ID   A16A1_BOVIN             Reviewed;         800 AA.
AC   A6QR56;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Aldehyde dehydrogenase family 16 member A1;
GN   Name=ALDH16A1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Ascending colon;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Interacts with SPG21. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The active site cysteine and glutamate residues are not
CC       conserved in this protein. Its activity is therefore unsure.
CC       {ECO:0000305}.
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DR   EMBL; BC150121; AAI50122.1; -; mRNA.
DR   RefSeq; NP_001095339.1; NM_001101869.1.
DR   AlphaFoldDB; A6QR56; -.
DR   SMR; A6QR56; -.
DR   STRING; 9913.ENSBTAP00000040728; -.
DR   PaxDb; A6QR56; -.
DR   PeptideAtlas; A6QR56; -.
DR   PRIDE; A6QR56; -.
DR   GeneID; 506329; -.
DR   KEGG; bta:506329; -.
DR   CTD; 126133; -.
DR   eggNOG; KOG2450; Eukaryota.
DR   InParanoid; A6QR56; -.
DR   OrthoDB; 1070579at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016620; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.309.10; -; 1.
DR   Gene3D; 3.40.605.10; -; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR016163; Ald_DH_C.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR011408; Aldehyde_DH.
DR   InterPro; IPR015590; Aldehyde_DH_dom.
DR   PANTHER; PTHR11699:SF211; PTHR11699:SF211; 2.
DR   Pfam; PF00171; Aldedh; 2.
DR   PIRSF; PIRSF036490; Aldedh_dupl; 1.
DR   SUPFAM; SSF53720; SSF53720; 2.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..800
FT                   /note="Aldehyde dehydrogenase family 16 member A1"
FT                   /id="PRO_0000312985"
SQ   SEQUENCE   800 AA;  85168 MW;  0FC45E8431D2CDA1 CRC64;
     MAATRTASRA CEIFTTLEYG PAPESHACAL AWLDTQDRHL GHYVNGQWLK PEHRSSVPCQ
     DPITGENLAS CLQAQSEDVA AAVEAARASL ENWSTQPGAI RAQHLTRLAK VIQKHQRLLW
     TLESLVTGRA VREVRDRDVP LAQQLLQYHA VQAHTQEEAL AGWEPMGVIG LILSPTFPFL
     DMMWRICPAL AVGCTVVVLV PPASPTPLLL AQLAGELGPF PGILNVISGP ASLGPVLAAQ
     PGVQKVAFCG AIEEGRALRR TLAGWVPELG LALGAESLLL LTEVADVDSA VEGIVDAAWS
     DRSPGGLRLL IQEAVWDETM RRLQERMGRL RCGHGLDGAV DMGARGAAAR DLAQRYVSEA
     QSQGAQVFQA GSEPSDSPFF PPTLVSDLPP ASPCTQAEVP WPLVVASPFR TAKEALAVAN
     GTPRGGSASV WSERLGQALE LAYGLQVGTV WINAHGLRDP AVPTGGCKES GSSWHGGQDG
     LYEYLRPSGT PAWIPYLSKT LNYDAFGLAL PSTLPAGPET GPAPPYGLFV GGRFQAPGAR
     SSRPIQDSQG SLQGYVAEGG AKDIRGAVEA AHQAAPGWMS QSPAARAALL WALAAALQRR
     EPNLVSRLER HGVELKVAKA EVELSVKRLR AWGARVQAQG CALQVAELRG PVLRLREPLG
     VLAIVCPDEW PLLAFVSLLA PALAHGNTVV LVPSGACPIP ALEVCQEMAT LLPAGLVNVV
     TGDRDHLTRC LALHQDIQAL WYFGSAQGSQ FVEWASAGNL KPVWVNRGCP RAWDQEAEGA
     GPELGRRAAR TKALWLPMGD