ID   MYSU_RABIT              Reviewed;         501 AA.
AC   Q99105;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 86.
DE   RecName: Full=Myosin heavy chain, embryonic smooth muscle isoform;
DE   Flags: Fragment;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal aorta;
RX   PubMed=1995631; DOI=10.1016/s0021-9258(19)67861-0;
RA   Kuro-o M., Nagai R., Nakahara K., Katoh H., Tsai R.C., Tsuchimochi H.,
RA   Yazaki Y., Ohkubo A., Takaku F.;
RT   "cDNA cloning of a myosin heavy chain isoform in embryonic smooth muscle
RT   and its expression during vascular development and in arteriosclerosis.";
RL   J. Biol. Chem. 266:3768-3773(1991).
CC   -!- FUNCTION: Muscle contraction.
CC   -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy
CC       chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2
CC       regulatory light chain subunits (MLC-2).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the
CC       myofibrils.
CC   -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles
CC       of a 28-residue repeat pattern composed of 4 heptapeptides,
CC       characteristic for alpha-helical coiled coils.
CC   -!- DOMAIN: Limited proteolysis of myosin heavy chain produces 1 light
CC       meromyosin (LMM) and 1 heavy meromyosin (HMM). HMM can be further
CC       cleaved into 2 globular subfragments (S1) and 1 rod-shaped subfragment
CC       (S2). {ECO:0000305}.
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DR   EMBL; D10280; BAA01124.1; -; mRNA.
DR   PIR; A38650; A38650.
DR   AlphaFoldDB; Q99105; -.
DR   SMR; Q99105; -.
DR   STRING; 9986.ENSOCUP00000014315; -.
DR   eggNOG; KOG0160; Eukaryota.
DR   eggNOG; KOG0161; Eukaryota.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR002928; Myosin_tail.
DR   Pfam; PF01576; Myosin_tail_1; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; ATP-binding; Coiled coil; Cytoplasm; Motor protein;
KW   Muscle protein; Myosin; Nucleotide-binding; Reference proteome;
KW   Thick filament.
FT   CHAIN           <1..501
FT                   /note="Myosin heavy chain, embryonic smooth muscle isoform"
FT                   /id="PRO_0000123390"
FT   REGION          <1..501
FT                   /note="Rodlike tail (S2 and LMM domains)"
FT   REGION          182..202
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          397..501
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1..457
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        222..242
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        397..440
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   501 AA;  58119 MW;  49F793247D00973E CRC64;
     REAREKETKA LSLSRALEEA LEAKEEFERQ NKQLRADMED LMSSKDDVGK NVHELEKSKR
     ALEQQVEEMR TQLEELEDEL QATEDAKLRL EVNTQAMKAQ FERDLQARDE QSEEKKRLLT
     KQVRELEAEL EDERKQRALA VASKKKMEID LKDLEAQIEA ANKARERRVK QLRRLQAQMK
     DYQRELEEAR GSRDEIFAQS KESEKKLKSL EAEILQLQEE LASSERARRH AEQERDELAD
     EIANSASGKS ALLDEKRRLE ARMRQLEEEL EEEQSNMELL NDRFRKTTLQ VDTLNAELAA
     ERSAAQKSDN ARQQLERQNK DLKAKLQELE GAVKSKFKAT ISALEAKIGQ LEEQLEQEAK
     ERAAANKLVR RTEKKLKEIF MQVEDERRHA DQYKEQMEKA NARMKQLKRQ LEEAEEEATR
     ANASRRKLQR ELDDATEANE GLSREVSTLK NRLRRGGPIS FSSSRSGRPQ LHIEGASLEL
     SDDDTESKTS DVNETQPPQS E