ID   MZRA_ERWAC              Reviewed;         130 AA.
AC   D4I1C3;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904}; OrderedLocusNames=EAMY_3102;
OS   Erwinia amylovora (strain CFBP1430).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Erwinia.
OX   NCBI_TaxID=665029;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFBP1430;
RX   PubMed=20192826; DOI=10.1094/mpmi-23-4-0384;
RA   Smits T.H., Rezzonico F., Kamber T., Blom J., Goesmann A., Frey J.E.,
RA   Duffy B.;
RT   "Complete genome sequence of the fire blight pathogen Erwinia amylovora
RT   CFBP 1430 and comparison to other Erwinia spp.";
RL   Mol. Plant Microbe Interact. 23:384-393(2010).
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; FN434113; CBA23032.1; -; Genomic_DNA.
DR   RefSeq; WP_004160035.1; NC_013961.1.
DR   AlphaFoldDB; D4I1C3; -.
DR   SMR; D4I1C3; -.
DR   STRING; 665029.EAMY_3102; -.
DR   EnsemblBacteria; CBA23032; CBA23032; EAMY_3102.
DR   GeneID; 8914913; -.
DR   KEGG; eam:EAMY_3102; -.
DR   PATRIC; fig|665029.3.peg.2980; -.
DR   eggNOG; ENOG50333DY; Bacteria.
DR   HOGENOM; CLU_153761_1_0_6; -.
DR   OMA; WHHLDAN; -.
DR   OrthoDB; 1713717at2; -.
DR   Proteomes; UP000001841; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..130
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413185"
FT   TOPO_DOM        1..15
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        37..130
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
SQ   SEQUENCE   130 AA;  14544 MW;  A0D3700CF4585E86 CRC64;
     MTTASIKKRD PRRRLLPWLI VAFVALIGLA MIPALFRHDS TLQIRASRQG VSLPDGFYVY
     QTLSAQGIHI QSITPEQDSL VIRFDSPEQS YAAERVLRKL FAQSFDIAHQ PGPGAASWIN
     RISLLPQFVG