ID   MYSP_SCHMA              Reviewed;         866 AA.
AC   P06198;
DT   01-JAN-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 2.
DT   25-MAY-2022, entry version 91.
DE   RecName: Full=Paramyosin;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2052029; DOI=10.1016/0166-6851(91)90015-x;
RA   Laclette J.P., Landa A., Arcos L., Willms K., Davis A.E., Shoemaker C.B.;
RT   "Paramyosin is the Schistosoma mansoni (Trematoda) homologue of antigen B
RT   from Taenia solium (Cestoda).";
RL   Mol. Biochem. Parasitol. 44:287-296(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 303-742.
RX   PubMed=3094144; DOI=10.1126/science.3094144;
RA   Lanar D.E., Pearce E.J., James S.L., Sher A.;
RT   "Identification of paramyosin as schistosome antigen recognized by
RT   intradermally vaccinated mice.";
RL   Science 234:593-596(1986).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; M35499; AAA29915.1; -; mRNA.
DR   EMBL; M14163; AAA29914.1; -; mRNA.
DR   PIR; A60608; A60608.
DR   AlphaFoldDB; P06198; -.
DR   SMR; P06198; -.
DR   PRIDE; P06198; -.
DR   eggNOG; KOG0161; Eukaryota.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   InterPro; IPR002928; Myosin_tail.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Disulfide bond; Motor protein; Muscle protein;
KW   Myosin; Reference proteome; Thick filament.
FT   CHAIN           1..866
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211257"
FT   REGION          1..22
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          840..866
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          23..839
FT                   /evidence="ECO:0000255"
FT   DISULFID        750
FT                   /note="Interchain"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        423..428
FT                   /note="DQVKEL -> GSSQRI (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        430..431
FT                   /note="SS -> KL (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        637
FT                   /note="V -> L (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        639
FT                   /note="T -> I (in Ref. 2)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        691
FT                   /note="G -> E (in Ref. 2; AAA29914)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        720
FT                   /note="S -> F (in Ref. 2; AAA29914)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   866 AA;  100388 MW;  42FA5E6E78176AE0 CRC64;
     MMNHDTESHV KISRTIYRGV SPSTTRLESR VRELEDLLDL ERDARVRAER HAADLGFQVD
     ALSERLDEAG GSTTQTQELL KRREMEINKL RKDLENANAS LELAETSMRR RHQTALNELA
     LEVENLQKQK GKAEKDKSHL IMEVDNVLGQ LDGALKAKQS AESKLEGLDS QLNRLKSLTD
     DLQRQLTELN NAKSRLTSEN FELLHINQDY EAQILNYSKA KSSLESQVDD LKRSLDDEAK
     NRFNLQAQLT SLQMDYDNLQ AKYDEESEEA SNLRSQVSKF NADIAALKSK FERELMSKTE
     EFEEMKRKFT MRITELEDTA ERERLKAVSL EKLKTKLTLE IKDLQSEIES LSLENSELIR
     RAKAAESLAS DLQRRVDELT IEVNTLTSQN SQLESENLRL KSLVNDLTDK NNLLERENRQ
     MNDQVKELKS SLRDANRRLT DLEALRSQLE AERDNLASAL HDAEEALHDM DQKYQASQAA
     LNHLKSEMEQ RLRERDEELE SLRKSTTRTI EELTVTITEM EVKYKSELSR LKKRYESNIA
     DLEIQLDTAN KANANLMKEN KNLSQRVKDL ETFLDEERRL REAAENNLQI TEHKRLQLAN
     EIEEIRSTLE NLERLRKHAE TELEEAQSRV SELTIQVNTL TNDKRRLEGD IGVMQADMDD
     AINAKQASED RAIRLNNEVL RLADELRQEQ GNYKHAEALR KQLEIEIREI TVKLEEAEAS
     ATREGRRMVQ KLQARVRELE SEFDGESRRC KDALAQARKF ERQYKELQTQ AEDDRRMVLE
     LQDLLDKTQM KMKAYKRQLE EMEEVSQITM NKYRKAQQQI EEAEHRADMA ERTVTVRRVG
     PGGRAVSVAR ELSVTSNRGM RATSMM