MZM1_PICGU
ID MZM1_PICGU Reviewed; 111 AA.
AC A5DH70;
DT 08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 51.
DE RecName: Full=Mitochondrial zinc maintenance protein 1, mitochondrial;
DE Flags: Precursor;
GN Name=MZM1; ORFNames=PGUG_02621;
OS Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX NCBI_TaxID=294746;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX PubMed=19465905; DOI=10.1038/nature08064;
RA Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA Birren B.W., Kellis M., Cuomo C.A.;
RT "Evolution of pathogenicity and sexual reproduction in eight Candida
RT genomes.";
RL Nature 459:657-662(2009).
CC -!- FUNCTION: Assembly factor required for Rieske Fe-S protein RIP1
CC incorporation into the cytochrome b-c1 (CIII) complex. Functions as a
CC chaperone, binding to this subunit within the mitochondrial matrix and
CC stabilizing it prior to its translocation and insertion into the late
CC CIII dimeric intermediate within the mitochondrial inner membrane.
CC Modulates the mitochondrial matrix zinc pool (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with RIP1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion matrix {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I LYR family. MZM1 subfamily.
CC {ECO:0000305}.
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DR EMBL; CH408157; EDK38523.2; -; Genomic_DNA.
DR RefSeq; XP_001484892.1; XM_001484842.1.
DR AlphaFoldDB; A5DH70; -.
DR SMR; A5DH70; -.
DR STRING; 4929.XP_001484892.1; -.
DR EnsemblFungi; EDK38523; EDK38523; PGUG_02621.
DR GeneID; 5126536; -.
DR KEGG; pgu:PGUG_02621; -.
DR VEuPathDB; FungiDB:PGUG_02621; -.
DR eggNOG; ENOG502S6EF; Eukaryota.
DR HOGENOM; CLU_147114_2_2_1; -.
DR InParanoid; A5DH70; -.
DR OMA; KYKLRIH; -.
DR OrthoDB; 1585902at2759; -.
DR Proteomes; UP000001997; Unassembled WGS sequence.
DR GO; GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
DR GO; GO:0034551; P:mitochondrial respiratory chain complex III assembly; IEA:InterPro.
DR CDD; cd20267; Complex1_LYR_LYRM7; 1.
DR InterPro; IPR008011; Complex1_LYR_dom.
DR InterPro; IPR045298; Complex1_LYR_LYRM7.
DR Pfam; PF05347; Complex1_LYR; 1.
PE 3: Inferred from homology;
KW Chaperone; Mitochondrion; Reference proteome; Transit peptide.
FT TRANSIT 1..13
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 14..111
FT /note="Mitochondrial zinc maintenance protein 1,
FT mitochondrial"
FT /id="PRO_0000405508"
SQ SEQUENCE 111 AA; 12422 MW; 3256041BCE9207A0 CRC64;
MSSRALSAYR AALRATRISF QQDNDVLLAA RKQIRDGFEA SRNSDNAEEE IVKMNEISKF
LVSNIVQGEK QGDGKYFLKF HDQTELGDNE TIKQNHKANM GSLAGAKAKC R