ID   MYTB_MYTED              Reviewed;          34 AA.
AC   P81613;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   30-MAY-2000, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Mytilin-B;
OS   Mytilus edulis (Blue mussel).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Bivalvia;
OC   Autobranchia; Pteriomorphia; Mytilida; Mytiloidea; Mytilidae; Mytilinae;
OC   Mytilus.
OX   NCBI_TaxID=6550;
RN   [1]
RP   PROTEIN SEQUENCE, CHARACTERIZATION, AND MASS SPECTROMETRY.
RC   TISSUE=Blood;
RX   PubMed=8702979; DOI=10.1074/jbc.271.36.21808;
RA   Charlet M., Chernysh S., Philippe H., Hetru C., Hoffman J.A., Bulet P.;
RT   "Innate immunity. Isolation of several cysteine-rich antimicrobial peptides
RT   from the blood of a mollusc, Mytilus edulis.";
RL   J. Biol. Chem. 271:21808-21813(1996).
RN   [2]
RP   STRUCTURE BY NMR, DISULFIDE BONDS, AND ANTIVIRAL ACTIVITY.
RX   PubMed=17628674; DOI=10.1016/j.dci.2007.05.006;
RA   Roch P., Yang Y., Toubiana M., Aumelas A.;
RT   "NMR structure of mussel mytilin, and antiviral-antibacterial activities of
RT   derived synthetic peptides.";
RL   Dev. Comp. Immunol. 32:227-238(2008).
CC   -!- FUNCTION: Has antibacterial and antiviral activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- MASS SPECTROMETRY: Mass=3974.3; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:8702979};
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DR   PDB; 2EEM; NMR; -; A=1-34.
DR   PDBsum; 2EEM; -.
DR   AlphaFoldDB; P81613; -.
DR   BMRB; P81613; -.
DR   SMR; P81613; -.
DR   EvolutionaryTrace; P81613; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0050688; P:regulation of defense response to virus; IEA:UniProtKB-KW.
DR   InterPro; IPR019631; Myticin_preproprotein.
DR   Pfam; PF10690; Myticin-prepro; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Antibiotic; Antimicrobial; Antiviral defense;
KW   Antiviral protein; Direct protein sequencing; Disulfide bond; Immunity;
KW   Innate immunity; Secreted.
FT   PEPTIDE         1..34
FT                   /note="Mytilin-B"
FT                   /id="PRO_0000044691"
FT   DISULFID        2..27
FT                   /evidence="ECO:0000269|PubMed:17628674"
FT   DISULFID        6..29
FT                   /evidence="ECO:0000269|PubMed:17628674"
FT   DISULFID        10..31
FT                   /evidence="ECO:0000269|PubMed:17628674"
FT   DISULFID        15..34
FT                   /evidence="ECO:0000269|PubMed:17628674"
FT   HELIX           2..12
FT                   /evidence="ECO:0007829|PDB:2EEM"
FT   STRAND          16..23
FT                   /evidence="ECO:0007829|PDB:2EEM"
FT   STRAND          26..32
FT                   /evidence="ECO:0007829|PDB:2EEM"
SQ   SEQUENCE   34 AA;  3982 MW;  BC633EA90DBD294E CRC64;
     SCASRCKGHC RARRCGYYVS VLYRGRCYCK CLRC