ID   MZRA_CROS8              Reviewed;         127 AA.
AC   A7MIS1;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 2.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=ESA_03507;
OS   Cronobacter sakazakii (strain ATCC BAA-894) (Enterobacter sakazakii).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Cronobacter.
OX   NCBI_TaxID=290339;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-894;
RX   PubMed=20221447; DOI=10.1371/journal.pone.0009556;
RA   Kucerova E., Clifton S.W., Xia X.Q., Long F., Porwollik S., Fulton L.,
RA   Fronick C., Minx P., Kyung K., Warren W., Fulton R., Feng D., Wollam A.,
RA   Shah N., Bhonagiri V., Nash W.E., Hallsworth-Pepin K., Wilson R.K.,
RA   McClelland M., Forsythe S.J.;
RT   "Genome sequence of Cronobacter sakazakii BAA-894 and comparative genomic
RT   hybridization analysis with other Cronobacter species.";
RL   PLoS ONE 5:E9556-E9556(2010).
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABU78722.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CP000783; ABU78722.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_004385817.1; NC_009778.1.
DR   AlphaFoldDB; A7MIS1; -.
DR   SMR; A7MIS1; -.
DR   EnsemblBacteria; ABU78722; ABU78722; ESA_03507.
DR   GeneID; 56732166; -.
DR   KEGG; esa:ESA_03507; -.
DR   HOGENOM; CLU_153761_0_0_6; -.
DR   OrthoDB; 1713717at2; -.
DR   Proteomes; UP000000260; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..127
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413183"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..127
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   127 AA;  14285 MW;  810A49CBB028A799 CRC64;
     MAFTRALSRR LTLMLSAGAL LAAMLLCWAA LQKHETTLEI RAVSQGATIP DGFSVWHHLD
     ANGIRFKSIT PQDDILLIKF DTSDQSEAAR KVLYRSLPRG FVIAQQEEKS LTPAWLTRLR
     HDIQRLG