ID   MYSP_TAESO              Reviewed;         863 AA.
AC   P35418; Q962G3;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   16-FEB-2004, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Paramyosin;
DE   AltName: Full=Antigen B;
DE            Short=AgB;
GN   Name=PMY;
OS   Taenia solium (Pork tapeworm).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX   NCBI_TaxID=6204;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=8232426; DOI=10.1016/0166-6851(93)90147-p;
RA   Landa A., Laclette J.P., Nicholson-Weller A., Shoemaker C.B.;
RT   "cDNA cloning and recombinant expression of collagen-binding and complement
RT   inhibitor activity of Taenia solium paramyosin (AgB).";
RL   Mol. Biochem. Parasitol. 60:343-347(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12632150; DOI=10.1007/s00436-002-0761-x;
RA   Vargas-Parada L., Laclette J.P.;
RT   "Gene structure of Taenia solium paramyosin.";
RL   Parasitol. Res. 89:375-378(2003).
RN   [3]
RP   PROTEIN SEQUENCE OF 239-256.
RX   PubMed=2052029; DOI=10.1016/0166-6851(91)90015-x;
RA   Laclette J.P., Landa A., Arcos L., Willms K., Davis A.E., Shoemaker C.B.;
RT   "Paramyosin is the Schistosoma mansoni (Trematoda) homologue of antigen B
RT   from Taenia solium (Cestoda).";
RL   Mol. Biochem. Parasitol. 44:287-296(1991).
CC   -!- FUNCTION: Paramyosin is a major structural component of many thick
CC       filaments isolated from invertebrate muscles. It is a prominent antigen
CC       in human cysticercosis, may have a role as a modulator of the host
CC       immune response. It is able to bind collagen and has complement
CC       inhibitor activity.
CC   -!- SUBUNIT: Homodimer or monomer in secreted form. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Secreted. Note=Thick
CC       filaments of the myofibrils. Can also be secreted.
CC   -!- SIMILARITY: Belongs to the paramyosin family. {ECO:0000305}.
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DR   EMBL; L13723; AAA16278.1; -; Unassigned_DNA.
DR   EMBL; AY034087; AAK58494.1; -; Genomic_DNA.
DR   AlphaFoldDB; P35418; -.
DR   SMR; P35418; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.5.370; -; 1.
DR   InterPro; IPR002928; Myosin_tail.
DR   InterPro; IPR014751; XRCC4-like_C.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Direct protein sequencing; Motor protein;
KW   Muscle protein; Myosin; Secreted; Thick filament.
FT   CHAIN           1..863
FT                   /note="Paramyosin"
FT                   /id="PRO_0000211259"
FT   REGION          1..18
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   REGION          837..863
FT                   /note="Nonhelical region"
FT                   /evidence="ECO:0000255"
FT   COILED          19..836
FT                   /evidence="ECO:0000255"
FT   CONFLICT        246
FT                   /note="S -> Q (in Ref. 3; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        359..360
FT                   /note="KQ -> NE (in Ref. 1; AAA16278)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        738..739
FT                   /note="EL -> DV (in Ref. 1; AAA16278)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   863 AA;  98900 MW;  571684D8CE8B8B88 CRC64;
     MSESHVKISR TIIRGTSPST VRLESRVREL EDLLDLERDA RVRAERNANE MSIQLDTMAE
     RLDELSGTSS QTHDAIRRKD MEISKLRKDL ENANAAFETA EATLRRKHNT MISEISSEVE
     NLQKQKGRAE KDKSQLMLEI DNVLGQLDGA LKAKASAESK LEGLDSQLTR LKALTDDLQR
     QMADANSAKS RLAAENFELV RVNQEYEAQV VTFSKTKAAL ESQLDDLKRA MDEDARNRLS
     LQTQLSSLQM DYDNLQARYE EEAEAAGNLR NQVAKFNADM AALKTRLERE LMAKTEEFEE
     LKRKLTVRIT ELEDMAEHER TRANNLEKTK VKLTLEIKDL QAENEALAAE NGELTHRAKQ
     AENLANELQR RIDEMTVEIN TLNSANSALE ADNMRLKGQV GDLTDRIANL DRENRQLGDQ
     LKETKSALRD ANRRLTDLEA LRSQLEAERD NLASALHDAE EALKEMEAKY VASQNALNHL
     KSEMEQRLRE KDEELENLRK STTRTIEELT TTISEMEVRF KSDMSRLKKK YEATISELEV
     QLDVANKANV NLNRENKTLA QRVQELQAAL EDERRAREAA ESNLQVSERK RIALASEVEE
     IRSQLELSDR ARKNAESELN DANGRISELT LSVNTLTNDK RRLEGDIGVM QGDLDEAVNA
     RKAAEDRADR LNAEVLRLAD ELRQEQENYK RAETLRKQLE IEIREITVKL EEAEAFATRE
     GRRMVQKLQN RVRELEAELD GEIRRAKEAF ANARKYERQF KELQTQSEDD KRMILELQDL
     LDKTQIKMKA YKRQLEEQEE VSQLTMSKYR KAQQQIEEAE HRADMAERTI TIKRTIGGPG
     SRAVSVVREI NSVSRGNRAT SIM