ID   MZRA_ENT38              Reviewed;         127 AA.
AC   A4WES8;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   29-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=Ent638_3550;
OS   Enterobacter sp. (strain 638).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Enterobacter.
OX   NCBI_TaxID=399742;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=638;
RX   PubMed=20485560; DOI=10.1371/journal.pgen.1000943;
RA   Taghavi S., van der Lelie D., Hoffman A., Zhang Y.B., Walla M.D.,
RA   Vangronsveld J., Newman L., Monchy S.;
RT   "Genome sequence of the plant growth promoting endophytic bacterium
RT   Enterobacter sp. 638.";
RL   PLoS Genet. 6:E1000943-E1000943(2010).
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; CP000653; ABP62208.1; -; Genomic_DNA.
DR   RefSeq; WP_015960534.1; NC_009436.1.
DR   AlphaFoldDB; A4WES8; -.
DR   SMR; A4WES8; -.
DR   STRING; 399742.Ent638_3550; -.
DR   PRIDE; A4WES8; -.
DR   EnsemblBacteria; ABP62208; ABP62208; Ent638_3550.
DR   KEGG; ent:Ent638_3550; -.
DR   eggNOG; ENOG5032NIM; Bacteria.
DR   HOGENOM; CLU_153761_0_0_6; -.
DR   OMA; WHHLDAN; -.
DR   OrthoDB; 1713717at2; -.
DR   Proteomes; UP000000230; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..127
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413184"
FT   TOPO_DOM        1..10
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        32..127
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   127 AA;  14084 MW;  19DEC6C056C5C442 CRC64;
     MVISPLALRR LSYGLIALVL LSALILVWTA LQRQESTLAI RPVSQGASVP DGFYIWHHLD
     ANGIQFKSIT PQDDVLLIKF DSSAQSAAAK VVLDRSLPRG YIIALQDDQS QTAVWLTRLR
     DTSHRFG