MYSS_RABIT
ID MYSS_RABIT Reviewed; 1084 AA.
AC P02562;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 2.
DT 25-MAY-2022, entry version 104.
DE RecName: Full=Myosin heavy chain, skeletal muscle;
DE Flags: Fragments;
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986;
RN [1]
RP PROTEIN SEQUENCE OF 1-258.
RA Capony J.-P., Elzinga M.;
RT "The amino acid sequence of A 34,000 dalton fragment from S-2 of myosin.";
RL Biophys. J. 33:148A-148A(1981).
RN [2]
RP PROTEIN SEQUENCE OF 259-428.
RX PubMed=3972832; DOI=10.1016/s0021-9258(19)83643-8;
RA Lu R.C., Wong A.;
RT "The amino acid sequence and stability predictions of the hinge region in
RT myosin subfragment 2.";
RL J. Biol. Chem. 260:3456-3461(1985).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 409-1084.
RX PubMed=3305014; DOI=10.1111/j.1432-1033.1987.tb13308.x;
RA Maeda K., Sczakiel G., Wittinghofer A.;
RT "Characterization of cDNA coding for the complete light meromyosin portion
RT of a rabbit fast skeletal muscle myosin heavy chain.";
RL Eur. J. Biochem. 167:97-102(1987).
RN [4]
RP PROTEIN SEQUENCE OF 1076-1084.
RX PubMed=2015900; DOI=10.1016/0014-5793(91)80349-8;
RA Maeda K., Rosch A., Maeda Y., Kalbitzer H.R., Wittinghofer A.;
RT "Rabbit skeletal muscle myosin. Unfolded carboxyl-terminus and its role in
RT molecular assembly.";
RL FEBS Lett. 281:23-26(1991).
CC -!- FUNCTION: Muscle contraction.
CC -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC regulatory light chain subunits (MLC-2).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC myofibrils.
CC -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles
CC of a 28-residue repeat pattern composed of 4 heptapeptides,
CC characteristic for alpha-helical coiled coils.
CC -!- DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light
CC meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further
CC cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment
CC (S2). {ECO:0000305}.
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DR EMBL; X05958; CAA29391.1; -; mRNA.
DR PIR; A02985; A02985.
DR PIR; A05280; A05280.
DR PIR; S00084; S00084.
DR AlphaFoldDB; P02562; -.
DR SMR; P02562; -.
DR IntAct; P02562; 1.
DR MINT; P02562; -.
DR PRIDE; P02562; -.
DR Proteomes; UP000001811; Unplaced.
DR GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR GO; GO:0016459; C:myosin complex; IDA:CAFA.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0051015; F:actin filament binding; IPI:CAFA.
DR GO; GO:0005524; F:ATP binding; IDA:CAFA.
DR GO; GO:0000146; F:microfilament motor activity; IDA:CAFA.
DR GO; GO:0030048; P:actin filament-based movement; IDA:CAFA.
DR Gene3D; 1.20.5.370; -; 4.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR014751; XRCC4-like_C.
DR Pfam; PF01576; Myosin_tail_1; 1.
PE 1: Evidence at protein level;
KW Actin-binding; ATP-binding; Coiled coil; Cytoplasm;
KW Direct protein sequencing; Motor protein; Muscle protein; Myosin;
KW Nucleotide-binding; Reference proteome; Thick filament.
FT CHAIN <1..1084
FT /note="Myosin heavy chain, skeletal muscle"
FT /id="PRO_0000123433"
FT REGION <1..>258
FT /note="Alpha-helical tailpiece (S2)"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION <259..1084
FT /note="Rodlike tail (S2 and LMM domains)"
FT REGION 270..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 298..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 455..1084
FT /evidence="ECO:0000255"
FT VARIANT 405
FT /note="L -> V"
FT VARIANT 408
FT /note="V -> L"
FT VARIANT 421
FT /note="E -> D"
FT VARIANT 423
FT /note="S -> G"
FT VARIANT 426
FT /note="K -> R"
FT NON_CONS 258..259
FT /evidence="ECO:0000305"
FT NON_TER 1
SQ SEQUENCE 1084 AA; 125489 MW; 229CFD69A6E1F7F0 CRC64;
SAETEKEMAN MKEEFEKTKE SLAKAEAKRK ELEEKMVALM QEKNDLQLQV QAEADSLADA
EERQDLIKTK IQLEAKIKEV TERAEDEEEI NAELTAKKRK LEDECSELKK DIDDLELTLA
KVEKEKHATE NKVKNLTEEM AGLDETIAKL TKEKKALQEA HQQTLDDLQA EEDKVNTLTK
AKTKLEQQVD DLEGSLEQEK KIRMDLERAK RKLEGDLKLA QETSMDIEND KQQLDEKLKK
LEFMTNLQSK IEDEQALMTN LQRIEELEEE IEAERASRAK AEKQRSDLSR ELEEISERLE
EAGGATSAQI EMNKKREAEF EKMRRDLEEA TLQHEATAAA LRKKHADSVA ELGEQIDNLQ
RVKQKLEKEK SELKMEIDDL AGNMETVSKA KGNLEKMCRT LEDQLSEVKT KEEEHQRLIN
ELSAQKARLH TESGEFSRQL DEKDAMVSQL SRGGQAFTQQ IEGLKRQLEE ETKAKSALAH
ALQSSRRDCD LLREQYEEEQ EAKAELQRAM SKANSEVSQW RTKCETDAIQ RTEELEEAKK
KLAQRLQDAE EHVEAVNSKC ASLEKTKQRL QNEAEDLMID VERSNATCAR MDKKQRNFDK
VLAEWKHKYE ETQAELEASQ KESRSLSTEV FKVKNAYEES LDHLETLKRE NKNLQQEISD
LTEQIAESAK HIHELEKVKK QIDQEKSELQ AALEEAEGSL EHEEGKILRI QLELNQVKSE
IDRKIAEKDE EIDQLKRNHL RVVESMQSTL DAEIRSRNDA LRIKKKMEGD LNEMEIQLNH
ANRQAAEAIK NLRNTQGILK DTQLHLDDAV RGQDDHKEQL AMVERRANLM QAEIEELRAS
LEQTERSRRV ADQDLLDASE RVQLLHTQNT SLINTKKKLE TDISQIQGEM EDIVQEARNA
EEKAKKAITD AAMMAEELKK EQDTSAHLER MKKNMEQTVK DLQQRLDEAE QLALKGGKKQ
IQKLEARVKE LENEVESEQK RNVEAVKGLR KHERRVKELT YQTEEDRKNV LRLQDLVDKL
QSKVKAYKRQ AEEAEEQSNI NLSKFRKLQH ELEEAEERAD IAESQVNKLR VKSRDVHSKV
ISEE
