNDKRRLEGD IGVMQADMDD
     AINAKQAAED RATRLNNEVL RLADELRQEQ ENYKHAEALR KQLEIEIREI TVKLEEAEAF
     ATREGRRMVQ KLQARVRELE AEFDGESRRC KDALAQARKF ERQYKELQTQ AEDDRRMVLE
     LQDLLDKTQM KMKAYKRQLE EMEEVSQITM NKYRKAQQQI EEAEHRADMA ERTVTVRRVG
     PGGRAVSVAR ELSVTSNRGM RATSMM