ID   MZRA_KLEP7              Reviewed;         128 AA.
AC   A6TED5;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Modulator protein MzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   Name=mzrA {ECO:0000255|HAMAP-Rule:MF_00904};
GN   OrderedLocusNames=KPN78578_34950; ORFNames=KPN_03524;
OS   Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=272620;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700721 / MGH 78578;
RG   The Klebsiella pneumonia Genome Sequencing Project;
RA   McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA   Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL   Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Modulates the activity of the EnvZ/OmpR two-component
CC       regulatory system, probably by directly modulating EnvZ enzymatic
CC       activity and increasing stability of phosphorylated OmpR.
CC       {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBUNIT: Interacts with EnvZ. {ECO:0000255|HAMAP-Rule:MF_00904}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00904}; Single-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
CC   -!- SIMILARITY: Belongs to the MzrA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00904}.
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DR   EMBL; CP000647; ABR78919.1; -; Genomic_DNA.
DR   PDB; 4PWU; X-ray; 2.45 A; A/B/C/D=32-128.
DR   PDBsum; 4PWU; -.
DR   AlphaFoldDB; A6TED5; -.
DR   SMR; A6TED5; -.
DR   STRING; 272620.KPN_03524; -.
DR   DNASU; 5341542; -.
DR   EnsemblBacteria; ABR78919; ABR78919; KPN_03524.
DR   KEGG; kpn:KPN_03524; -.
DR   HOGENOM; CLU_153761_0_0_6; -.
DR   OMA; WHHLDAN; -.
DR   Proteomes; UP000000265; Chromosome.
DR   GO; GO:0005887; C:integral component of plasma membrane; IEA:UniProtKB-UniRule.
DR   GO; GO:0019901; F:protein kinase binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0045859; P:regulation of protein kinase activity; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00904; Modulator_MzrA; 1.
DR   InterPro; IPR026574; Modulator_MzrA.
DR   InterPro; IPR027398; SecD-TM.
DR   Pfam; PF13721; SecD-TM1; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell inner membrane; Cell membrane; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..128
FT                   /note="Modulator protein MzrA"
FT                   /id="PRO_0000413189"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   TOPO_DOM        33..128
FT                   /note="Periplasmic"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00904"
FT   STRAND          37..45
FT                   /evidence="ECO:0007829|PDB:4PWU"
FT   HELIX           53..62
FT                   /evidence="ECO:0007829|PDB:4PWU"
FT   STRAND          68..73
FT                   /evidence="ECO:0007829|PDB:4PWU"
FT   STRAND          76..83
FT                   /evidence="ECO:0007829|PDB:4PWU"
FT   HELIX           84..97
FT                   /evidence="ECO:0007829|PDB:4PWU"
FT   STRAND          100..107
FT                   /evidence="ECO:0007829|PDB:4PWU"
SQ   SEQUENCE   128 AA;  14127 MW;  13B3FCFAD25F2EF6 CRC64;
     MMVMKRPSLR QFSWLLGGSL LLGALFWLWL AVQQQEATLA IRPVGQGIGM PDGFSVWHHL
     DANGIRFKSI TPQKDGLLIK FDSTAQGAAA KEVLGRALPH GYIIALLEDD NSPTAWLSRL
     RDAPHRLG